Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Tumour characteristics"”.
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From Education to Tumour Characteristics in Colorectal Cancer: An Analysis of the Pathways.
… and then to obesity and ultimately to tumour characteristics (stage, grade, microsatellite instability (MSI), and site) that are associated with CRC prognosis. Data came from the Ontario Familial Colon Cancer Registry. Pathways were evaluated for effect modification by sex and two …
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Life Style, Molecular Pathology, and Breast Cancer Risk
… breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. A major aim of this …
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The role of tissue inflammation in Kenyan women with breast cancer
… the cellular and signalling milieu of BC tumour microenvironment and its associations with BCrisk factors, tumour characteristics and molecular subtypes in Kenyan women with breast cancer. Methods: Molecular subtyping of 838 cases of BC was performed based on Immunohistochemistry (Figure …
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Clinical symptoms and volumetric radiological responses of acoustic neuroma patients, treated with hypo-fractionated image guided radiotherapy (IGRT) at Groote Schuur hospital between 2013 and 2016
… standard for treatment of small and medium sized tumours, although fractionated regimens are well described. Access is limited in resource-constrained settings. There are no South African data describing outcomes of AN patients treated with fractionated stereotactic radiotherapy (SRT) using …
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Long term outcomes of risk reducing salpingo-oophorectomy in the general population and in women with pathogenic variants in BRCA1 and BRCA2
… adjusted for age at breast cancer diagnosis, tumour characteristics and breast cancer treatments. Analyses were stratified by the age at BSO. Multiple imputation was used to impute missing tumour characteristics in the analyses including women with personal history of breast cancer. Key …
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Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study
… between 2013 and 2017 was conducted. Patient characteristics, tumour characteristics, disease stage, treatment, and follow-up were recorded. Primary objectives included evaluating overall and disease free survival, and analysing recurrence patterns and clinicopathological features. Results: …
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Neoadjuvant endocrine therapy for estrogen receptor positive breast cancer in an African setting
… 7 patients had an excellent response to NET with tumours that decreased in size, whereas 9 patients had tumours that increased in size despite NET. There was no statistically significant difference between the two groups in terms of patient and pre-treatment tumour characteristics, pathological …
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
… pontine glioma (DIPG) are highly aggressive tumours with no effective cures. Lack of understanding of the molecular biology of these tumours, in part due to lack of well-characterised pre-clinical models, is a great challenge in the development of novel therapies. Analysis of paired cell …
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Improving Outcomes for People Living With Unrelieved Neuropathic Cancer Pain - Understanding the Epidemiology, Patient Experience and Optimal Clinical Trial Design: The INCEPT Mixed Methods Project
… cultural and socioeconomic backgrounds and all tumour types during the last week of life, its prevalence varies. Tumour characteristics, and spiritual and social context may explain some of this variation. Future research on the experience of neuropathic cancer pain must reflect the diversity of …
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Exploring the effect of peri-operative inflammation on systemic and local breast cancer biomarkers
… cancer inflammation and influence circulating tumour DNA (ctDNA)release which may predict clinical and oncological outcomes. Aims 1. To understand the relationship between peri-operative systemic inflammation and breast tumour characteristics, surgical intervention and 30-day morbidity in …
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Deciphering The Role of miR-506 in Ovarian Cancer Drug Sensitivity
… representative molecular portraits of specific tumour characteristics and behaviours. My laboratory performed microRNA expression profiles on advanced stage EOC patients and a cluster of miRNAs, including miR-506, located on ChrXq27.3 was identified as down-regulated in EOC early relapsing …
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Integration of multi-omic data and neuroimaging characteristics in studying brain related diseases
… between neuroimaging features, including tumour characteristics and connectomics, genetics and clinical factors in brain-related diseases. In doing so, we adopted two longitudinal study designs and modelled the association between Alzheimer's disease progression and genetic factors, …
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Breast cancer incidence and survival trends by molecular subtypes in Scotland
… and mortality rates is not usually done using tumour marker data. The Scottish Cancer Registry was the first registry in the UK to collect molecular marker data and therefore, constitutes an excellent opportunity to explore incidence and survival trends over time by molecular subtypes. This PhD …
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Investigating heterogeneity and mechanisms of resistance in paediatric B-cell non-Hodgkin lymphoma
… of this type. These PDXs faithfully recapitulate tumour characteristics through passage and enable the identification of heterogeneous populations within these malignancies. One such population, known as the side population (SP), exhibits tumour initiating potential, expresses stemness-related …
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Analysis of clinical and pathological outcomes of sentinel lymph node biopsy in the SNAC Trial.
… Patients‘ weights and the mode of primary tumour presentation have a significant impact on the overall outcomes of the sentinel lymph node detection. There were variations in the outcomes of multivariate analysis of factors influencing the detection of SLNs for each technique. The False …
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Assessing the impact of non-coding mutations on breast cancer risk predisposition genes
… sequencing results to assess linked mutation/tumour phenotypes. To assess the impact of the non-coding variants on gene expression, targeted-panel RNA-Sequencing analysis in FFPE tumour samples from 96 patients with known gene regulatory region variants was performed. A publicly available …
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An investigation of the systemic inflammatory response in the peri-operative period in patients undergoing potentially curative surgery for colorectal cancer
… it is now recognised that it is not only the tumour characteristics that are responsible for cancer specific survival but also the host immune response. Part of this host response is the non-specific systemic inflammatory response. There is now a body of work examining the relationship between …
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
… occasioned by the invasive nature of malignant tumour tissue biopsy, the need for serial evaluation of tumour burden during therapy, and the need for prognostication. In a series of five studies (four clinical studies and one pre-clinical study), this research work explored the potential utility …
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The effect of deprivation and comorbidity on survival in patients with head and neck cancer
… affluent backgrounds. Survival is influenced by tumour characteristics on presentation and a range of individual factors such as socioeconomic status and comorbidity. Deprived patients of more advanced age have a higher likelihood of having comorbidity; this may be due to high-risk lifestyle …