Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Tumor necrosis factor-α (TNF-α)"”.
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Fumarate Inhibits TNF-α Release
… acid (LTA). And respond by releasing tumor necrosis factor-α (TNF-α). While beneficial for neutralizing acute pathogen exposure, prolonged TNF-α release results in chronic inflammation and tissue damage. In the present study, we examined two methylated derivatives of a citric acid …
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Tumor Necrosis Factor-α Production By Murine Peritoneal Macrophages in Response to Candida Albicans Yeasts, Germ Tubes, and Mycelia
… the production of a variety of cytokines, one is Tumor Necrosis Factor-α. TNF-α has been implicated as a mediator in endotoxic shock syndrome. However, there is also evidence that this cytokine can have beneficial effects when produced at low levels. The focus of this study was to determine if …
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Regulation of macrophage activities by tumor growth: mechanisms of immunosuppression
… (Mφ) are a major immune cell involved in anti-tumor responses. Mφ activities such as tumor cytotoxicity. presentation of tumor-associated antigens, and stimulation of anti-tumor lymphocytes are all involved in the battle against tumor growth. However, other Mφ activities such as cell growth …
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Variable Tnf-α Production By Murine Macrophages to a Cell Wall Extract of Candida Albicans
… the production of the inflammatory cytokine, tumor necrosis factor α (TNF-α). Since mannan is a component of the fungal cell wall that has been indentified as an important virulence factor in the pathogenicity of C. albicans, we examined its ability to stimulate macrophages to produce TNF-α. …
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Physical training, inflammation and bone integrity in elite female rowers
… year lead to changes in mineral properties and factors that regulate bone (sclerostin (SOST), osteoprotegerin (OPG)), and receptor activator of nuclear factor kappa-B ligand (RANKL)) and energy metabolism (insulin-like growth factor-1 (IGF-1) and leptin), and inflammation (tumor necrosis …
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Suppressive Effects of Transforming Factor-β and Interleukin-10 on the Cytolytic Activity of Murine Macrophages and Reversal by Cytokines
… the suppressive effects of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) on peritoneal macrophage killing of H238 target cells and the potential for reversal of the immunosuppressive effect by IL-4 and interferon-γ (IFN-γ) were investigated. The responsiveness of naive and …
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Anti-Inflammatory Effect of Berry Essences
… (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), which accelerate the development of other chronic diseases. Accordingly, targeting these pro-inflammatory factors is one of the important roles for anti-inflammatory agents. For last two decades, researches about …
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Insights into the mechanisms of wound repair and the role of TP508 in tissue regeneration
… agents lipopolysaccharide (LPS) and tumor necrosis factor-α (TNF-α). Using electric impedance measurements, it was shown that knockdown of PTP-PEST in HPAEC conferred resistance to barrier disruption, suggesting LPS and TNF-α may activate PTP-PEST. However, subsequent experiments …
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Gender Differences In Cardiomyocyte Remodeling and Adhesion In Response to Chronic Elevations In Myocardial Stress
<p>Estrogen has been documented to attenuate tumor necrosis factor α (TNF-α) mediated proinflammatory effects on the cardiovascular system. The first half of this study sought to determine whether gender difference exists in cardiomyocyte remodeling during chronic volume overload (CVO) induced by …
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The Regulation Of Myeloid Inflammatory Responses By Runx1: Roles In Normal And Malignant Hematopoiesis
… of pro-inflammatory mediators, including tumor necrosis factor α (TNF-α), by bone marrow neutrophils in response to TLR1/2 and TLR4 agonists. Hematopoietic RUNX1 loss also resulted in profound damage to the lung following inhalation of the TLR4 ligand lipopolysaccharide. However, …
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Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
<p>Previous studies have shown that tumor necrosis factor-α (TNF-α) can augment the antitumor effects of radiation, inhibiting tumor progression to a greater extent than either modality alone. However, nonspecific toxicities associated with TNF-α have limited its use as an adjuvant. This limitation …
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A Preclinical Model of Ionizing Radiation and TNF-alpha Gene Therapy for Cancer
<p>Long term control of high-grade brain tumors is rarely achieved with current therapeutic regimens. This study sought to determine if pretreatment with plasmid DNA expressing Tumor Necrosis Factor-α (TNF-α) could enhance the effect of ionizing radiation in an aggressive, rapidly growing glioma …
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Targeting brain inflammation with bioconjugated nanoparticles
… chain reaction (RT-PCR). Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), E-selectin, and intercellular adhesion molecule-1 (ICAM-1) displayed significant overexpression when compared to the control. …
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Monocyte Derived Dendritic Cells: Sentinels and Translators of Immune Response to Staphylococcus aureus
… of granulocyte-macrophage colony stimulating factor (GMCSF) and tumor necrosis factor-α (TNF-α) gene transcription. We continued our studies to identify the role of TNF-α in the LSA induced differentiation of monocyte to MonoDC. Blocking TNF-α reduced the expression of CD11c and increased the …
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Fibrosarcoma-induced Dysregulation of Interleukin (IL)-1β and IL-18 Activities and their Modulation by Paclitaxel
… to the suppression of normal immunologic antitumor responses. Normal host (NH) macrophage (Mϕ) populations have tumoricidal effects such as tumor antigen phagocytosis and presentation, and cytokine production. Tumor-infiltrating Mϕs may evade these activities by dysregulating production of …
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Επίδραση της επιμήκους γαστρεκτομής με ή χωρίς εκτομή του επιπλόου στην ευαισθησία στην ινσουλίνη, στην έκκριση των ορμονών του γαστρεντερικού και στα επίπεδα των λιποκυτταροκινών σε ασθενείς με σοβαρού βαθμού παχυσαρκία
… Αντιπονεκτίνη, Ομεντίνη, Ιντερλευκίνη-6 (IL-6), tumor necrosis factor-α ((TNF-α), C-αντιδρώσα πρωτεΐνη υψηλής ευαισθησίας (hs-CRP), high-density lipoprotein (HDL) χοληστερόλη, γλυκόζη νηστείας, ινσουλίνη και αντίσταση στην ινσουλίνη (εκτιμωμένη με εφαρμογή -‐ 106 -‐ Quickie Test) μετρήθηκαν και …
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The Effect of Walnuts Compared to Fatty Fish on Plasma and Erythrocyte Fatty Acid Composition, Lymphocyte Subsets and Inflammatory Mediators
… observed in blood interleukin-1 β (IL-1β), IL-6, tumor necrosis factor- α (TNF-α) and C-reactive protein (CRP) among the three diets; nevertheless the walnut diet-related values were lower. The fish diet intake decreased the concentration of soluble intracellular adhesion molecules (sICAM-1) …
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The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant
… to determine the mRNA and protein expression of tumor necrosis factor-α (TNF-α), a potent pro-inflammatory mediator, following exposure to CRN in mouse and human macrophages and human T cells. These studies demonstrated a significant reduction in TNF-α mRNA and protein in CRN-treated cells …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… evidence suggests that the pro-inflammatory Tumor Necrosis Factor-α (TNF-α) and anti-viral interferon- β (IFN-β) cytokines are highly expressed in MCV lesions and surrounding tissue. Despite the expression of pro-inflammatory factors, MCV infections cause little inflammation. Not …
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Effects of mannan oligosaccharide on immune function and disease resistance in pigs
… stimulated AMφ from MOS-fed pigs produced less tumor necrosis factor-α (TNF-α) (P < 0.01) and more IL-10 (P = 0.051) than AMφ from the control-fed pigs. Dietary MOS did not affect AMφ-produced cytokines induced by polyinosinic:polycytidylic acid (Poly I:C). When applied in vitro, MOS suppressed …
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