Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Tumor Targeting"”.
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Non-traditional platinum compounds for improved cellular accumulation and tumor targeting
… for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration of non-traditional platinum compounds, which do not necessarily contain the canonical ligand set of two labile leaving groups and two …
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In vitro and in vivo approaches to tumor targeting by phage display
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Approximately 30% of breast cancers are linked with the over-expression of ErbB2. Because of its critical role in signal transduction, the progression of breast cancer and its localization on the surface of several types of …
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NANOTECHNOLOGICAL APPROACHES FOR CANCER DIAGNOSIS, TREATMENT AND MANAGEMENT: IMPLEMENTATION OF FERRITIN PROTEIN NANOPARTICLES FOR TUMOR TARGETING
… in North America and Europe reveal that tumors still represent the second cause of death. In fact, the effectiveness of many drugs is often seriously affected by lack of specificity in hitting the therapeutic target, determining the onset of toxicity issues. In this context, Nanomedicine …
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Engineering Tumor-Targeting Bacteria and Characterizing Their Interactions with Tumor Cells in Therapy-Resistant Breast Cancers
… or resistant ER+, and Luminal B tumors. For these high-risk subtypes, molecular heterogeneity undermines targeted therapies, and clinical management still relies on maximum tolerable doses of systemic chemotherapy, causing severe dose-limiting toxicities. Moreover, the dense …
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
… conjugates of anticancer drugs with cancer- targeting peptides using established biomarkers of cancer such as the integrin receptor and extra-domain of fibronectin (EDB-FN) at the extracellular matrix. In the first studies, a series of targeting peptides targeting EDB-FN were synthesized and …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… and allow for the development of ligand-directed targeting strategies of the brain. Here we show the identification of a peptide mediating systemic targeting to the normal brain and to an orthotopic human glioma model. We demonstrate that this peptide functionally mimics iron through an allosteric …
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Biomanufacturing of Bacteria-Mediated Drug Delivery Systems and Investigation of Their Interaction with the Tumor Microenvironment
… of conventional chemotherapy within the tumor microenvironment (TME) is due to irregular vascularization, increased tumor interstitial pressure, and a dense extracellular matrix (ECM). The lack of selectivity of anticancer drugs often leads to systemic toxicity and damage to healthy …
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Chemical and Biological Strategies for Improving the Sensitivity of SPIO-Enhanced MR Imaging
… offer an especially attractive platform for tumor targeting, owing to their strong magnetic properties, high degree of biocompatibility and ease of post-synthesis functionalization. One of the only limiting factors to these nanoparticles is the relatively poor sensitivity of MRI (i.e. the …
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Engineering layer-by-layer nanoparticles for the targeted delivery of therapeutics to ovarian cancer
… a small library of LbL NPs that screen for tumor-targeting properties on ovarian cancer cells, both in vitro and in vivo. Our results demonstrate that ovarian cancer cells have a high affinity to carboxylated LbL NPs, and we report several tumor-targeting formulations with distinct …
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DEVELOPMENT OF A NOVEL CLASS MULTIMODALITY NANOPARTICLE AND CYTOTOXIC CONJUGATE FOR CANCER THERAPY
… therapy remains in the lacking of efficient targeting of the malignant cells without causing significant systemic toxicity. Most of the clinically used cancer therapeutic agents circulates throughout the body causing sever damage including vital organ such as brain, liver, kidney limiting …
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Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy
… 64Cu-CB-TE2A-Y3-TATE had the most favorable tumor targeting properties. The introduction of ionizable linker groups could not remedy the slow clearance from the kidney, and other modifications will be necessary to resolve this issue. The emerging idea of using the copper-64-labeled …
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Augmenting Natural Killer cell antibody binding to enhance ovarian and prostate tumor cell killing via ADCC
… are cytotoxic lymphocytes that rapidly kill tumor cells via antibody-dependent cell-mediated cytotoxicity (ADCC). ADCC is exclusively mediated by the IgG Fcγ receptor (FcγR) CD16A, and many clinically successful therapeutic monoclonal antibodies (mAbs) utilize ADCC as a mechanism of action to …
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Improving methods for cytokine immunotherapy of cancer
Cytokine therapy can activate potent antitumor responses, yet collateral toxicity often limits dosages. Although immunocytokines have been designed with the intent to localize cytokine activity, systemic dose-limiting side effects are not fully ameliorated by attempted tumor targeting. In the first …
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Turning stealth liposomes into cationic liposomes for anticancer drug delivery
<p>Targeting the anticancer agents selectively to cancer cells is desirable to improve the efficacy and to reduce the side effects of anticancer therapy. Previously reported passive tumor targeting by PEGylated liposomes (stealth liposomes) have resulted in their higher tumor accumulation. However …
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Layer-by-Layer Nanoparticles for Targeted Delivery and Treatment of Ovarian Cancer
… lesions, complete surgical removal of solid tumor may be impossible. Adjuvant chemotherapy is often associated with significant dose-limiting systemic toxicities, and can lead to platinum-resistant disease. To date, there are no FDA-approved therapies that significantly prolong the overall …
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Discovery of Pyrimidine-based Heterocycles as Single Agents With Combination Chemotherapy Potential And As Inhibitors Of Purine Nucleotide Biosynthesis For The Treatment of Cancer
… This dissertation also describes selective tumor targeting with 5-substituted pyrrolo[2,3-<em>d</em>]pyrimidines analogs with heteroatom bridge substitution<strong> </strong>as GARFTase inhibitors.<strong></strong></p> <p>The work in this dissertation is centered on identifying structural …
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Distribution and metabolism of antibodies and macromolecules in tumor tissue
Tumor targeting drugs that selectively treat cancerous tissue are promising agents for lowering the morbidity and mortality of cancer. Within this field, antibody treatments for cancer are currently being developed for both imaging and therapeutic applications. A major limitation with this class of …
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Engineering functionalized gold nanoparticles as a molecular-specific contrast agent to enhance optoacoustic detection of breast cancer cells
Molecular targeting of malignant tumors is a promising field of research that could potentially revolutionize the diagnosis and treatment of many types of cancer including breast. Delivering molecular specific contrast agents to breast cancer cells would enhance the sensitivity and specificity of …
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Targeted 177 Lu antisense radiotherapy of B-cell non-Hodgkin's lymphoma
… the mass of the compound necessary to saturate tumors, providing maximal compound uptake and antisense potential. Biodistribution data showed specific tumor targeting of the radiolabeled PNA-peptide in Mec-1 xenografts, which was compared to the radiolabeled peptide [superscript …
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