Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Tumour Immune Microenvironment"”.
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Computational profiling of the tumour immune microenvironment
A tumour comprises not only cancer cells but other populations, including immune and stroma, collectively termed the tumour microenvironment (TME). Single-cell RNA sequencing has offered unparalleled insights in different and rare cell populations. However, bulk RNA-seq remains a cost-effective and …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
… of treatment. Recent studies investigating the tumour immune microenvironment have highlighted the prognostic significance of different tumour infiltrating lymphocyte (TIL) subsets and secreted immune factors in HGSC. However, the mechanisms promoting TIL recruitment to the tumour epithelial …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… transition (EMT), and cancer-related immune responses. In particular, the tumour immune microenvironment and the interaction between immune and cancer cells are emerging as crucial factors in tumour progression, prognosis, and response to therapy in TNBC. In this study, we aimed to …
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A B-cell or a key player?: The role of the humoral immune response in melanoma, highlighting the importance of method development
Investigations of the humoral immune response to melanoma have revealed that B-cells and antibodies can play both pro and anti-tumourigenic functions. B-cells can infiltrate melanomas and become organised into a tertiary lymphoid structure; their presence have been associated with better …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… the primary cause of deaths in cancer patients. Tumour dissemination can occur through the bloodstream or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) represents the most important prognostic factor for breast cancer patients. Despite its …
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
… 80%. However, certain leukaemias and solid tumours, as well as metastatic and relapsed cancers, remain resistant to current therapeutic approaches. These patients endure aggressive therapies and severe treatment-related toxicities, often with little chance of a cure. Therefore, novel, less …
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Dissecting the genomic and epigenomic alterations underlying glioblastoma
… (GBM) is the most common intrinsic primary brain tumour, characterised by structural complexity, tumoural heterogeneity and poor prognosis. GBM tumours reactivate neurodevelopmental programmes and they are driven by GBM stem-like cells (GSCs), displaying phenotypic similarities to neural stem …