Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Tumour Immunity"”.
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The intersection of metabolism and oxygen in T cell function and anti-tumour immunity
… oxygen in CD8+ T cell differentiation and anti-tumour immunity, with a particular emphasis on designing novel cancer immunotherapies. This thesis comprises four results chapters, the first three of which are centred around the metabolite glutarate, an oxygen sensitive metabolite with no known …
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Antioxidant PRDX1 limits CD8+ T cell effector function in the tumour microenvironment
… in detecting and orchestrating effective anti-tumour immunity. However, under this selection pressure, cancer cells progressively evolve mechanisms to undermine and subvert host immunity. Immunotherapy aimed at restoring or enhancing endogenous CD8+ T cell function has had profound clinical …
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The role of tissue-resident immune cells in PanIN to PDAC progression
… largely due to local suppression of anti-tumour immunity. Tissue-resident group 2 innate lymphoid cells (ILC2) are emerging as important immune modulators of the cancer microenvironment, although their role in PDAC remains contentious with both pro- and anti-cancer roles having been …
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Investigating the role of innate lymphoid cells in targeted radiotherapy in lung cancer
… increased production of Type 2 cytokines. In the tumour setting, ILC2s also express OX40L but do not appear to contribute to anti-tumour immunity. Probing the overall immune response to targeted lung radiotherapy in the tumour context demonstrated the importance of both the innate and adaptive …
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The role of DNA damage associated microRNAs in enhancing the chemotherapeutic responses in triple negative breast cancer (TNBC)
… is a heterogeneous aggressive type of mammary tumour which lacks a definite tailored therapeutic approach, consequently limiting treatment options to chemotherapeutic agents. Doxorubicin has demonstrated significant efficacy in the treatment of TNBC although many patients experience recurrent …
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Apoptosis and Necroptosis in Renal Cell Carcinoma // Апоптоза и некроптоза при бъбречноклетъчен карцином
… evidence in the literature that renal carcinoma tumour cells are resistant to the intrinsic and extrinsic pathways of apoptosis. Apoptosis is programmed cell death that can also occur via another, alternative pathway that is caspase-independent and involves AIF. The role of AIF in renal cell …
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Proteomic analysis of biomarkers associated with immunotherapy in murine tumour models
… efficacy of immunotherapies and to investigate tumour immunity in general and the mechanisms involved in tumour progression. These models provide an in vivo environment which cannot be reproduced in vitro, which results in more accurate and reliable information on the host response to …
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Biological effects of synthetic biomolecules that may either mimic or antagonise the function of hCG in the development of cancer and autoimmune disease
… Interestingly, hCG is also secreted by certain tumours, helping them evade immune detection by creating a tolerogenic environment. This project aimed to design and synthesize small oligopeptide aptamers that specifically bind to the Beta and Alpha-helix regions of the hCG receptor, modulating …
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A novel model system for the study of anti-tumour T-cell memory
… persisting memory T-cells can be monitored. Anti-tumour immune peritoneal exudate cells (iPEC) were produced by injecting a subtumorigenic dose of the highly metastatic, ß-gal<sup>+</sup> T-Iymphoma into the ear pinna of syngeneic DBN2 mice, followed by an intraperitoneal challenge with …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… in the Adenomatous Polyposis Coli (APC) tumour suppressor gene, and are largely refractory to current cancer immunotherapies. As presented in this thesis, examination of cancer gene expression profiles from CRC patients in large, publicly available online databases indicated that …
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Regulatory T cells and circulating cytokines : novel prognostic markers in squamous cells carcinoma of the head & neck
… and is considered a highly immunosuppressive tumour. Advances in the treatment modalities for HNSCC over the last 20 years involving surgery, radiotherapy, chemotherapy and immunotherapy are not fully reflected in increases in the 5 year survival rates, mainly due to locoregional recurrences …
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Structure guided discovery of inhibitors of indoleamine 2,3-dioxygenase (IDO1)
… that patients with high IDO1‐expressing tumours have a poor prognosis have promoted the discovery of novel inhibitors of IDO1 for development as potential anti‐cancer agents to restore tumour immunity. Work in this thesis used differential scanning fluorimetry and enzyme inhibition assays …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a highway for metastatic tumour cells, recent reports propose lymphatics as modulators of immunity, highlighting a need for greater …
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Biological, Clinical, and Functional Implications of Cell-Free DNA Topology in Cancer
… a mediator of pro-inflammatory signaling in the tumour microenvironment. Despite its mounting importance both clinically and physiologically, the biological features of cfDNA remain poorly understood. In particular, the structural relationship between cfDNA and other biological macromolecules – …
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Investigating the spatiotemporal dynamics of mononuclear phagocytes in solid tumours.
… response, including the anti-cancer response. Tumour-associated macrophages (TAM) are a universal feature of solid tumours, regardless of the cancer’s immunogenicity, but variably influence outcomes and treatment responses. DCs capture tumour antigens and upregulate CCR7, which directs their …
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Characterisation of the mechanisms of tumour-induced dysfunction of clonal T cell expansions in multiple myeloma
… improved survival, suggesting a role in anti-tumour immunity. However, these cells are dysfunctional as they do not proliferate. Thus, tumour-induced dysfunction of T cell clones may be a tumour evasion mechanism that contributes to immune escape. The primary aim of this thesis was to …
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Defining the pro-tumour impact of the evolving stromal microenvironment
Much like normal tissues, tumours require a supporting microenvironment for growth and survival, known as the tumour stroma. However, tumours represent a dynamic and turbulent environment, in which factors such as hypoxia, fibrosis, nutrient deprivation and the local cytokine milieu continually …
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Mechanisms of Evasion: Anti-Tumor Immune Suppression & TRNA-Dependent Growth in Cancer Metastasis
… cancer metastasis. During cancer progression, tumour cells employ mechanisms that suppress both adaptive and innate immune responses. While our understanding of the molecular basis of adaptive immune suppression by cancer cells has led to the development of transformative immune checkpoint …
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Modelling pancreatic cancer in vivo with patient derived organoids & humanised mouse models for the investigation of immunotherapeutic treatment response
… and immunophenotypic heterogeneity of PDAC tumours presents as a major obstacle in the assessment and development of novel therapeutic interventions. Immunotherapies aim to treat cancer through the activation and enhancement of anti-tumour immunity and have shown great success in the …
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Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
… time as they replicate and spread throughout tumours. Whilst tumour lysis helps reduce tumour burden, a secondary purpose of OVs as immunotherapies is to stimulate the host's immune system culminating in a systemic anti-tumour response. To do so relies on OVs ability to trigger to two distinct …
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