Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Tumor-targeted"”.
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The antitumor activity of tumor-targeted RNA replicase-based plasmid DNA
… attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it has become clear that intracellular dsRNA is more effective than extracellular dsRNA in promoting apoptosis and orchestrating adaptive immune response. To overcome the difficulty in …
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Development and Evaluation of Brain Tumor Targeted Liposome Delivery System for Paclitaxel
<p>Primary brain tumors are a relatively common cause of cancer-related deaths. High-grade gliomas are the most common type of primary brain cancer, and the affected patients have a median survival of less than 1 year. Almost all malignant gliomas are incurable with the present standards of …
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TUMOR-TARGETED RELEASE OF IMMUNOSTIMULATORY AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION OF IMIDAZOQUINOLINE-BASED PRODRUGS AND ANTIBODY CONJUGATES
… have been proposed in order to achieve the targeted delivery of anticancer agents at the tumor site. Amongst the different delivery vehicles proposed, antibody drug conjugates (ADCs) have been especially successful in the clinic. Recently, the involvement of the immune system in cancer …
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Optimization and toxocologic effects of cancer immuno-electrogene therapy using a tumor-targeted interleukin-12 gene construct
… testing of electrogene therapy (EGT) of a tumor-targeted version of interleukin-12 (IL-12) in mice. Intralesional bleomycin (BLM) and feline interleukin-12 (fIL-12) DNA injection combined with trans-lesional EP resulted in complete cure of two recurrent oral squamous cell carcinomas and an …
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LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
<p>Incomplete brain tumor removal always causes neurologic deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a …
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SYNTHESIS OF NANOCOMPOSITES BY LASER ABLATION
… in immuno-diagnostics, particularly in tumor-targeted drug delivery.
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Generation and in vivo validation of multi-functional antibody-fusion proteins for cancer therapy
… which combine antibodies against a tumor-associated antigen with the immunomodulatory properties of cytokines, represent a promising strategy to overcome these limitations. This approach aims to concentrate their biological activity at the site of disease, while limiting systemic …
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Development and Characterization of Controlled Drug Delivery Using Nanoparticles
… (<200nm) could be beneficial to realize passive tumor-targeted drug delivery through enhanced permeability and retention (EPR) effects. These drug-containing particles showed a sustained release profile. Fluorescence images indicated that these particles can be internalized by human breast cancer …
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Nanostructured gene and drug delivery systems based on molecular self-assembly
… areas of clinical interest: DNA vaccination and tumor targeted gene therapy.
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Targeted magnetic hyperthermia for lung cancer
… novel non-invasive approach for ablation of lung tumors, and is based on heat generation by magnetic materials, such as superparamagnetic iron oxide (SPIO) nanoparticles, when subjected to an alternating magnetic field. However, inadequate delivery of magnetic nanoparticles to tumor cells can …
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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers
… (NB) is the most common extracranial tumor in patients under 1 year of age and it constitutes about 8-10% of all childhood cancer. It originates from neural crest cells that normally differentiate to form the sympathetic ganglia, adrenal medulla and other paraspinal sites where …
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Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes
… of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow the conjugate to circulate longer in the body by minimizing renal and hepatic clearance, thereby …
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NANOTECHNOLOGICAL APPROACHES FOR CANCER DIAGNOSIS, TREATMENT AND MANAGEMENT: IMPLEMENTATION OF FERRITIN PROTEIN NANOPARTICLES FOR TUMOR TARGETING
… in North America and Europe reveal that tumors still represent the second cause of death. In fact, the effectiveness of many drugs is often seriously affected by lack of specificity in hitting the therapeutic target, determining the onset of toxicity issues. In this context, Nanomedicine …
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Pyrrolo[2,3-d]pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy- Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-Selectivity and Potency
… ongoing search for new cancer therapies as tumor-targeted agents (without harming normal cells or tissues) with low propensity for the development of resistance.</p> <p>Clinically used antifolates methotrexate (<strong>MTX</strong>; DHFR inhibitor), pemetrexed (<strong>PMX</strong>; TS and …
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Design, Development and Evaluation of Dual Drug Nanomedicine for Non-Small Cell Lung Cancer
… (in combination or as a single agent), lack tumor-targeted accumulation and therefore can be easily eliminated from the patient body. Moreover, some drugs are hydrophobic, and their organic solvents cause in vivo toxicity, thereby limiting their capability in clinical translation. Herein, …
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Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors
… tissues and concentration of the drug within the tumor. As such, encapsulation of chemotherapeutic agents inside nanoparticles capable of enhancing tumor-targeted drug delivery is a particularly promising innovation. Yet, initial investigations into the intratumoral fate of nanomedicines have …
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Shortwave infrared imaging and its translation to clinically-relevant designs
… imaging in blood and lymph vessels, and tumor-targeted imaging with IRDye 800CW, a dye being tested in clinical trials. Thus, we suggest that there is significant potential for SWIR imaging to be implemented alongside existing imaging modalities in the clinic.
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THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
Tumor vascularization is an important control point in cancer progression and its inhibition is a promising approach to cancer therapy. Stromal-derived factor-1 alpha (SDF-1 alpha or CXCL12) is a chemoattractant for lymphocytes, hematopoietic progenitor cells, and vascular endothelial cells. SDF-1 …
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Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies
… in the area of classical antifolates as the targeted anticancer therapies.</p><p> In this study, twelve series of classical 5-, 6- and 7-substituted pyrrolo[2, 3-d]pyrimidines were designed and synthesized. Extensive structure modifications of the pyrrolo[2, 3-d] pyrimidine scaffold were …
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Engineered Nanomaterials for Targeted Imaging and Therapy
… single molecule-based contrast agents, such as tumor-targeted delivery via the enhanced permeability and retention (EPR) effect, prolonged systemic circulation times to enhance imaging contrast efficiency, and facile surface modification for specific applications. The first part of this …
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