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Showing 1 to 20 of 373 for “"Tumor cell"”.
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Cooperative Invasion Between Tumor Cell Subpopulations
… are not attributable to the primary breast tumor, but to metastases in vital organs. Tumor cell invasion is an early step in the metastatic cascade which can occur collectively by multiple cells cooperatively invading into the surrounding stroma. Primary patient breast tumors and …
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
<p>In response to oxidative injury murine tumors depend upon the GSH oxidation-reduction cycle. The susceptibility of tumor cells to lysis by a flux of H<sub>2</sub>O<sub>2</sub>, such as generated by granulocytes or activated macrophages, or by the enzyme glucose oxidase, was augmented by …
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Studies on Ehrlich Ascites Tumor Cell Membranes
Made available in DSpace on 2014-12-10T22:38:16Z (GMT). No. of bitstreams: 1 7121097.pdf: 5532283 bytes, checksum: 5905d2c809d596373ddf2873ba4876c8 (MD5) Previous issue date: 1971
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Tumor cell deformability in the metastatic cascade
During the process of metastasis, tumor cells must undergo changes that enable them to detach from a tumor, exit surrounding tissue during intravasation, enter into circulation and eventually stop at a distant site for extravasation. Here, we measure the physical changes in the deformability of …
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Synthetic Peptide Ligand Mimetics and Tumor Cell Motility
Human tumor cell progression and metastasis is partially dependent on the ability of tumor cells to adhere to the proteins of the extracellular matrix and migrate to distant locations. Using a combinatorial screening approach, six novel D-amino acid containing peptides were identified and analyzed …
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Effects of interstitial flow on tumor cell migration
… transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial cells, and mesenchymal stem cells. However, due to limitations in experimental procedures and …
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Apoptotic cells promote circulating tumor cell survival and metastasis
During tumor progression and especially following cytotoxic therapy, cell death of both tumor and stromal cells is widespread. Despite clinical observations that high levels of apoptotic cells correlate with poorer patient outcomes, the physiological effects of dying cells on tumor progression …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… shape, regulate enzyme activity, and underscore cellular metabolism. When redox poise fails and cells are overcome by oxidation, cellular death soon follows. Redox biology is an especially important aspect of cancer cell biology, because oncogene-induced hyperproliferation results in pro-oxidant …
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Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC
Nearly 40,000 new cases of head and neck squamous cell carcinoma (HNSCC) are annually diagnosed in the United States. The current standard of care for HNSCC patients consists of chemoradiation often combined with targeted therapeutic agents. However, the five-year survival rate for patients that …
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Tumor cell extravasation in an in vitro microvascular network platform
A deeper understanding of the mechanisms of tumor cell extravasation is essential in creating therapies that target this crucial step in cancer metastasis. Extravasation assays exist, but with limitations; data from in vivo models are frequently inferred from low-resolution end-point assays while …
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Tumor cell-immune cell interaction: A lethal two way street
… role of Fas ligand in the development of anti-tumor immunity. The LSA tumor specific cytotoxic T lymphocyte (CTL) clone, PE-9, expressed both Fas and Fas ligand. This CTL clone upregulated Fas and Fas ligand expression upon activation through the T-cell receptor and induced apoptosis in Fas+, …
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Cellular Plasticity And Heterogeneity: Implications In Tumor Cell Invasion And Metastasis
The existence of heterogenous subpopulations of cells in cancer has been shown to arise via natural evolution or through movement between cellular states collectively known as “cellular plasticity.” This heterogeneity and plasticity are critical drivers of phenotypic diversity culminating in many …
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Molecular Mechanisms of Circulating Tumor Cell Adhesion in Breast Cancer Metastasis
During hematogenous metastasis, tumor cells dissociate from a primary tumor, migrate through the tissue space, and enter the circulatory system. The circulating tumor cells (CTCs), once bloodborne, travel to distant sites, where they adhere to the endothelial cells lining the vessel wall, …
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Mechanotransduction of interstitial fluid stresses and effects on tumor cell migration
… related deaths are due to metastases, secondary tumors at a site distant from the primary tumor. Metastasis formation requires carcinoma cells to navigate through the tumor microenvironment and invade the surrounding stroma. Migration is a highly orchestrated process in which cells are guided by …
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Role of protein kinase C isoforms in human breast tumor cell survival
… 12 unique isoforms that function in a variety of cellular processes including proliferation, apoptosis, differentiation and carcinogenesis. The contribution of individual PKC isoforms to these processes is largely unexplored. The purpose of this study is to identify specific PKC isoforms that …
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Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion
<p>Head and neck squamous cell carcinoma (HNSCC) is a common malignant disease with poor prognosis. The majority of patients die from local invasion or lymphatic metastasis. The mechanism(s) underlining the invasiveness of HNSCC are poorly understood. Utilizing a panel of HNSCC cell lines …
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition
… to kinase inhibitors prescribed on the basis of tumor genotype, and nearly all responsive patients eventually develop resistance, limiting the curative potential of these agents. A more complete understanding of the molecular basis underlying therapy failure is required for designing new agents …
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Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
… and women. Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) which represent 80-85% and 15-20% of cases, respectively. My dissertation project focused on understanding how to model the interactions between lung cancer cells, fibroblasts and immune …
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Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
… transition (EMT) of cancer cells is a key feature of the metastatic cascade and is not a binary process but often generates malignant cells with both epithelial (E) and mesenchymal (M) traits known as hybrid EM cells. Recent studies highlight the enhanced metastatic potential …
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Tumor-Cell Derived Inhibin, Beta A Is Essential For Adrenergic Effects On Fibroblast Activation
… adrenergic signaling are known to increase tumor growth and metastasis by direct effects on tumor cells. However, knowledge of effects of adrenergic signaling on other cells such as cancer-associated fibroblasts (CAFs) within the tumor microenvironment is limited. We hypothesize that …
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