Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Tumor-specific antigen"”.
-
Development and characterization of immunogenic genetically engineered mouse models of pancreatic cancer
… (PDAC). In order to dissect the endogenous antigen-specific T cell response in PDAC, lentivirus encoding the Cre recombinase and a tumor specific antigen (SIINFEKL, OVA[subscript 257-264]) was delivered to Kras[superscript LSL-G12D/+]; Trp[superscript 53flox/flox] (KP) mice. We demonstrate …
-
Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment of Genital Hpv Tumors
… oncoproteins E6 and E7, which serve as ideal tumor specific antigen targets. An effective therapeutic vaccine should be able to overcome tumor mechanisms of immune-evasion and immune-suppression, while inducing a robust anti-tumor mediated response. In this dissertation I investigated a novel …
-
Bacterial outer membrane vesicles (OMVs) as a platform for personalized cancer vaccines
… is the second leading cause of death worldwide. Tumor cells contain several mutations that can generate neoepitopes, targets of an effective anti-cancer T cell response. Increasing evidence demonstrated that cancer vaccines targeting neoepitopes are effective and safe both in preclinical models …
-
SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES
… weak immune response against carbohydrate antigens has directed several novel approaches towards increasing their immunogenicity for their use as vaccine components. We hypothesized that conjugation of an L-rhamnose (Rha) moiety to a carbohydrate antigen would increase the immune response …
-
Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… (α-PD-1)) enables durable T cell-dependent anti-tumor immunity in certain cancer patients. Since a subset of patients respond to ICT, this work aims at developing a more in-depth understanding of T-cell responses to MHC class I (MHC-I) and MHC class II (MHC-II) tumor antigens that are derived …