Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Tumor biology"”.
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Adaptive Intensity Modulated Radiation Therapy Planning Optimization with Changing Tumor Geometry and Biology Enforcing Both Cumulative and Fraction Size Dose Constraints
… the goal of maximizing dose delivered to the tumor while sparing healthy tissues from excessive radiation and keeping dose homogeneous across the tumor. Although IMRT plans are optimized as a single overall treatment plan, they are delivered over 30-50 treatment sessions (fractions) and both …
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Studies of Replication Repair Deficient Brain Tumorigenesis Using Mouse Modeling
… adolescents, and young adults. RRD brain tumors are characterized by universal hypermutation, resistance to standard chemoradiation, and variable susceptibility to immune-based therapies. Despite their clinical relevance, representative immunocompetent models of recently defined RRD …
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Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
… complexity of the native three-dimensional (3D) tumor microenvironment, resulting in a lack of correspondence between preclinical data and clinical trial outcomes. The establishment of high-throughput 3D models able to describe distinctive aspects of the tumor niche would advance our …
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Telomeric Regulation of Chromosomal Instability In Colorectal Cancer
… genomic events, its role in shaping tumor biology during carcinogenesis is not well understood. Here, we explored the molecular and biological impact of telomere dysfunction and associated CIN <em>in vivo</em> in a faithful model of CRC. <em>In vivo </em>lineage tracing revealed that …
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Age-associated alterations in head and neck cancer
… that alter the function of tissues, including tumors, such as cellular senescence, reduced immune functions, and altered stromal composition. Despite these tissue modifying features and the largely elderly HNSCC patient population, most pre-clinical cancer models are comprised exclusively of …
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Compressive stress enhances coordinated migration of mammary carcinoma cells
… on genetic and biochemical changes during tumor progression. Uncontrolled cell proliferation of a solid tumor in a confined space not only creates well-studied oxidative stress (hypoxia), but also generates growth-induced mechanical stress (compression). However, the importance of such …
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Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis
… expression of oncogenic K-ras to drive tumorigenesis. The conditional allele is controlled by the Cre-loxP system. Using adenovirus to deliver Cre recombinase to the lungs we have controlled the timing and multiplicity of tumor initiation. We used this model to investigate several …
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The Adar-Mavs Pathway Is A Critical Mediator of The Innate Immune System In Pancreatic Development and Cancer
… role of Adar in pancreatic development and tumor biology. Through genetic mouse models, we conclusively show that the primary function of Adar in the pancreas is to prevent aberrant activation of the Mavs-mediated innate immune pathway, thereby maintaining pancreatic homeostasis. Pancreatic …
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Quantitative analysis of the EGFRvIII mutant receptor signaling networks in Glioblastoma
… (GBM) is the most aggressive adult brain tumor and remains incurable despite multimodal intensive treatment regimens. EGFRvIII is a truncated extracellular mutant of the EGF receptor (EGFR) that is commonly found in GBMs and confers tumorigenic behavior. Although much work has been done …
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
<p>Wilms tumor is one of the most common solid tumors in children. It is an embryonic cancer of the kidney and is thought to arise from undifferentiated renal mesenchyme. However, the differentiation status of cells in the mesenchyme that can give rise to Wilms tumors is unknown. Gene expression …
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Computational analysis of cell-cell communication in the tumor microenvironment
… stromal cells influences many aspects of in vivo tumor biology, including tumorigenesis, tumor progression, and therapeutic resistance. As a result, targeting receptor-ligand interactions, for instance with immune check-point inhibitors, can provide significant benefit for patients. However, our …
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The Biological and Immunological Effects of Irreversible Electroporation and Combination Therapy Options for the Improving the Treatment of Pancreatic Cancer
… This is due to the inaccessibility of the tumor by surgical and thermal ablative means, high potential for chemoresistance and metastasis, and strongly immunosuppressive tumor microenvironment that makes new treatment measures ineffective in clinic. Irreversible electroporation (IRE) …
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NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… cancer types, where they are crucial for tumor biology. Concomitantly, tumor cells also have enhanced expression of antioxidant pathway proteins to detoxify excess ROS. Thus, a challenge for anti-cancer therapeutics is to fine-tune this delicate balance from ROS protection, to ROS …
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Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development
… this environment and they are known to modulate tumor development. One of these GAGs, dermatan/chondroitin sulfate (CS/DS), is attached to proteins either bound to the cell surface or secreted in the extracellular space. CS/DS is a long linear polysaccharide consisting of alternating disaccharide …
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Metabolomic Biomarkers for Colorectal Cancer
… yielding unique and invaluable information about tumor biology, has been employed. Using a range of spectroscopy and mass spectrometry techniques, we have sought to characterize the changes in the serum metabolome that appear as a result of malignant and pre-malignant lesions in the colon and …
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Regulatory roles of endothelial cells in cancer
… and tissue engineering and extends the view of tumor vessels from perfusing tubes to delivery platforms lined with potent paracrine regulatory cells. We focus on how the endothelial cells themselves regulate tumor biology in a state-dependent fashion. We found that healthy endothelial cells …
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Quantitative Dwi As An Early Imaging Biomarker of The Response to Chemoradiation In Esophageal Cancer
… surgical resection. Histopathology of resected tumors reveals that pathological complete response (pCR) is achieved in 20-30% of patients through nCRT alone. Because of the high mortality and morbidity associated with esophagectomy, it may be advantageous for patients exhibiting pCR from nCRT …
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Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
Solid tumors are composed of cancer cells, as well as resident or infiltrating non-malignant cells that contribute to the malignant state in an ecosystem generally accepted as the tumor microenvironment. Microenvironmental tumor hypoxia is the foremost leading cause of angiogenesis, i.e. the …
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Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression
… accounts for nearly 50% of all malignant brain tumors. Prognosis for GBM is grim, as the median survival time is approximately 15 months and the five-year survival rate is 10%. The challenge in treating GBM is a product of intratumoral heterogeneity and a pro-tumorigenic microenvironment. …
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