Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 161 for “"Tumour Cell"”.
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Development of imaging techniques to assess tumour cell death
Cell death is an important imaging target for assessing early tumour treatment response and the effectiveness of therapy. Traditionally, anatomical imaging modalities measure changes in tumour size (Response Evaluation Criteria in Solid Tumours (RECIST)). More recently these assessments have also …
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Targeted Imaging Agents for Detecting Tumour Cell Death following Therapy
Cell death is an important target for imaging the early response of tumours to treatment. In this study a phosphatidylserine-binding protein (C2Am) has been derivatised with a fluorine-18 containing maleimide for imaging tumour cell death in a xenograft murine advanced colorectal cancer. A one-pot, …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
… was to set up a model system for the study of tumour cell – bone cell interactions in vitro, ex vivo and in vivo and to use this system to test the efficacy of a novel therapeutic agent for the treatment of osteolytic bone disease. Co-culture or conditioned medium studies using human or mouse …
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
… In this thesis, we determined that melanoma cells had a high MCL1:BCL-XL ratio, and as a result were biased towards MCL1 due to low expression of BCL-XL. Consequently, melanoma cells were uniquely dependent on MCL1 to restrain the pro-apoptotic BH3-only proteins induced by ERK1/2 pathway …
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A study of the mechanism of action of novel inhibitors of tumour cell invasion
… the leading cause of death in cancer patients. Tumour invasion and migration are critical aspects of metastatic progression. A forward chemical genetics project was initiated in an effort to identify novel compounds that inhibit tumour invasion. After screening a natural extract library, two …
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Investigating pathways in tumour cell migration and invasion in response to novel isoquinolinone compounds
Abstract The ability of cancer cells to disseminate from a primary tumour and invade via the breaching of surrounding tissue vasculature is a hallmark of the metastatic phenotype. Cancer cells are highly dynamic adopting a wide range of mechanisms in order to accomplish this enhanced migrational …
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Molecular dissection of macrophage-tumour cell interactions to identify novel treatment strategies for pancreatic cancer
… is one of the most aggressive forms of adult tumours with a median survival time of twelve months. PDAC is highly resistant to conventional therapy which includes surgical resection of the tumour, radiation treatment and chemotherapy. PDAC cells are highly motile and invasive resulting in …
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More ins than outs for tumour cell targeting: Combining molecular imaging probes and cell-penetrating peptides
Contains fulltext : 241556.pdf (Publisher’s version ) (Open Access)
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Anticancer a-helical peptides and their structure / function relationships underpinning their interactions with tumour cell membranes
… to the discovery of toxic peptides with cancer cell specificity. Extensive research is therefore required to determine how these anticancer peptides (ACPs) function and how their structural characteristics relate to both specificity and efficacy. An ACP database comprising of 158 peptides was …
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Effect of breathing hypoxic gas mixtures followed by irradiation on tumour cell survival in experimental mouse tumors
It is generally accepted that most tumours contain radioresistant hypoxic cells, which limit the effectiveness of photon radiation. This dissertation outlines an attempt to i increase the sensitivity of mouse tumours to X- and gamma radiation by reducing the fraction of hypoxic cells in tumours. It …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
… receptor (p75NTR) is a member of the tumour necrosis factor superfamily, which relies on the recruitment of cytosolic protein partners - including the TNF receptor associated factor 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and …
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On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.
Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. Targeting of the adaptive …
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Collagen gene expression in human cancer
… and plays an important role in the processes of tumour cell invasion and metastasis during which the collagens within the stroma is degraded. Total RNA was extracted from different stages of breast cancer and adjacent normal tissue for analysis of collagen gene expression by Northern blot …
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The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration
… small pharmacological compounds to inhibit tumour cell motility, as a strategy against tumour cell migration, invasion, and metastasis. The acetylenic tricyclic bis-(cyano enone), TBE-31, has been shown to be a promising chemopreventative compound. However, its effects on cell migration are …
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Immunospecific albumin microspheres as a drug delivery system for cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma
… cytotoxic agents directly to the malignant cells. This mode of targeted delivery allows for efficient tumour cell kill whilst sparing surrounding normal tissue and substantially reducing side-effects. This project examined the possible therapeutic role of a targetable sustained drug delivery …
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Correlation between the expression of integrins and their role in cancer progression. Expression pattern of integrins αvβ3, αvβ5 and α5β1 in clinical and experimental tumour samples
The integrins play a crucial role in cancer cell proliferation, migration, differentiation, survival and angiogenesis. It has been shown that integrin expression is positively correlated to cancer dissemination, this suggests targeting selected integrins as an anti-metastatic strategy. The aim of …
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Enhancing Oncolytic Virotherapy Using Functional Genomic Screening
… of VV was to increase its ability to spread in tumours by manipulating host genes. We conducted human genome-wide RNAi screens in three tumour cell lines and identified 237 genes that upon silencing enhanced spread in two out of the three cells lines tested and 23 across all three cell lines. …
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An immunohistopathological and functional investigation of β3 integrin antagonism as a therapeutic strategy in cancer. Characterisation, development, and utilisation of preclinical cancer models to investigate novel ¿3 integrin anatgonists.
Tumour cell dissemination is a major issue with the treatment of cancer, thus new therapeutic strategies which can control this process are needed. Antagonism of integrins highly expressed in tumours is one potential strategy. The integrins are transmembrane glycoprotein adhesive receptors. Two of …
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The mechanism of HAMLET-induced cell death - cellular signalling, oncogenes and clinical perspectives
… in breast milk able to kill a wide range of tumour cells while leaving healthy, differentiated cells unaffected. The aim of this thesis was to identify mechanisms dictating HAMLET sensitivity and to define the events that lead to cell death in response to HAMLET. In Paper I we show that the …
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