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Showing 1 to 3 of 3 for “"Tumorsuppressor-Gen"”.
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Untersuchungen zu Mutation, Expression und Regulation des potenziellen Tumorsuppressor-Gens APM-1 in menschlichen Tumorzellen
Im Rahmen dieser Doktorarbeit wurden Untersuchungen zu Mutation, Expression und Regulation des Tumorsuppressor-Kandidaten APM-1 durchgeführt. APM-1 wird infolge der Integration von DNA des humanen Papillomvirus Typ 68 (HPV68) in den chromosomalen Genlocus 18q21 der Zervixkarzinom-Zelllinie ME180 …
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Development of novel RNA- and protein-based cancer therapeutics by either silencing of potential oncogenes or active restoration of a tumor suppressor gene
… that produce dominant gain of function oncogenes and loss of function tumor suppressor genes have been discovered due to their alteration in human and animal cancer cells, and by their ability to elicit cancer phenotypes in experimental models. Typical treatments for cancer include surgery, …
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Identifizierung und Charakterisierung von neuen DNA-Methylierungs-Biomarkern für das humane Mammakarzinom
… DNA methylation is essentially involved in tumorigenesis, this alteration may provide a rich source of such molecular biomarkers. In this study, six genes were analyzed for a potential utility as a DNA methylation biomarker in human breast cancer. Five of these genes (SFRP1, SFRP2, SFRP5, WIF1 und …