Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Tumor-infiltrating lymphocytes"”.
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
<p>CD8<sup>+</sup> cytotoxic T lymphocytes (CTL) frequently infiltrate tumors, yet most melanoma patients fail to undergo tumor regression. We studied the differentiation of the CD8<sup>+</sup> tumor-infiltrating lymphocytes (TIL) from 44 metastatic melanoma patients using known T-cell …
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Enhancing Adoptive Cell Therapy By Augmenting Fitness and Anti-Tumor Function of Tumor-Infiltrating Lymphocytes
… offers an <em>in vivo</em> approach to activate tumor-specific T cells, albeit in some cases, this modality does not create a sufficiently robust anti-tumor response. Thus, <em>ex vivo </em>approaches employing manipulation of immune cells, such as Adoptive Cell Therapy (ACT) using autologous …
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Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes
… the functional role of BTLA on CD8<sup>+</sup> Tumor Infiltrating Lymphocytes (TIL) from metastatic melanoma patients. Clinical trials of adoptive T-cell therapy (ACT) using autologous <em>ex vivo </em>expanded TIL have demonstrated the great potential of this immunotherapy with an overall …
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Characterization and Optimization of Antigen-Specific T Cell Responses During Ex Vivo Expansion of Melanoma Tumor-Infiltrating Lymphocytes
Treatment of metastatic melanoma with tumor reactive T cells (adoptive T cell therapy, ACT) is a promising approach associated with a high clinical response rate. However, further optimization of this treatment modality is required to increase the clinical response after this therapy. ACT in …
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Activating The 4-1Bb Pathway For The Expansion of Tumor-Infiltrating Lymphocytes For Adoptive T-Cell Therapy For Metastatic Melanoma Patients
… project focused on improving the quality of the tumor-infiltrating lymphocytes (TIL) used in Adoptive T-cell therapy by understanding the role of 4-1BB/CD137 co-stimulation during the expansion of the tumor-infiltrating lymphocytes (TIL). Adoptive T-cell therapy using TIL is a promising therapy …
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Investigation of The Functional Impact of Anti-Pd-1 On Tumor-Infiltrating Lymphocytes (Til) and Mapping of Tumor Genomic Features Relevant For Response to Til Therapy
… patients with adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TIL), but it is unknown what makes the other 57% of patients not respond to therapy. It is further unknown how particularly early doses of checkpoint inhibitors, like anti-PD-1, attribute to TIL functionality, adding …
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Quantifying T cell Mediated Killing for Melanoma Immunotherapy
… therapy (ACT), based on the adoptive transfer of tumor-infiltrating lymphocytes (TILs) has well-recognized advantages such as (1) high specificity for target cells; (2) the ability to target even micrometastases; (3) the potential to proliferate in vivo within the host thus increasing both …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… affects the immune response against primary tumors, we transplanted H31m1 sarcoma cells into wildtype and TREX1D18N/D18N mice, and compared CD8+ T cell differentiation and tumor growth. We found D18N mice had greater tumor rejection and dendritic cell maturation, and their CD8+ tumor …
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… thereby directing the cytokine payload to PD- 1⁺ tumor infiltrating lymphocytes. We aimed to determine stimulatory activity of mSOT201 for CD8+ and CD4+ T cells both in vitro and in vivo, and to assess the formation and phenotype of long-lived memory CD8+ T cells following antigen-priming and …
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Zeta-Ketten Expression bei Patienten mit SCCHN und dendritische Zellen als Stimulatoren für T-Zellen In Vitro
… activation and subsequent induction of an anti-tumor response. In patients with squamous cell carcinoma of the head and neck (SCCHN) several mechanisms of immune suppression have been described. The expression of the TCR -chain of both peripheral blood lymphocytes (PBLs) and tumor infiltrating …
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Molecular basis of immunotolerance in canine neoplasia
… soft tissue sarcomas are poorly immunogenic, as Tumor infiltrating Lymphocytes are lacking, or when present they are usually at the periphery of the tumor. Still, soft tissue sarcomas are considered immunosuppressed. Checkpoint molecules from the PD-axis are overexpressed in numerous human …
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Développement d’une méthode d’immuno-imagerie permettant d’évaluer le statut immunitaire des tumeurs
Tumor immunogenicity is an important indicator of treatment response, including radiotherapy (RT) and immunotherapy (IT). Immune checkpoint inhibitors have so far yielded only a 15% response rate in unselected patients with squamous cell carcinoma of the head and neck. Imaging the immune …
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BREAST CANCER DURING PREGNANCY AS A SPECIAL TYPE OF EARLY-ONSET BREAST CANCER: INSIGHTS INTO THE TUMOR MICROENVIRONMENT AND IMMUNE TRANSCRIPTOME
Breast cancer during pregnancy (PrBC) is a rare tumor with limited information on its immune landscape. Here, we sought to characterize the cellular composition of the tumor microenvironment (TME) and the immune transcriptome of PrBC to identify their differences from early-onset breast cancer …
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Computational dissection and prediction of cancer immunotherapy response
… considerable synergism with anti-PD1 in reducing tumor volume in murine melanoma transplantation models, and this synergism also improves anti-tumor killing by tumor infiltrating lymphocytes. Using the same cohort, we also identify 189 peaks with differential activity in both the responders and …
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OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
… analysis of murine intracranial melanoma tumors that pharmacologic inhibition of oxidative phosphorylation (OXPHOS) results in increased expression of genes consistent with activated anti-tumor immune responses. <strong>The central hypothesis of this dissertation is that OXPHOS plays a …
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Bringing Til Therapy Beyond Melanoma: Advancing The Treatment of Advanced Pancreatic and Ovarian Cancers
… to 20 years ago. However, there are many solid tumor types that are yet to receive substantial benefit from this groundbreaking therapy, two of which are pancreatic cancer (PDAC) and ovarian cancer (OvCa). As such, the 5-year survival rate for PDAC and OvCa stand at 9% and 28% respectively. …
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Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment
… limited by the tolerization of CD8⁺ T cells in tumors, rapidly abrogating anti-tumor responses. In order to better understand the factors necessary to induce, maintain and promote productive T cell responses against cancer, this research has focused on understanding and interrupting critical …
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Elucidating The Roles of Il-15 In The Tumor Microenvironment
<p>ELUCIDATING THE ROLES OF IL-15 IN THE TUMOR MICROENVIRONMENT</p> <p>Rosa M. Santana Carrero, B.S.</p> <p>Advisory Professors: Shao-Cong Sun, Ph.D. & Kimberly S. Schluns, Ph.D.</p> <p>Interleukin-15 (IL-15) is a factor that promotes activation, proliferation, cytotoxicity, and survival of CD8 T …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… serous ovarian carcinoma (HGSOC) had increased tumor infiltrating lymphocytes (TILs) compared to BRCA-wildtype (WT). To better understand the underlying immune mechanism in these tumors, a preliminary transcriptome analysis was performed on a set of microdissected HGSOC tumor specimens with …
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The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… replicating in cancer cells and inducing anti-tumor immunity. Among these viruses, the oncolytic adenovirus Delta-24-RGD has shown safety and efficacy in clinical trials for high-grade gliomas. Strategies to improve the efficacy of oncolytic virotherapy have aimed to heighten the immunogenicity …
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