Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Tumor responses"”.
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Regulation of Protective B cell Anti-Tumor Responses
The role of B cells in tumor progression is complex and often overlooked. Specifically, little is known about the extent to which the specialized populations of innate-like B-1a and B-1b cells participate in and contribute to the anti-tumor immune response. The totality of work presented in this …
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<i>In Vivo</i> Murine Melanoma Tumor Responses to Nanosecond Pulsed Electric Field Treatment
… electric fields (nsPEF) were applied to melanoma tumors to observe functional and structural biological changes and to investigate the possible molecular mechanisms responsible. An animal model was set up by injecting B16F10 mouse melanoma cells into SKH-1 mice. A treatment (Tx) of 100 pulses: 300 …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… cellular therapies. Rather than acting solely on tumors, metabolic dysfunction dismantles antitumor immunity both locally and distally. Distally, chronic systemic inflammation and stromal remodeling distort the architectural integrity of secondary lymphoid organs. This systemic decay disrupts …
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Elucidating The Roles of Il-15 In The Tumor Microenvironment
<p>ELUCIDATING THE ROLES OF IL-15 IN THE TUMOR MICROENVIRONMENT</p> <p>Rosa M. Santana Carrero, B.S.</p> <p>Advisory Professors: Shao-Cong Sun, Ph.D. & Kimberly S. Schluns, Ph.D.</p> <p>Interleukin-15 (IL-15) is a factor that promotes activation, proliferation, cytotoxicity, and survival of CD8 T …
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Targeting Pd-1/Pdl-1 Signaling In The Treatment of Osteosarcoma Lung Metastasis
… of NK cells and/or macrophages in the anti-PD-1 responses. We demonstrated that PDL-1 is expressed in human OS cell lines and in lung metastases from OS patients, implying that its importance as a potential therapeutic target in OS. Further, <em>in vivo</em> anti-murine-PD-1 administration led to …
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Regulation of macrophage activities by tumor growth: mechanisms of immunosuppression
… (Mφ) are a major immune cell involved in anti-tumor responses. Mφ activities such as tumor cytotoxicity. presentation of tumor-associated antigens, and stimulation of anti-tumor lymphocytes are all involved in the battle against tumor growth. However, other Mφ activities such as cell growth …
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Transcription factor modulation in T-cells to improve cancer immunotherapy
… CAR-T capacity to proliferate and mediate anti-tumor responses in vivo, but signals induced by antigen stimulation and IL-2 supplementation during tumor-specific T-cell culture couple proliferation to differentiation, creating an inverse relationship between ex vivo expansion and anti-tumor …
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Efficacy and Mechanism of Â-Defensin2 Fused Antigen Protein Vaccines
… in order to elicit stronger anti-antigen immune responses are referred to as murine â-defensin2 (mBD2) vaccines. Previous studies have validated the potential of mBD2 vaccines, thus in this study we focus on increasing vaccine efficacy as well as mechanism elucidation. Initially, we demonstrate …
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Ube4B Levels Determine The Efficacy of Egfr and Stat5 Inhibitors In Treatment Resistant Neuroblastoma
… growth factor receptor (EGFR) in neuroblastoma tumors can result in enhanced EGFR signaling, uncontrolled proliferation, and may provide a mechanism for chemotherapy resistance. UBE4B, an E3/E4 ubiquitin ligase, ubiquitinates the EGFR and promotes its lysosomal degradation ultimately attenuating …
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Logic-gated activity sensors for programmable detection of antitumor immunity
… and imaging probes that selectively highlight tumor margins based on the expression of multiple enzymes to improve surgical resection. These examples highlight the potential of computational nanomaterials that, despite being cell- and gene-free, can apply logic as a means to increase detection …
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LINOLEIC ACID UNLEASHES THE ANTI-TUMOR POTENTIAL OF CD8 T CELLS BY PROMOTING METABOLIC REPROGRAMMING
… in the treatment of cancer, but scarce intra-tumor infiltration, persistence and function of adoptively transferred T cells limit its efficacy, especially in solid tumors. Metabolic constraints imposed by the tumor microenvironment (TME) greatly influence the success of immune-based therapies. …
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
… their capacity to elicit protective immune responses, alone or in combination, using cancer mouse models. Furthermore, we tested whether cancer cell-derived exosomes (TEXs) and OMVs can form complexes and whether such complexes, which carry TEX- associated tumor antigens and OMV-associated …
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Phase I Clinical Trial of Recombinant Oncolytic Newcastle Disease Virus for Intracranial Meningioma
… one of the most commonly diagnosed intracranial tumors in dogs and humans. Treatment failures resulting in local recurrence and death remain common in tumors of high grade, prompting a need for additional therapeutic options that are both effective and affordable. Genetic modification of the …
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A materials-based approach for localized delivery of cancer immunotherapy
… therapy may be critical to maximizing anti-tumor responses in the clinic. Inflammatory cytokines such as interleukins-2, 12 and 15 promote potent anti-tumor immunity, but systemically administered cytokines are also highly toxic. In this thesis, we engineered cytokines with a peptide tag …
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Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… (α-PD-1)) enables durable T cell-dependent anti-tumor immunity in certain cancer patients. Since a subset of patients respond to ICT, this work aims at developing a more in-depth understanding of T-cell responses to MHC class I (MHC-I) and MHC class II (MHC-II) tumor antigens that are derived …
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
… has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a subset of patients with advanced melanoma, yet current response rates are low for reasons that …
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First-order statistical speckle models improve robustness and reproducibility of contrast-enhanced ultrasound perfusion estimates
… the quantification and monitoring of adaptive tumor responses in the face of anti-angiogenic treatment, with the goal of informing targeted therapy. However, conventional CEUS image analysis relies on mean signal intensity as an estimate of tracer concentration in indicator-dilution modeling. …
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Cd56-Specific T Cells: Using Genetically Engineered T Cells to Redirect Specificity to A T Cell Expressed Antigen
… have redirected specificity to CD56<sup>+</sup> tumor cells and generate anti-tumor responses in neuroblastoma xenograft studies in mice. These CD56CAR<sup>+</sup> T cells expand similarly to CAR<sup>+</sup> T cells that do not target self-antigen, CD19-specific CAR<sup>+ </sup>T cells, and do …
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Delineating The Immunometabolism Of Human Invariant Natural Killer T Cells
… for activation. iNKT cells exert robust anti-tumor cytotoxicity through both direct mechanisms and by modulation of other immune populations. However, the use of these cells for immunotherapies has been quite limited, remaining in early clinical stages. This is largely due to our limited …
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Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment
… limited by the tolerization of CD8⁺ T cells in tumors, rapidly abrogating anti-tumor responses. In order to better understand the factors necessary to induce, maintain and promote productive T cell responses against cancer, this research has focused on understanding and interrupting critical …
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