Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Tumor vasculature"”.
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Targeting Nanoparticles to Tumor Vasculature
Targeting tumor vessels represents an indirect therapeutic approach in oncology by shifting the treatment away from the tumor cells themselves. Endothelial cells are generally considered genetically stable and do not use escape mechanisms against chemotherapeutic agents as frequently as tumor cells …
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Multimodality Imaging of Tumor Vasculature and Metabolism
… in America. A number of abnormal features in tumor vasculature and metabolism have been identified as imaging biomarkers to detect tumor boundary, provide physiological information, predict treatment response and guide surgeries. In chapter 2, longitudinal MRI was applied to monitor the …
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Morphological, functional, and therapeutic aspects of brain tumor vasculature: an experimental study
Contains fulltext : 145677.pdf (Publisher’s version ) (Open Access)
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Tumor vasculature and microenvironment during progression and treatment : insights from optical microscopy
In addition to cancer cells, solid tumors consist of a variety of cell types and tissues defining a complex microenvironment that influences disease progression and response to therapy. To fully characterize and probe the tumor microenvironment, new tools are needed to quantitatively assess …
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Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer
… imaging showed that the accumulation of tumor vasculature targeted long-circulating liposomes (LCL) in the tumor was significantly less than non-targeted LCL at 48 h. The accumulation of these liposomes in the peritoneal cavity was higher suggesting that they were cleared rapidly by the …
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Ionizing Radiation and Endostatin Gene Therapy Against Lung Tumor
… many advances have been made in radiotherapy, tumor radioresistance and normal tissue damage continue to always be important issues for radiation oncologists. Numerous reports have also documented that radiation exposure increases the risk for malignancy and suppresses immune mechanisms. …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
Solid tumors require blood vessels for growth, and the goal of anti-angiogenic therapy is to destroy the tumor vasculature. Recent findings suggest that anti-angiogenic therapy enhances radiation and chemotherapy responses. These findings seem paradoxical, since anti-angiogenic therapy prunes tumor …
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Unraveling The Effects of Aerobic Exercise and Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models
<p>Solid tumors are comprised of multiple cell types which communicate and work together to promote tumor progression. Advances in the treatment of solid tumors have armed clinicians with more efficacious pharmacologic agents and combinations. However, a focus on drug adjuvants in the treatment of …
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Hypoxia Activated Prodrug and Anti-Angiogenic Therapy Cooperate to Treat Pancreatic Cancer But Elicit Immune Suppressive G-Mdsc Infiltration
… prodrug TH-302 (Evofosfamide) reduces intratumoral hypoxia through a tissue remodeling process, initiates tumor vasculature reorganization, and sensitizes aggressive, spontaneous murine models of prostate cancer to immune checkpoint blockade (ICB). In a clinical trial testing the combination …
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DEVELOPMENT OF A NOVEL CLASS MULTIMODALITY NANOPARTICLE AND CYTOTOXIC CONJUGATE FOR CANCER THERAPY
… to deliver chemotherapeutics via indirect tumor targeting towards leaky tumor vasculature via Enhanced permiability and retention effect. Especially nanoparticles in combination with targetedly used therapeutic modalities such as Photo Dynamic Therapy (PDT) enhanced the efficacy of canceer …
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Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
… clinical trials of novel drugs targeting the tumor vasculature using gadolinium-DTPA (Gd) as a contrast agent. However, it has some limitations, such as reproducibility, data acquisition times, the presence of noise, extracting contrast concentration, estimating T1 relaxation and estimating …
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Shear Stress-Mediated Tumor-Endothelial Cross Talk Regulates the Angiogenic Potential of Breast Tumors In Vitro
… structural and functional abnormalities of the tumor vasculature generate regions of elevated interstitial fluid pressure and aberrant flow shear stress within the tumor microenvironment. While research has shown that the hydrodynamics of the tumor vasculature reduce transport and uptake of …
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Bevacizumab Effect on Topotecan Pharmacokinetics in a Murine Orthotopic Rhabdomyosarcoma Xenograft Model
… growth factor (VEGF) can transiently normalize tumor vasculature, thereby improving delivery of systemic chemotherapy. Bevacizumab (BEV), an anti-VEGF antibody, has been shown to transiently normalize tumor vasculature by increasing tumor vessel maturity, decreasing tumor vessel permeability, …
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Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
… tissue toxicity by improving drug specificity to tumor. Relying on the EPR effect (Enhanced Permeability and Retention), a host of nanoparticles (from micelles and dendrimers to liposomes and lipidic nanoparticles) have been developed and tested for passive accumulation into tumor interstitium. …
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Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
… agents (VDAs) that preferentially target the tumor vasculature show great promise. The naturally occurring combretastatins, especially combretastatin A-4 (CA4) and combretastatin A-1 (CA1), in suitable prodrug form, have proven to be highly effective VDAs. In this study, efforts were directed …
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Photothermal energy conversion by plasmonic nanoparticles
… of these nanoparticles, like photothermal tumor ablation, drug delivery, and microfluidic devices, depend on the conversion of light to heat. In this dissertation, we compare three nanoparticle species' theoretical absorption efficiency from electromagnetic calculations with their …
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A novel nanodelivery system for combination tumor therapy
… alone have not proven effective in inducing tumor regression in the clinic due to both the cytostatic nature of anti-angiogenic therapy and the potential formation of new regions of hypoxia within the tumor after therapy. The new therapeutic paradigm is for combining both anti-angiogenics and …
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The role of HIF-1 alpha in the localization of embryonic stem cells with respect to hypoxia within teratomas
In embryonic stem (ES) cell tumors, the hypoxia-inducible transcription factor, HIF- 1[alpha], has been shown to be a tumor suppressor, and HIF-1[alpha]-expressing cells have been shown to localize preferentially in vivo to regions near tumor vasculature. These differences were proposed to be due …
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Quantum dot-based nanomaterials for biological imaging
… QD-containing microspheres were used to image tumor vasculature in living animals, and to generate maps of size-dependent extravasation. With subcutaneously delivered nAs/ZnSe QDs, multiple lymph node mapping was demonstrated in vivo for the first time with nanocrystals. When administered …
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Mobilization of Adipose Stromal Cells In Obesity and Cancer By Sparc and Its Proteolytic Isoforms
… in obesity and is associated with promoted tumor growth. Next, by using a chimeric GFP-RFP bone marrow transplant model, we observed higher tumor infiltrating cells with ASC phenotype in obese mice compared to lean. Consistently, systemic circulating ASC frequency is six fold higher in …
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