Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Tumour markers"”.
-
Candidate tumour markers and potential therapeutic targets in colorectal cancer.
Aim: To identify candidate tumour-specific molecular markers for the detection of disseminated tumour cells in peripheral blood and intra-peritoneal lavage samples from patients undergoing surgical resection for CRC and as potential therapeutic targets. Results: cDNA microarray screening identified …
-
The use of novel tumour markers and statistical models in the preoperative diagnosis of ovarian cancer
Malignant ovarian tumours are diagnosed at an advanced stage in 75% of cases and they have the highest mortality figures of all gynaecological cancers. As the treatment of benign and malignant adnexal masses is significantly different it is important to be able to reliably distinguish between them …
-
Photodynamic Therapy utilizing Interstitial Light Delivery Combined with Spectroscopic Methods
… further enhanced with the use of a fluorescence tumour marker. The evolution of these tumour markers has been fuelled by the fact that many tumour markers also can be utilized for light therapy. The modality is called photodynamic therapy (PDT) and has now been clinically approved for the …
-
The dynamics of the serum concentration of CEA, CA15-3 and CA19-9 and survival in patients treated for advanced breast and colorectal cancer. The determination of the prognostic correlates of changes in tumour markers CEA, CA15-3 and CA19-9 during chemotherapy treatment for advanced breast and colorectal cancer.
There is evidence that kinetics of tumour markers (TMs) CEA, CA15-3 and CA19-9 provide valuable information about disease state over time in patients with advanced breast and colorectal cancer but the literature contains differences in methodology so comparing findings is difficult. By modifying …
-
Life Style, Molecular Pathology, and Breast Cancer Risk
… breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. A major aim of this …
-
An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… A dire need exists to identify ovarian cancer biomarkers, which could be used as good indicators of expression in ovarian cancer cells in vitro. Aim: The aim of this study was to analyse selected cancer biomarkers, which are currently under intense investigation for their suitability to diagnose …
-
Molecular and cellular expression of novel genes associated with breast cancer
… cancer care can be pursued with the use of tumour markers that are associated with risk assessment, diagnosis, prognosis, prediction of treatment outcome, monitoring of the disease and development of novel therapies. As such, this study proposed to characterise and evaluate the potential for …
-
Analysis of methylation status of CGB genes in common nontrophoblastic cancer
… hormone and its unique β-subunit are recognised tumour markers involved in enabling anti-apoptotic pathways, promotion of invasion and angiogenesis, and supporting tumour proliferation leading to more aggressive cancer and poor prognosis. The limiting factor for the hCG production is the presence …
-
Folate Metabolism in Normal and Tumour Bearing Mammals
… derivatives has been studied in normal and tumour bearing rodents. Within 48 h of administration of radioactive folate tissue radioactivity was incorporated largely into high molecular weight folate conjugates. The major derivative was isolated from rat liver and identified as …
-
Telomerase : a tumor marker in the peripheral blood of colorectal cancer patients
… suggests that the dissemination of circulating tumour cells (CTC) occurs early in the disease process. The first clinical results obtained suggest that CTC detection and enumeration can be used to estimate prognosis and may serve as an early marker to assess anti-tumour activity of a treatment. …
-
Oncogene-induced reprogramming of heterotypic cellular interactions
… are known to affect immune cells or serve as tumour markers. Comparative transcriptomic analysis with another colorectal cell line with heterozygous G12 mutations and a pancreatic cell line with inducible KRAS G12-mutant expression showed differential protein expression driven by specific KRAS …
-
Characterising DNA methylation in tissue and liquid samples from patients with renal tumours
… diagnoses, including benign and malignant tumours, the most common of which is clear cell RCC (ccRCC). Current methods are unable to confidently distinguish pathological subtypes of SRMs, meaning patients with benign tumours are undergoing unnecessary invasive surgery. In addition, there …
-
A study of the relationship of the internal endocrine environment to the p53 network, cyclin D1 and replication licensing proteins in breast cancer
Aim To assess the change in expression of various tumour markers (p53, mcm2 and cyclin D1) with change in internal endocrine environment in patients with primary breast cancer and to study the expression and prognostic association of cyclin D1 and replication licensing proteins (mcm2 and geminin) …