Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 158 for “"Tumour growth"”.
-
Role of Properdin in Tumour Growth and Cell Recruitment
… activation and<br/>has been implicated in the tumour response in human lymphoma and carcinoma.<br/>This project investigated the role of properdin in a syngeneic orthotopic tumour<br/>model in mice engineered to be properdin deficient and their wildtype controls.<br/>The in vitro part of the …
-
Decoding mechanisms of brain tumour initiating cell adaption and tumour growth
… (GBM) remains the most common malignant brain tumour with only 5% and 0.76% of patients surviving for 5 and 10 years beyond diagnosis, respectively. The cancer stem cell subpopulation of such tumours has been shown to be responsible for tumour initiation and to be able to recapitulate tumours …
-
Tumour growth model of cancer self-remission with hassell-varley functional response
… previously to model the interaction between tumour cells, hunting predator cells and resting predator cells. The aim of this study is to introduce another type of functional response which is Hassell-Varley into predator-prey interaction of tumour model of cancer self-remission. Dimensional …
-
Elucidating the role of endothelial αvβ3-integrin in tumour growth and angiogenesis
… from pre-existing ones, is essential for primary tumour growth as well as for metastasis, and endothelial cells play a central role in this process: they drive blood vessel formation in response to signals from the local environment by a mechanism that is integrin-dependent. αvβ3-integrin …
-
Toward computational oncology: nonlinear simulation of centimeter-scale tumour growth in complex, heterogeneous tissues
… sophisticated mathematical models of solid tumor growth and new numerical techniques for accurately and e?ciently solving these models. In the first model, we simulate necrotic tumor growth into perfectly-vascularized, homogeneous tissue. We solve the model using a new level set/ghost fluid method …
-
Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer
Tumour necrosis factor receptor associated factors (TRAFs) play a key role in signal transduction in mammalian cells. Several members of the TRAF family have been identified but only TRAF2 and TRAF6 are implicated in the regulation of both osteoclastic bone resorption and breast cancer. Here I …
-
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
… by frequent inactivation of the VHL tumour suppressor gene and consequent accumulation of HIF2A that drives tumourigenesis. The current clinically-approved therapies for ccRCC are those targeting the angiogenesis and mTOR signalling pathways, however, the overall patients’ objective …
-
Mathematical modelling of brain tumour growth. Integrating mechanics, phenotypic evolution, and nutrient transport to describe anisotropic behaviour and personalised therapies.
L'abstract è presente nell'allegato / the abstract is in the attachment
-
Development of the chick chorioallantoic membrane (CAM) model to assess tumour growth and drug response in osteosarcoma and bladder cancer
… in ovo model that allows visualisation of tumour growth in an in vivo-like environment while minimising animal suffering. While CAM studies have shown promise in osteosarcoma research, their application in bladder cancer (BC) remain limited. This study examines the growth patterns of two BC …
-
A cytochemical and immunological study of tumour cells
Initial tumour growth was found to be exponential following intraperitoneal inoculation of 5 x 106 Ehrlich ascites tumour cells into male BALB/c mice. After three days of this pattern the rate of growth became noticeably retarded and after 12 days a plateau phase ensued. The reduced growth rate was …
-
Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor
Background and Aim: During carcinogenesis, tumours develop multiple mechanisms to evade the immune system and suppress the anti-tumour immune response. Upregulation of Fas Ligand (FasL/CD95L) expression may represent one such mechanism. FasL is a member of the tumour necrosis factor superfamily …
-
Elucidating how αvβ3-integrin regulates neuropilin-1’s role in tumour angiogenesis in order to improve anti-angiogenic therapy
αvβ3-integrin expression is vastly upregulated in tumour vasculature, and has long been considered a key molecule in promoting tumour angiogenesis. However, its initial promise as a target in anti-angiogenic therapy has wavered since the αvβ3-integrin antagonist cilengitide did not meet its end …
-
Role of Nitric Oxide-Signalling in Hypoxia-Induced Immune Escape in Cancer
… malignant progression is the acquired ability of tumour cells to escape immune-mediated lysis. A potential mechanism by which tumour cells avoid immune destruction involves the shedding of MHC Class I Chain-Related Protein A (MICA), a Natural Killer (NK) cell-activating ligand, from the tumour …
-
Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… with adverse outcome independent of the tumour stage (p=0.046). Furthermore, this copy number gain correlated with Oncostatin M receptor (OSMR) overexpression and sensitised these cells to Oncostatin M (OSM) leading to increased Signal transducer and activator of transcription 3 (STAT3) …
-
Polyunsaturated fatty acid requirements of murine colon adenocarcinomas
… and in vivo. When serum concentrations became growth limiting in vitro, proliferation of the MAC13 and MAC26 cell lines was stimulated by linoleic acid (LA) at 18μM and arachidonic acid (AA) at 16 or 33μM respectively. This was not demonstrated by the MAC16 cell line. MAC13 and MAC26 cells were …
-
Sweat gland carcinoma of the breast: a morpho-histological study
… The Diagnosis and Treatment of Doubtful Mammary Tumours, (with M.C. Tod), 1934, The Lancet. || 6. A Histological Study of the Normal Mamma in Relation to Tumour Growth, Part I. Early Development to Maturity, 1934, Edin. Med. Journ. || 7. A HISTOLOGICAL STUDY OF THE NORMAL MAMMA IN RELATION TO …
-
The role of innate immunity in pancreatic cancer progression and treatment
Immune cells are highly abundant in the tumour microenvironment of pancreatic ductal adenocarcinoma (PDAC) and they significantly influence the entire process of PDAC tumourigenesis. While the anti-tumour response is typically mediated by adaptive immunity, cells of the innate immune system can …
-
Crosstalk between natural killer cells and cancer associated fibroblasts in the tumour microenvironment
… cytotoxic function is often impaired in the tumour microenvironment. Indeed, difficult to treat solid cancers, like pancreatic cancer, are rich in cancer associated fibroblasts (CAF) which support tumour growth and suppress immune cell functions. Overcoming barriers like CAF-derived immune …
-
The roles of the chemokines CXCL12 and CXCL16 in breast cancer.
… immunity and hence efficacious anti-tumour immune responses. The aim of this study, therefore, was to further elucidate the roles of CXCL12 and CXCL16 in breast cancer development and metastasis. To achieve this, wild-type CXCL12 and CXCL16 and antagonists of CXCL12 and CXCL16 …
-
The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells
… studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion. Stromal fibroblasts produce most of the extracellular matrix (ECM) components found in the stroma, including type I collagen. Previous in vivo …
Page 1 of 8