Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"Tumour Biology"”.
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Novel multi-parametric, multi-modality imaging for the assessment of tumour biology in renal cell carcinoma
… are sensitive to minor variations in the tumour segmentation, which future modelling approaches should consider. Twenty-one and 47% of features were poorly reproducible after manual and algorithmic re-segmentation. Measuring response to systemic treatment becomes increasingly important …
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Development of micro fluidic based devices for studying tumour biology and evaluating treatment response in head and neck cancer biopsies
… and the clinician. Encompassing a group of tumours with distinct epidemiological and oncological behaviour, each sub site differs greatly in its management and prognosis. However, due to insufficient tissue quantities and culture techniques, research studies commonly group together different …
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Survival of breast cancer patients and the potential for better prognostication
… the survival of patients with breast cancer. Tumour biology is likely the most important; secondly, the treatment options and the response to the treatment. Individuals with the same stage and similar pathological diagnoses can experience different clinical courses. Patient factors including …
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Integrative mathematical modelling of drug responses in breast cancer PDTXs and ex vivo PDTCs
… in breast cancer, utilising patient-derived tumour xenografts (PDTXs) and ex vivo PDTX-derived tumour cells (PDTCs). A robust biobank of over 100 PDTXs, encompassing diverse breast cancer subtypes, was expanded and genomically characterised. This collection captures the broad heterogeneity of …
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The in vivo proliferation kinetics of human solid tumours
The study of tissue and tumour cell kinetics is one approach to better understanding of human tumour biology and to the formulation of better treatment strategies. Past efforts to measure in vivo the duration of cell cycle phases has been severely handicapped by the need to use radioisotopes and to …
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Risk Factors of Tumour Recurrence and Reduced Survival in Rectal Cancer
… This thesis identifies potential risk factors of tumour recurrence and reduced survival – i.e., surgery-related and tumour biology-related prognostic factors – in a cohort of patients registered in the SRCR between 1995 and 1997 with 5-year follow-up. SRCR data were used and for subgroups …
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Il cane come modello animale spontaneo di patologie neoplastiche dell'uomo: ene Ataxia-Telangiectasia Mutated (ATM) Nnella predisposizione al cancro ed importanza dei riarrangimanti genici dei geni Ig/TCR per la diagnosi e prognosi delle malattie linfoproliferative
… features, including histological appearance, tumour genetics, molecular targets, biological behaviour and response to conventional therapies. Studying dogs with cancer is likely to provide a valuable perspective that is distinct from that generated by the study of human or rodent cancers …
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Graph Representation Learning to Study the Tumour Microenvironment
… where cancer cells are embedded, known as the tumour microenvironment (TME). Recent technical advances allow the acquisition of highly multiplexed biomedical images (HMBI) that generate spatial tissue maps of dozens of proteins capturing the intricacies of the TME. Combining the …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor …
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Improved profiling and classification of the breast cancer transcriptome
… diverse disease. These differences in underlying biology require robust tumour characterisation to optimally determine likely prognosis and most appropriate treatment. High-throughput gene expression quantification has highlighted the complex molecular heterogeneity of breast cancer and has …
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Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat
… have reported that NMR cells are resistant to tumourigenesis induced by SV40 large T antigen and oncogenic RAS (SV40LT-HRASG12V), a combination of oncogenes sufficient to transform mouse and rat cells. Additionally, Tian et al. have reported that high-molecular weight hyaluronan (HMW-HA) …
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Fattori prognostici nel melanoma cutaneo e nel tumore mammario associati a caratteristiche molecolari simil-staminali
… to analyse nestin, vimentin and GR expression in tumour tissue (melanoma), and their association with clinicopathological variables, to evaluate any effect on tumour progression. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present …
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Mathematical modelling of tissue metabolism and growth
… metabolism. We consider two cases; multicellular tumour spheroids and orthopaedic tissue constructs. This thesis is divided into two parts. In the first part we will present a multispecies model of an avascular tumour that studies how a cell’s metabolism affects the cell cycle, spheroid growth and …
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Evaluating metabolism in human renal cancer using novel surgical models
… characterised the metabolic phenotypes of these tumours and for the first time, evidenced the suppression of gluconeogenesis *in vivo*. Secondly, by developing a novel *in situ* tissue sampling method, I demonstrated the profound impact of ischaemia, a variable commonly associated with …
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Genetic differences in lung adenocarcinoma cells from patients of African and European ancestry
… relevant biological distinctions in LUAD tumours between AA and EA patients stem from differential expression and mutations in genes encoding pivotal proteins such as UDP glucuronosyltransferases and cytochrome P450s, among others. Variations in the sequence and expression of these genes …
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Specific forms of TCF7L2 protein define the Wnt pathway dependent genetic program
… cancer, however their functional impact on tumour biology has not been investigated. The present work has determined that expression of the short form of TCF7L2 protein is not a product of alternative splicing; instead, the protein is predominantly expressed as the long form of the protein …
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Cis and Trans, p53 and NF-kB rules of transactivation
… (TFs) are among the most studied proteins in tumour biology, typically known to function as antagonists, although recent studies identified example of positive, even cooperative interactions. p53 and NF-kB act as dimer or dimer of dimers, bind cis regulatory elements (referred herein as …
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Investigating intratumoural heterogeneity and plasticity with multiplexed single-cell assays
… Genetic mutations alone do not fully explain tumour biology and treatment resistance given the vast genomic and phenotypic heterogeneity in tumours. There is a recent appreciation of the inherent transcriptomic heterogeneity and plastic nature of cancer cells through single-cell RNA-sequencing …
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Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer with Gene Expression and Computational Pathology
… before surgery for the removal of the tumour, which is known as neoadjuvant chemotherapy (NAT). It improves outcome for many patients, and their response to the treatment is prognostic for their overall outcome. However, not all patients who receive NAT respond to the treatment, and, as …
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Dissecting the role of cathepsin V in breast cancer
… cathepsin V may have a role in relation to ERα biology. <br/><br/>Through the development of genetic ablation models using cathepsin V shRNA in cell lines representative of different breast cancer subtypes, it was found that depletion of cathepsin V in luminal-A significantly decreased the rate …
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