Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Tumor Suppressors"”.
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Chemical Genetic Studies of Tumor Suppressors in the Developing Zebrafish
The zebrafish is a powerful disease model system. Its distinct advantages allow it to be used for high-throughput genetic and chemical screens with high translational potential. One mutant isolated from a screen for cell cycle deficiencies is the zebrafish cdc25a mutant standstill. This mutant …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… hepatic-specific functions in development and tumor suppression. Despite a growing list of p53/p73 target genes, very few of these have been studied in vivo, and the knowledge regarding functions of p53 and p73 in normal tissues remains limited. p53+/-p73+/- mice develop hepatocellular …
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A cancer screen in zebrafish identifies many ribosomal proteins as haploinsufficient tumor suppressors
… displayed early mortality and externally visible tumors. Among such tumor-prone lines identified was one in which the known human tumor suppressor gene, neurofibromatosis type 2 (NF2), was mutated. This validated the screening approach, as well as confirmed the human relevance of the zebrafish …
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… to the insidious nature of these malignancies, tumors are not typically detected until late in the disease. Further, the delicate nature of surrounding normal brain tissue makes surgery and treatment with cytotoxic chemotherapeutics detrimental to the patient's quality of life. Despite decades …
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SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer
… states, often leading to the ablation of tumor suppressors. Loss of tumor suppressor function has been established as a driver of disease progression in breast cancer patients. Thus, understanding the deregulation of tumor suppressor activity may lead to the identification of potential …
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Novel Posttranslational Modification In Lkb1 Activation and Function
… has come to attention is that many oncogenes and tumor-suppressors are intimately linked to metabolic regulation (Jones and Thompson, 2009). One of the key tumor-suppressors involved in metabolism is Liver Kinase B1 (LKB1). LKB1 is the major upstream kinase of the evolutionarily conserved …
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Novel genomic technologies and molecular diagnostics in Colorectal Cancer
… elucidate the genetic alterations involved in tumor onset and progression. In this study 51 CRC patients were subdivided into groups according to the presence of microsatellite instability (MSI) and chromosomal instability (CIN). Of the 51 CRCs, 13.73% were MSI and 86.27% were microsatellite …
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Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts
… requires the combined inhibition of the tumor suppressors p53 and pRb. These results suggest that the molecular requirements for the induction of angiogenesis differ significantly between carcinomas and sarcomas.
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… including binding to proto-oncogenes and tumor suppressors to regulate cell death. Here we show that the IP3R binds to the tumor suppressor BRCA1. BRCA1 binds directly to the IP3R and causes destabilization of the IP3R closed state resulting in an increased open probability and increased …
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Defining the functions of a conserved hydrophobic domain in the ARF tumor suppressor
The INK4A-ARF locus encodes two tumor suppressors; p16 and p19Arf, both of which restrain cell growth by regulating the functions of Retinoblastoma (Rb) and p53 respectively. Throughout development, p19Arf is kept at minimal levels, but under conditions of oncogenic stress, p19Arf expression is …
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A Cell-Based Model to Study Factors that Drive Diffuse Astrocytoma Development
… Acquisition of additional mutations in tumor suppressors such as p53 and/or ATRX likely leads to tumor initiation. Work in the Wells Laboratory has found that loss of the HIPPO adaptor protein AmotL1 is also associated with increased malignancy. AmotL1 inhibits the transcriptional …
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Hidden Markov Model inference copy number change in array-CGH data
… the discovery of potential novel oncogenes and tumor suppressors. Recently, array based competitive genomic hybridization (array-CGH) has become available as a powerful approach for genome-wide detection of DNA copy number changes. Array-CGH assesses DNA copy number in tumor samples through …
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
… one of the most malignant forms of primary brain tumors, is characterized by its highly heterogenous genetic composition, aggressive infiltration of surrounding tissue, and resistance to current treatments. Gene expression analysis has characterized GBM into four main types, with a significant …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
<p>During the process of tumorigenesis, inactivation of tumor suppressors is a critical step. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and the enzymatic core subunit of polycomb repressive complex 2 (PRC2), promotes cell growth and migration through catalyzing trimethylation …
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Mechanistic and Therapeutic Insights for Epigenetic Regulation in Cancer Development
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are highly aggressive sarcomas that develop sporadically or in patients with Neurofibromatosis type 1 (NF1). Effective treatment options are lacking, and MPNSTs are typically fatal. To gain insights into MPNST pathogenesis, we utilized a novel MPNST …
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Colon Cancer Initiation and Progression
… Given that a common early perturbation in solid tumor initiation is bypass of matrix-dependent proliferation restraints we sought to functionally interrogate candidate colorectal cancer genes (CAN-genes) to identify driver tumor-suppressors. We have developed an isogenic human colonic epithelial …
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Preneoplastic hepatocyte hypothyroidism underlies hepatocellular carcinoma progression
… factors. THRs have also been implicated in tumorigenesis, although it is unclear whether they act as oncogenes or tumor suppressors. Here, experiments were performed to determine the role of THRs in hepatocellular carcinoma development. Using the Resistant-Hepatocyte model (RH model) of rat …
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The Role of LKBI Tumor Suppressor in Endometrial Cancer
… this role was not anticipated based on the tumor spectrum observed in Peutz Jegher women, many tumor suppressors have been found to have a much broader role in cancer than would have been predicted on the tumor spectrum associated with the hereditary syndrome. The studies that comprise this …
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The characterization of the ABF-1 promoter
… development and has been shown to function as tumor suppressors. To date, an E2A-interacting bHLH transcription factor largely restricted to activated B lymphocytes, called ABF -1, was isolated using the two-hybrid system. ABF -1 is the only B cell restricted bHLH protein isolated. ABF-1/E2A …
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Regulation of the Arf tumor suppressor by E2F transcription factors
Effective tumor suppression requires the appropriate function of two major signaling pathways, the pRB-E2F growth-control pathway and the p53 stress-response pathway. Members of the E2F family of transcription factors are key downstream targets of the retinoblastoma protein, pRB, and mediate the …
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