Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Tumor resection"”.
-
Παράγοντες αποτυχίας ενδοπροθετικής αποκατάστασης με ογκολογικές μεγαπροθέσεις μετά από εκτομή όγκων μυοσκελετικού συστήματος / Risk factors for failure of endoprosthetic reconstruction with megaprostheses after musculoskeletal tumor resection
Η διάσωση άκρων με τη χρήση μεγαπροθέσεων έχει βελτιωθεί σημαντικά στη σύγχρονη ορθοπαιδική ογκολογία, ωστόσο η μακροχρόνια επιβίωση των ασθενών και των εμφυτευμάτων, καθώς και ο κίνδυνος επιπλοκών, παραμένουν σημαντικά ζητήματα. Η παρούσα προοπτική μελέτη παρελθόντος, περιελάμβανε 340 διαδοχικούς …
-
Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery
… remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during surgery, often leading to incomplete tumor …
-
A histological and immunological response study of an implantable microcapsule drug delivery device for the treatment of glioblastoma
… (GBM) and the more prevalent metastatic brain tumor are some of the most deadly forms of cancer, accounting for the death of nearly 14,000 individuals yearly. Previous treatment options for brain cancers include tumor resection, radiation, and chemo therapy but such options provide limited …
-
LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
<p>Incomplete brain tumor removal always causes neurologic deficit, disease recurrence and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a …
-
Analysis of Cancer Margins in Mass Spectrometry Images
… analysis of metabolite activity surrounding a tumor border could enhance intraoperative tumor resection. One method to collect this data is mass spectrometry imaging, an analytical technique that can detect the patterns of metabolites within a sample and retain the spatial information. The …
-
CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
… multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent antitumor …
-
Finite Element Modeling Driven by Health Care and Aerospace Applications
… thereby avoiding damage to eloquent areas during tumor resection. This thesis presents a deformable registration framework that utilizes multi-tissue mesh adaptation to map preoperative MRI to intraoperative MRI of patients who have undergone a brain tumor resection. Our enhancements with mesh …
-
Quantitative immunhistochemische Bestimmung der Mikroangiogenese unter Berücksichtigung der Proliferationsmarker Ki67, EGFR und des Tumorsuppressorgens p53 in Plattenepithelkarzinomen der Mundhöhle und des Oropharynx
… use of the angiogenic factors cd34 and cd105. As tumor progression being a multistep process we furthermore took the proliferation markers ki67 and egfr and the tumor suppressor gene p53 into account being markers playing a key role in tumor progression. Included in the retrospective analysis were …
-
Real-time Image Processing on an FPGA for an Intraoperative Goggle Device
… green (ICG) has been widely used for assessing tumor margins during intraoperative procedures. Typically, the dye is intravenously injected into the patient, and after 24 hours the dye is removed from the patient’s body, except where binding between the dye and tumor cells has occurred. This …
-
Optical Imaging Of Tissue Physiology With Exogenous Contrast Agents
… could be useful for image guidance during tumor resection surgery, and could also provide rapid and useful constraining information for more comprehensive fluorescent tomography.
-
Application of a Periosteum-bone Allograft for Healing of Segmental Bone Defects
… bone defects annually caused by trauma or bone tumor resection worldwide.[1] However, about 15-40% of these cases result in unsuccessful healing because of a persistent gap or nonunion between the graft and the original bone.[2] Under such circumstances, the Landis Laboratory is now trying to …
-
Optimization and toxocologic effects of cancer immuno-electrogene therapy using a tumor-targeted interleukin-12 gene construct
… testing of electrogene therapy (EGT) of a tumor-targeted version of interleukin-12 (IL-12) in mice. Intralesional bleomycin (BLM) and feline interleukin-12 (fIL-12) DNA injection combined with trans-lesional EP resulted in complete cure of two recurrent oral squamous cell carcinomas and an …
-
Efficacy of novel immunotherapeutic strategies targeting L1CAM in pancreatic cancer
… mostly at advanced stages, excluding primary tumor resection as putative curative treatment, early metastasis and profound therapy resistance. A promising target for new therapeutic options is the L1 cell adhesion molecule (L1CAM) which is upregulated in PDAC cells in most PDAC tissues and …
-
Multiphoton Endoscopy
… to provide real-time margin assessment during tumor resection as well as guide or replace conventional biopsy procedures. A challenge faced in the realization of a clinically useful MPE is achieving multiple imaging parameters (e.g., high resolution, fast frame rates, large field of view (FOV), …
-
Effects of Transcranial Direct-Current Stimulation on Motor Learning in the Developing Brain
… laparoscopic surgical skills, and neurosurgical tumor resection skills may be sensitive to enhancement as well. In summary, our findings suggest that tDCS application is safe in the developing brain, and capable of producing robust behavioral changes. These findings support the translation of …
-
Developing & applying a miniaturized active microchip device
… the most common and aggressive malignant brain tumor. Treatment of GBM is a daunting task with median survival just at 21 months. Methods of localized delivery have achieved moderate success in treating GBM. Depot devices have been limited due to the relatively narrow drug distribution profile …
-
USE OF NEAR-INFRARED FLUORESCENCE WITH INDOCYANINE GREEN IN SMALL ANIMAL SURGICAL ONCOLOGY AND IN CADAVERIC ANATOMICAL STUDY
… and removal 2. the application of real-time tumor fluorescence-guided surgery (TFGS) for intraoperative decision-making regarding surgical margins 3. the use of NIRF-ICG lymphography in cadavers to support anatomical studies. In the first research line, NIRF-ICG demonstrated comparable …
-
The use of optical coherence tomography to enhance surgical margin assessment for canine mast cell tumors
… majority of surgical instrumentation used for tumor excision created a high-scattering region with local architectural disruption. Blood pooling was visible as a high- scattering layer overlying tissue with normal architecture. Only the scalpel blade created a focal, low-scattering area …
-
Transorbital Endoscopic Surgery for Sphenoid Wing Meningioma: Long-term Outcomes & Surgical Technique
Sphenoid wing meningiomas are benign tumors that result in proptosis, visual impairment and pain. Traditional open surgical approaches are associated with significant morbidity. Transorbital endoscopic surgery has been developed as a minimally invasive approach to gain access to these tumors and …
Page 1 of 2