Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Tumor physiology"”.
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Development of high-speed two-photon microscopy for biological and medical applications
… important applications in neuronal imaging, tumor physiology study, and optical biopsy. A practical limitation of TPM is its slow imaging speed (0.3 1 frames/s). We designed high-speed two-photon microscopes (HSTPMs) whose imaging speed is more than 10 times faster than traditional TPM, while …
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Biologically Inspired Design of Protein-Silica Hybrid Nanoparticles for Drug Delivery Applications
… on exploiting the inherent differences in tumor physiology and limiting the exposure of drugs to non-tumorous tissue, which is commonly achieved by encapsulation of chemotherapeutics within macromolecular or supramolecular carriers that incorporate targeting ligands and that enable …
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Quantitative measurement and modeling of the DNA damage signaling network : DNA double-strand breaks
… of chemotherapy-induced cytotoxicity in tumors. Cells that experience DNA damage can initiate a DNA damage-mediated cell-cycle arrest, attempt to repair the damage and, if successful, resume the cell-cycle (arrest/repair/resume). Cells can also initiate an active cell-death program known …
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Development of Low Frequency Electron Paramagnetic Resonance Methods and Instrumentation for Biological Applications
… biophysical tool that can be used to measure tumor physiology. With the addition of magnetic field gradients, the spectral properties of paramagnetic species can be mapped. To facilitate EPR imaging, methods and instrumentation at frequencies between 250 MHz and 1 GHz were developed.</p> <p>At …
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Understanding Radiation Resistance in Head and Neck Tumor Xenografts Using Diffuse Reflectance and Raman Spectroscopy
… are limited to anatomical measurements of tumor burden using CT scan or MRI 4-8 weeks after completion of treatment. However, earlier knowledge of radiation-response prior to or at early days after commencement of therapy can aid oncologist with escalating and de-escalating treatment plans …
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Therapeutic Aerobic Exercise in a Mouse Model of Breast Cancer: Effects on Tumor Progression, Angiogenesis, and Response to Chemotherapy
… mechanisms by which physical activity affects tumor physiology are poorly understood. Accordingly, clinicians lack critical information to properly advise breast cancer patients on the use of exercise as an adjunct to more conventional therapies.</p><p>The beneficial effects of exercise on …
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Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
<p>There is a critical need to target tumor hypoxia as patients with hypoxic tumors have worse prognosis due to aggressive phenotypes and resistance to radiotherapy and chemotherapy. The overall goal of this work is to improve response to conventional cancer therapies by targeting tumor hypoxia. …
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A new prompt gamma spectroscopy-based approach for range verification in proton therapy
… translates into a high dose conformality in the tumor, as well as into a superior sparing of normal tissue compared to conventional radiotherapy with photons. Today, there are 107 proton therapy and 14 carbon ion centers operating worldwide, and many new ones are under construction. In Italy, the …
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Ultrasound and photoacoustic methods for anatomic and functional imaging in image guided radiation therapy
… goal is to noninvasively measure SaO2 in breast tumors in mice using photoacoustic computed tomographic (PCT) imaging and compare those measurements to a gold standard for pO2 using the OxyLite probe. First, a calibration study was performed to measure the SaO2 (co-oximeter) and pO2 (Oxylite …