Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Tumor-repopulating cells (TRCs)"”.
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Biomechanical regulation of epigenetics and chromatin organization in single living cells
… how mechanical forces regulate epigenetics in tumor repopulating cells (TRCs), and two, how these forces unfold chromatin and induce gene expression in single living cells. Our findings suggest that mechanical forces play critical roles in regulating nuclear structure and function. …
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Soft 3D fibrin matrices downregulate FAK expression to promote self-renewal of tumor-repopulating cells
Tumor-repopulating cells are a highly tumorigenic subpopulation of cancer cells that exhibit stem cell-like properties (e.g. self-renewal). Previous reports have shown that soft 3D fibrin matrices promote self-renewal in TRCs by promoting histone 3 lysine residue 9 (H3K9) de-methylation and Sox2 …