Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Tumor immune surveillance"”.
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
<p>The binding of immune inhibitory receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a …
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The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation
… a notable target, primarily activates the innate immune system, inducing strong antitumor responses. Direct cGAMP delivery into tumors has demonstrated significant antitumor effects in vivo. Despite this, knowledge gaps persist regarding immune cell types in the tumor microenvironment and their …
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Investigation of T cell-mediated immune surveillance against tumor-specific antigens in genetically engineered mouse models of cancer
The association of tumor cells and lymphocytes has led to the hypothesis that our immune system actively inhibits the formation and progression of cancer, a phenomenon called tumor immune surveillance. T cells specific to mutant proteins have been identified in cancer patients and the recent …
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The role of NK cells in selectin-dependent tumor suppression
… of adhesion molecules that are critical for immune cell trafficking. In our laboratory, mice lacking all combinations of selectins have been generated. Previous work from our laboratory has demonstrated that, in the absence of selectins, human tumors transplanted subcutaneously into Rag2'- …
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INKT CELLS CONTRIBUTE TO COLORECTAL CANCER PROGRESSION INDUCING NEUTROPHILS PRO-TUMORIGENIC FUNCTIONS
… with opposite roles in CRC. Hyperactivation of immune cells can lead to chronic colitis and colitis-associated CRC, equally hyporesponsive immunity can promote disease progression, while anti-tumorigenic immunity efficiently limits tumor growth. Mucosal immunity is involved in the patrolling of …
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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer
… the natural defense against viral infections and tumor immune surveillance. Through complex interactions between NK cell receptors and target cell ligands, transformed or unhealthy cells are identified and rapidly eliminated. NK cells have been used for therapeutic purposes in pediatric oncology, …
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Novel Regulators of Cellular Secretion Alter The Tumor Microenvironment to Drive Metastasis
… Golgi exocytosis to the invasive front of the tumors to promote metastasis. Altered Golgi functions promote secretion of extracellular components like MMPs, collagens, glycosaminoglycans, cytokines, etc., thus priming the tumor microenvironment for malignancy. However, the drivers that …
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Membrane Bound Il21 Promotes Natural Killer Cell Expansion Through Mir 124-3P Mediated Regulation
… Killer (NK) cells are cells of the innate immune system that act as first line of defense against viral infections and participate in tumor immune surveillance. NK cells do not cause graft versus host disease (GvHD), or require prior antigen exposure to exert anti-tumor activity, hence are …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
<p>Metastatic relapse may arise from disseminated tumor cells (DTCs) that undergo a period of dormancy before reactivating and progressing to life-threatening disease. How cancer cells evade ensuing immune surveillance upon reactivation is poorly understood, but critical for the development of …