Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Tumour Infiltrating Lymphocytes"”.
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Predictive and Prognostic Value of Tumour-Infiltrating Lymphocytes in Women with Breast Cancer // Предиктивна и прогностична стойност на тумор-инфилтриращите лимфоцити при жени с рак на млечната жлеза
Ракът на гърдата (РГ) е най-честият злокачествен тумор при жените в света. По данни на Световната здравна организация (СЗО) в световен мащаб заболеваемостта от рак на гърдата е с около 2.1 млн. нови случаи, диагностицирани годишно, като в България годишно се регистрират около 4 000 нови случаи. В …
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Immune responses in primary and metastatic breast cancer
… suggests that the immune system is stimulated by tumours to manifest a response. Many breast cancers show evidence of this immune response in the form of tumour infiltrating lymphocytes. However contradictory opinions exist as to whether this response is favourable for the host or not. The …
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Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome
… cancer and endometrial cancer, but also other tumour types are linked to the syndrome. We investigated the roles of bladder cancer (study III), prostate cancer (study IV) and renal cell cancer (study V) in Lynch syndrome. Study I confirmed that the MMR index is easy to apply and identifies MMR …
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The role of tissue inflammation in Kenyan women with breast cancer
… the cellular and signalling milieu of BC tumour microenvironment and its associations with BCrisk factors, tumour characteristics and molecular subtypes in Kenyan women with breast cancer. Methods: Molecular subtyping of 838 cases of BC was performed based on Immunohistochemistry (Figure …
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Prognostic biomarker discovery from omics data using machine learning approaches
… score (indicating poor outcomes) had lower tumour infiltrating lymphocytes suggesting that these patients have immune cell deprived tumours that warrants the need for specialized treatment strategies. In my fourth chapter, I performed a meta-analysis of 10 published single-cell RNA …
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The histopathology and immunohistochemical expression of cell cycle regulators and mismatch repair gene proteins in colorectal carcinoma : a comparative study
… for this is still uncertain. It is possible that tumour morphology, location and cell cycle markers may be indicators of the underlying molecular mechanism. In a resource limited setting these factors may help to stratify which cases need further molecular testing and genetic counselling. Aims and …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
… of treatment. Recent studies investigating the tumour immune microenvironment have highlighted the prognostic significance of different tumour infiltrating lymphocyte (TIL) subsets and secreted immune factors in HGSC. However, the mechanisms promoting TIL recruitment to the tumour epithelial …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… immune responses. In particular, the tumour immune microenvironment and the interaction between immune and cancer cells are emerging as crucial factors in tumour progression, prognosis, and response to therapy in TNBC. In this study, we aimed to evaluate the relationship between these …
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Immune Infiltrates in Breast Cancer: Clinical Significance from Histopathology to Prognosis
… a central role in prognosis. Overall, increased tumour infiltrating lymphocyte (TIL) counts are associated with better outcomes. However, the prognostic significance of TILs varies by TIL type, with CD8+ (cytotoxic T-cells) generally being associated with better outcomes, and both FOXP3+ …
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Establishment of recombinant antibody technologies allowing for the generation of SNAP-tag fusion proteins
… The acute heterogenicity and complexity of TNBC tumours, together with a lack of well-defined molecular targets, complicates prognosis of the diseases resulting in patient reliance on traditional therapies, like chemotherapy, radiotherapy, and surgery, which are associated with elevated incidence …