Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Tumor suppressor proteins"”.
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Novel Roles for A-Type Lamins in Maintaining Genomic Stability
… novel regulator of 53BP1 and the retinoblastoma tumor suppressor proteins. These findings are significant, because they reveal unexpected functions of A-type lamins and novel pathways that affect genomic stability. Our findings represent an important advance in understanding how nuclear …
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Regulation mechanisms of Drosophila retinoblastoma protein stability and repression activity
The retinoblastoma (RB) family proteins are pivotal transcriptional corepressors involved in diverse cellular events. As a potent tumor suppressor, RB plays a variety of important roles including regulating cell cycle, promoting cellular differentiation, inducing cell senescence and balancing …
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Studies of the Hippo Signaling Pathway
… from Drosophila, have identified the Hpo tumor suppressor pathway as a crucial mechanism that controls tissue growth by inhibiting cell growth, proliferation and survival. Deregulation of the Hpo pathway has been implicated in various human cancers. Central to the Hpo pathway is a kinase …
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Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis
The retinoblastoma tumor suppressor (pRB) inhibits tumorigenesis by restraining cell cycle progression via repression of the E2F transcription factor family and by promoting cell differentiation via activation of lineage-specific transcription factors. In contrast, the closely related pRB …
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Basal-like breast cancer: modeling its initiation and characterizing novel EGFR variants
… patients with BBC often display mutations in the tumor suppressor p53, as well as over-expression of the epidermal growth factor receptor (EGFR) protein by immunohistochemistry, and that loss of PTEN protein is also seen occurring along with the aforementioned lesions. However, there is no model …
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The RASSF1A Tumor Suppressor Regulates a Cascade of Oncogenic Signals That Are Restrained by G1 Checkpoint Mechanisms
The RASSF1A tumor suppressor is one of the most commonly inactivated genes in cancer. To understand why epigenetic silencing of RASSF1A promotes tumorigenesis, I employed a loss of function approach to elucidate the role of RASSF1A in cancer. RASSF1A is reported to regulate apoptosis, cell cycle …
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PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN
… Tensin Homologue on chromosome Ten (PTEN) is a tumor suppressor and an antagonist of the phosphotidylinositol-3 kinase (PI3K) pathway. We identified a 576-amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base-pairs upstream of …
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Nuclear export signals (NESs) in Arabidopsis thaliana : development and experimental validation of a prediction tool
… the localization but also the activity of many proteins like transcription factors, cell cycle regulators and tumor suppressor proteins just to mention some. Also in plants the nucleo-cytoplasmic partitioning of proteins emerges as an important regulation mechanism for many plant-specific …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
… in adult kidney epithelia. Lats1/2 mutant tumors respond to immune checkpoint inhibition (ICI), as is seen in some human sRCCs. Bioinformatic analysis reveals an enrichment of serum response factor (Srf) targets amongst genes upregulated following Lats1/2 deletion. Ablating Srf in the Lats …
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Neural Mechanisms and Behaviors in Models of Conditional Nprl2 Loss
The file named "DENTEL-PRIMARY-2022-1.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
… factor that is up-regulated in human tumors and after exposure to cell stress. Understanding the regulation of sCLU expression in cancer, and after exposure to therapeutic agents, could reveal new therapeutic targets for cancer treatment. A DNA damage induced signaling cascade leading …