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Showing 1 to 17 of 17 for “"Tumor cell migration"”.
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Effects of interstitial flow on tumor cell migration
… transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial cells, and mesenchymal stem cells. However, due to limitations in experimental procedures and …
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Mechanotransduction of interstitial fluid stresses and effects on tumor cell migration
… related deaths are due to metastases, secondary tumors at a site distant from the primary tumor. Metastasis formation requires carcinoma cells to navigate through the tumor microenvironment and invade the surrounding stroma. Migration is a highly orchestrated process in which cells are guided by …
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Green Tea Polyphenol Epigallocatechin-3-gallate Inhibits Hepatocyte Growth Factor-Induced Tumor Cell Migration and Invasion In Vitro and In Vivo
" 간세포성장인자(hepatocyte growth factor,HGF)와 그 수용체인 Met의 과 활성화는 많은 종류의 종양의 발생과 진행에 관여하는 것으로 알려져 있다. 본 연구에서는 HGF/Met 신호전달체계를 효과적으로 억제하는 물질을 찾아보고자하였고 녹차의 성분 중 생체에 영향을 주는 중요한 polyphenol인 Epigallocathechin-3-gallate(EGCG)가 HGF/Met 신호체계를 효과적으로 억제할 수 있다는 것을 발견하였다. EGCG는 HGF에 의한 Met의 활성 방식이 autocrine이든 …
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Lattice-gas cellular automata for the analysis of cancer invasion
Cancer cells display characteristic traits acquired in a step-wise manner during carcinogenesis. Some of these traits are autonomous growth, induction of angiogenesis, invasion and metastasis. In this thesis, the focus is on one of the latest stages of tumor progression, tumor invasion. Tumor …
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The Cx3Cl1-Cx3Cr1 Chemokine Axis Contributes to Tumor Immune Evasion and Its Blockade Enhances Responses to Anti-Pd-1 Immunotherapy
<p>CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. While CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration, the mechanisms employed by this axis …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
… in endocytic functions. However, in epithelial tumors like colorectal adenocarcinoma (COAD), aberrant splicing leads to the expression of the myosin VIshort isoform, promoting tumor-cell migration. Using the Caco-2 cell line, capable of modulating isoform expression under different conditions, …
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Invasionshemmung von Magentumorzellen nach Behandlung mit Phospholipiden in vitro
Tumors of the peritoneal cavity, such as castric cancer can cause a peritoneal carcinomatosis. Patients have a median survival of six month from time of diagnosis. The peritoneal carcinomatosis leaves no curative therapeutic option. Therefore the prevention of the PC should be the main goal. There …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… ACIDIC DOMAIN AND EGF-LIKE MODULE IN GLIOMA MIGRATION, INVASION, AND SIGNALING</p> <p>HEATHER M. MCCLUNG</p> <p>Advisor: Sandra A. Rempel, Ph.D.</p> <p>Major: Pharmacology</p> <p>Degree: Doctor of Philosophy</p> <p>We have previously shown that Secreted Protein Acidic and Rich in Cysteine …
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Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… in vitro by culturing mammary epithelial cells as 3D spheroids embedded in a reconstituted basement membrane. I first used this assay to characterize the role of cell-cell and cell-ECM adhesion in the formation and polarization of the apical junction complexes in normal mammary epithelial …
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Microfluidic Dual-Gel Cell Culture Model For Studying Cell Migration Under Controlled Interstitial Flow
… occurring in the interstitial space of the extracellular matrix (ECM), affects the migration of many cell types through individual and synergistic contributions of several biophysical and biochemical phenomena. Notably, interstitial flow is linked to ECM permeability and provides direct …
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Synthetic Peptide Ligand Mimetics and Tumor Cell Motility
Human tumor cell progression and metastasis is partially dependent on the ability of tumor cells to adhere to the proteins of the extracellular matrix and migrate to distant locations. Using a combinatorial screening approach, six novel D-amino acid containing peptides were identified and analyzed …
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The Role of Receptor Tyrosine Kinase Axl In Pancreatic Ductal Adenocarcinoma and Its Regulation By Hematopoietic Progenitor Kinase 1
… Axl silencing by shRNA in pancreatic cancer cell lines, panc-28 and Panc-1, decreased tumor cell migration and invasion and sensitized PDA cells to apoptosis stimuli such as γ-irradiation and serum starvation. In addition, we found that Axl-mediated Akt and NF-κB activation and up regulation …
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Engineered microvasculature platforms to study tumor-host-matrix interactions during metastatic seeding
… is enabled by hematogenous dissemination of tumor cells via the circulation. In particular, tumor cell extravasation is thought to be an essential and potential rate-limiting step, as most metastases are found in the extravascular space rather than intraluminal at distant organs. However, …
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In vitro study of cancer cell extravasation in microfluidic platform
Cancer metastases arise from the cancer cells that disseminate from the primary tumor, intravasate into the vascular system and eventually transmigrate across the endothelium into to a secondary site through a process of extravasation. Microfluidic systems have a major advantage in studying cancer …
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Humoral immune response to melanoma: discovery and evaluation of anti-melanoma antibodies
… nature. While numerous studies have examined T cell-mediated immune responses to melanoma and their therapeutic potential, there has been less focus on B cell-mediated immune responses and the tumor-reactive antibodies they produce. The aim of this work was three-fold: (1) to develop a …
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Determinanten der Tumorzellmigration
… erhöhten Konzentrationen in der Umgebung solider Tumore auf. Es ist bekannt, daß HS die Zellmigration vieler Zellarten stimuliert. Im ersten Teil dieser Arbeit wurde die Rolle der HS in der Tumorzellmigration auf der Basis eines dreidimensionalen Fibringel-Systems, in welches Tumorzell-bedeckte …
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Modulation of T Lymphocytes by Tumor-Released Survivin
<p>The tumor microenvironment is an area of intense interaction between normal and malignant cells. Factors and cell types within this environment can play a crucial role in the progression or regression of the tumor. Of primary interest are tumor-infiltrating T lymphocytes, which have been shown …