Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 405 for “"Tumor suppressor"”.
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Tumor suppressor pathway in myocardium
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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p14ARF : A p53-Independent Tumor Suppressor
… p16 and p14, that play a pivotal role in tumor surveillance.</p> <p>Breakdowns in the p14 pathway have been estimated to be present in approximately 40% of human cancers and only recently have its binding partners and effects begun to be defined. Its interaction with the p53 pathway, which …
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Role of the ARF Tumor Suppressor in Osteoclasts
The ARF tumor suppressor is upregulated upon oncogenic stress. ARF can suppress cell proliferation in both p53-dependent and -independent mechanisms. We have focused on ARF's ability to suppress protein synthesis in a p53-independent manner. Given that protein synthesis and the cell cycle are …
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Prolyl Isomerase Pin1 Is a Conditional Tumor Suppressor
… Pin1 substrates involved in cell cycle and tumorigenesis. During cell cycle progression, the timely synthesis and degradation of key regulatory proteins is required to maintain genomic integrity. Previously, we determined that Pin1 binds to and promotes the degradation of the oncoprotein …
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The Role of LKBI Tumor Suppressor in Endometrial Cancer
… this role was not anticipated based on the tumor spectrum observed in Peutz Jegher women, many tumor suppressors have been found to have a much broader role in cancer than would have been predicted on the tumor spectrum associated with the hereditary syndrome. The studies that comprise this …
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… including binding to proto-oncogenes and tumor suppressors to regulate cell death. Here we show that the IP3R binds to the tumor suppressor BRCA1. BRCA1 binds directly to the IP3R and causes destabilization of the IP3R closed state resulting in an increased open probability and increased …
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Negative regulation of gene expression by the tumor suppressor p53
The tumor suppressor p53 inhibits the expression of a substantial number of genes whose protein products serve to promote cell survival or cell cycle progression, thereby ensuring efficient execution of p53-dependent apoptosis, cell-cycle arrest or senescence. Furthermore, p53-mediated repression …
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Regulation of the Arf tumor suppressor by E2F transcription factors
Effective tumor suppression requires the appropriate function of two major signaling pathways, the pRB-E2F growth-control pathway and the p53 stress-response pathway. Members of the E2F family of transcription factors are key downstream targets of the retinoblastoma protein, pRB, and mediate the …
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Functional analysis of the Neurofibromatosis Type II tumor suppressor gene
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. Using …
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PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN
… Tensin Homologue on chromosome Ten (PTEN) is a tumor suppressor and an antagonist of the phosphotidylinositol-3 kinase (PI3K) pathway. We identified a 576-amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base-pairs upstream of …
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Analysis of the function of the Nf2 tumor suppressor protein, Merlin
The Neurofibromatosis type 2 tumor suppressor gene (NF2) is mutated in inherited and sporadically occurring central nervous system tumors. The NF2 encoded protein, merlin, shares close sequence similarity in its amino-terminal domain to members of the band 4.1 family of membrane-cytoskeletal …
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Mutagenesis of the p̳53 tumor suppressor gene studied in Saccharomyces cerevisiae
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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TGF-beta Activated Kinase-1 (TAK1) Is a Critical Prostate Tumor Suppressor
… associated with high grade prostate tumor. We hypothesize that TAK1 is a critical prostate tumor suppressor. In vitro, we knocked down TAK1 in an established mouse prostatic progenitor/stem cell (PrP/SC) line (WFU3) and knocked out TAK1 in TAK1<super>lox/lox</super> mouse prostatic …
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blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
… to transform normal cells into cancerous tumors. Additional driver mutations or epigenetic alterations are required to cooperate with the activating Ras mutations in tumorigenesis. In C. elegans, worms homozygous for activated Ras mutations have 60 - 80% penetrant visible multivulval (Muv) …
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Regulation of the Tumor Suppressor ARF by TGFβ in Human Cancer Cells
… its role as a "dual-edged sword," acting as a tumor suppressor or oncogene depending on the context. Though preliminary work has looked at the basic connections between TGFβ pathway components and their necessity for induction of ARF, many open questions remain, especially in translating …
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Aberrations of A Putative Tumor Suppressor Gene Sel1L In Pancreatic Ductal Adenocarcinoma
… </em>(<em>SEL1L</em>) is a putative tumor suppressor gene that is downregulated in a significant proportion of human pancreatic ductal adenocarcinoma (PDAC). It was hypothesized that <em>SEL1L</em> expression could be down-modulated by somatic mutation, loss of heterozygosity (LOH), …
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MiR-145 is a tumor suppressor in both tumor progression and metastasis
… and colon cancer; moreover, it functions as a tumor suppressor capable of inhibiting tumor cell growth both in vitro and in vivo. In this study, we show that a putative tumor suppressor, miR-145, is regulated through the phosphoinositide-3 kinase (PI-3K)/Akt and p53 pathways. Importantly, p53 …
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Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer
… and high heterogeneity of this disease. The tumor heterogeneity is a result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of mammary epithelial cells are …
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Defining the functions of a conserved hydrophobic domain in the ARF tumor suppressor
The INK4A-ARF locus encodes two tumor suppressors; p16 and p19Arf, both of which restrain cell growth by regulating the functions of Retinoblastoma (Rb) and p53 respectively. Throughout development, p19Arf is kept at minimal levels, but under conditions of oncogenic stress, p19Arf expression is …
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