Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Tumour Marker"”.
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Risk Factors of Tumour Recurrence and Reduced Survival in Rectal Cancer
… This thesis identifies potential risk factors of tumour recurrence and reduced survival – i.e., surgery-related and tumour biology-related prognostic factors – in a cohort of patients registered in the SRCR between 1995 and 1997 with 5-year follow-up. SRCR data were used and for subgroups …
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Photodynamic Therapy utilizing Interstitial Light Delivery Combined with Spectroscopic Methods
… further enhanced with the use of a fluorescence tumour marker. The evolution of these tumour markers has been fuelled by the fact that many tumour markers also can be utilized for light therapy. The modality is called photodynamic therapy (PDT) and has now been clinically approved for the …
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Functional DNA Aptamers as Biotherapeutic Molecules
… validated therapeutic targets, specifically the Tumour Necrosis Factor alpha (TNFα) and Carcinoembryonic Antigen (CEA), and block their biological functions. As well, I investigated the use of CEA and MUC1 binding aptamers as targeting agents to guide and detect the delivery of contrast …
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Telomerase : a tumor marker in the peripheral blood of colorectal cancer patients
… suggests that the dissemination of circulating tumour cells (CTC) occurs early in the disease process. The first clinical results obtained suggest that CTC detection and enumeration can be used to estimate prognosis and may serve as an early marker to assess anti-tumour activity of a treatment. …
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An investigation of insulin-like growth factor binding protein-5 (IGFBP-5) as a biomarker for the detection of early liver disease
… aim of this project was to find a suitable biomarker for the early detection of liver disease. One such biomarker that was proposed was insulin-like growth factor-binding protein-5 (IGFBP-5). IGFBP-5 is known to be involved in the wound healing response in epithelial tissues, and its expression …
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Cell surface receptor specific delivery of short interfering RNAs via bivalent aptamer-siRNA transcripts or covalent antibody-siRNA conjugates
… specifically binding to the prominent tumour marker PSMA that is overexpressed on the cell surface of prostate cancer cells was exploited for the cell surface specific delivery of Aptamer siRNAs. Previous studies have demonstrated that by the use of monovalent anti PSMA aptamer it was …
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Exploring folate conjugated liposomal delivery of thymoquinone as a novel targeted treatment for human papillomavirus associated cancers
… these drugs are required for them to reach the tumour sites which eventually may lead to the development of drug resistance and limit the effectiveness of these drugs. Therefore, there is a need to develop drug delivery vesicles to overcome such problems and carry drugs to the desired sites and …
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Breast cancer incidence and survival trends by molecular subtypes in Scotland
… with multiple subtypes defined by molecular markers, such as the oestrogen receptor (ER), that have different aetiology, targeted treatments and prognosis, yet standard reporting of incidence and mortality rates is not usually done using tumour marker data. The Scottish Cancer Registry was …