Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Tumour models"”.
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Towards Refinement for Measuring Subcutaneously Transplanted Tumour Models in Mice
Evaluation using mouse subcutaneous tumour models is a key process in cancer drug development. Tumour material is implanted subcutaneously and tumour growth measured using callipers. However this methodology can have poor reproducibility and accuracy due to observer variation. Furthermore the …
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Towards Refinement for Measuring Subcutaneously Transplanted Tumour Models in Mice
Evaluation using mouse subcutaneous tumour models is a key process in cancer drug development. Tumour material is implanted subcutaneously and tumour growth measured using callipers. However this methodology can have poor reproducibility and accuracy due to observer variation. Furthermore the …
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Proteomic analysis of biomarkers associated with immunotherapy in murine tumour models
… in particular vaccine therapy. The use of animal models is critical to evaluate the efficacy of immunotherapies and to investigate tumour immunity in general and the mechanisms involved in tumour progression. These models provide an in vivo environment which cannot be reproduced in vitro, which …
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Functional Investigation of Dual αvβ3 and αllbβ3 Integrin Inhibition in Haematological and Solid Tumour Models
… subunits in inducible and natural expression models (K562 and MCF-7 cells respectively), functional tests for cellular adhesion, detachment and migration were determined. Phorbol 12-myristate 13-acetate (PMA)-treated K562 cells showed increased adhesion on fibrinogen compared to untreated …
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Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
… characterised for their potential as in vivo models of primary and metastatic tumour therapy response, several showing significant potential. In addition to the development of these models, this study also addressed the pharmacokinetics of different luciferase substrates and identified optimal …
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Through barrier detection using surface enhanced spatially offset Raman spectroscopy
… the detection of ex vivo breast cancer tumour models containing SERRS active nanotags through 15 mm of porcine tissue is demonstrated. In addition, SERRS-active nanotags were tracked through porcine tissue to depths of up to 25 mm. To date, this is the largest thickness that SERRS …
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Biophysical approaches to single-cell characterization
… serous ovarian cancer vary with respect to intratumoural position. I describe an integrated method for correlating 3D radial-spatial cell positions with scRNA-seq data. By employing a basic stain-and-sort method using an off-the-shelf live-dead stain, I correlate transcriptional profiles with …
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Cancer immunotherapy with Mucin-1 and cytokines
… manipulation of the immune response to combat tumour cells. The studies contained within investigated the role of cytokines in the anti-tumour immune response to the cancer antigen, MUCl, which is over produced in an altered form in cancers of the breast, pancreas, and ovary making an ideal …
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Development of Quantitative Optical Coherence Tomography Methods for Cell Death Detection
… methods rely largely on measurements of tumour volume to assess treatment efficacy several weeks to months after the start of therapy. The development of early monitoring methods to determine a patientâ s response within the first days of a new treatment could significantly impact the …
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Organotellurium Reagents for Multiparametric Interrogation of Dynamic Biology
… mass) and administering them to human pancreatic tumour models in a temporally-spaced dosing regime, we demonstrate that tumour microenvironments experiencing temporal fluctuations in oxygenation can be highlighted reliably at the single cell level for the first time. By coupling this approach …
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Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
There is evidence from cancer patients and animal models that the immune system is able to recognise cancer cells. It is unclear whether tumours escape this immune surveillance by selection of non-immunogenic variants in a Darwinian process termed cancer immunoediting, or by the recruitment of …
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Interrogating Cancer Metabolism using Novel Imaging Techniques
… techniques, which enable the investigation of tumour metabolism in vivo and the identification of imaging biomarkers. Hyperpolarised 13C Magnetic Resonance Spectroscopic Imaging (MRSI) is a metabolic imaging technique that enables dynamic imaging of isotopically labelled metabolites in vivo, …
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Immune cell alterations in mouse models of prostate cancer
Numerous studies have demonstrated that tumour cells have the ability to alter immune function to create an immune suppressed environment. This allows tumour cells to escape immune surveillance and consequently the tumour can progress. Dendritic and T cells have critical roles in immune activation …
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Tumour ecology of breast cancer patient-derived xenografts
Tumours are complex ecosystems where several neoplastic and non-transformed cell populations (the tumour microenvironment – TME) interact in heterogeneous and dynamic ways. Descriptive studies in patient material, although extremely informative, often lack the temporal and spatial resolution needed …
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Development of imaging techniques to assess tumour cell death
… an important imaging target for assessing early tumour treatment response and the effectiveness of therapy. Traditionally, anatomical imaging modalities measure changes in tumour size (Response Evaluation Criteria in Solid Tumours (RECIST)). More recently these assessments have also included …
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The Development and Characterisation of a Peptide Delivery Platform to Interrogate the Anticancer Effects of Bisphosphonates
… PEG moiety, was employed in vivo to enhance tumour targeted specificity and to avoid clearance of RALA/ALN nanoparticles via the mononuclear phagocyte system. Lyophilised and fresh RALA/ALN and RALA++/ALN nanoparticles were evaluated in PC-3 xenograft tumour models. Fresh and lyophilised …
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… development, progression, and elimination of tumour masses. This thesis describes the assessment of a novel potential cancer treatment, Complete Freund’s Adjuvant (CFA), which is injected intratumourally in an attempt to induce an anti-tumour immune response, leading to tumour regression. CFA …
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Polyunsaturated fatty acid requirements of murine colon adenocarcinomas
… cells were not. In vivo the growth of the MAC26 tumour was stimulated by daily oral administration of LA between 0.4-2.0g/kg. There was a threshold value of 0.4g/kg for the stimulation of MAC26 tumour growth, above which there was no further increase in tumour growth, and below which no increase …
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… development, progression, and elimination of tumour masses. This thesis describes the assessment of a novel potential cancer treatment, Complete Freund’s Adjuvant (CFA), which is injected intratumourally in an attempt to induce an anti-tumour immune response, leading to tumour regression. CFA …
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Development of Optimised Pulse Sequences for Magnetic Resonance Imaging of Tumour Metabolism
… the aim of clinical translatability. Monitoring tumour cell death using 2H magnetic resonance spectroscopy and spectroscopic imaging: 2H magnetic resonance spectroscopic imaging (MRSI) has been shown recently to be a viable technique for metabolic imaging in the clinic. The relatively low …
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