Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Tumour Mutations"”.
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Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
… which can be altered due to specific genetic mutations. The present study evaluates the impact of specific tumour mutations on the response to carboplatin, the current standard of care, and VSV∆M51, a promising OV candidate. After a study of genetically diverse models, constitutive KRas …
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Identification of potential drug targets in glioblastoma using proteogenomic platforms
Glioblastoma Multiforme (GBM) is a solid tumour of the central nervous system. To this date, it is the most aggressive primary brain tumour in adults, and few therapeutic solutions are available. This, in addition to the aggressiveness of the tumour, determine a low survival rate in patients. The …
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Monitoring trace levels of ctDNA using integration of variant reads
… Although cancers typically have thousands of mutations in their genome, previous analyses measured only individual or up to 32 tumour-specific mutations in plasma. Here, we demonstrate that sensitivity can be greatly enhanced for any given input DNA mass by analysing a large number of …
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The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapy
… of response, though little is known on how tumours and their microenvironments are modulated by neoadjuvant chemotherapy. The thesis aims at molecularly characterising tumour changes during neoadjuvant chemotherapy in a cohort of 168 patients. Serial tumour samples at diagnosis, and, when …