Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Tumor Suppressor Protein p53"”.
-
p53 in a Genetic Model: Illuminating Adaptive Radiation Responses
… cells are challenged by genotoxic stress, the tumor suppressor protein p53 promotes adaptive responses, including cell cycle arrest, DNA repair, or apoptosis. How these distinct fates are specified through an action of a single protein is not known. To study its functions in vivo we produced a …
-
Towards the Understanding of Fluorescence Quenching Mechanisms : Molecular Dynamics Simulations of Dye-Quencher Interactions in Biomolecular Systems
The presence of antibodies directed against p53 in human blood serum is a specific and independent marker of cancer. The present thesis is a simulative study of two fluorescent dyes (rhodamine 6G and MR121) used in the development of fluorescence-based immunoassays for the detection of p53 …
-
Phosphoserine Incorporation into the Intrinsically Disordered N-terminal Domain of the p53 Tumor Suppressor Protein
Protein phosphorylation is used biologically as a mechanism to control many critical life processes. Since phosphorylation usually occurs within protein regions that are intrinsically disordered, quantitative and structural descriptions of phosphorylation effects in intrinsically disordered …
-
Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway
… is an evolutionarily conserved serine/threonine protein kinase that is activated in response to DNA double strand breaks. Upon activation by the DNA damage transducer kinase, ATM, CHK2 phosphorylates a wide variety of down stream effectors to promote cell cycle arrest, DNA repair and apoptosis. …
-
Circadian Control of Cell Cycle Progression
Tumorigenesis is the result of uncontrolled cell growth due to the deregulation of cell cycle checkpoints 1. Period 2 (Per2) is a tumor suppressor that oscillate in expression in a 24-hour cycle 2, 3. Here, we show that Per2 interacts with the tumor suppressor protein p53. Both G1 and G2 checkpoint …
-
Interplay Between P53 and Epigenetic Pathways in Cancer
The human TP53 gene encodes the most potent tumor suppressor protein p53. More than half of all human cancers contain mutations in the TP53 gene, while the majority of the remaining cases involve other mechanisms to inactivate wild-type p53 function. In the first part of my dissertation research, I …
-
Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy
… 64Cu-CB-TE2A-Y3-TATE had the most favorable tumor targeting properties. The introduction of ionizable linker groups could not remedy the slow clearance from the kidney, and other modifications will be necessary to resolve this issue. The emerging idea of using the copper-64-labeled …
-
MUTANT P53 AS A THERAPEUTIC TARGET IN CANCER
Identifying therapeutic approaches to target TP53 mutations has the potential to revolutionize cancer treatment. TP53, the gene that encodes the prominent tumor suppressor protein p53, is mutated and inactivated in half of sporadic human tumors. Additionally, individuals who harbor germline TP53 …
-
Function and Properties of groE Chaperonins in Bacterial and Mammalian Cells
… most polypeptides <em>in vivo</em>, and protect proteins against aggregation when a cell is under stress. The GroESL proteins of <em>Escherichia coli</em> are the best characterized of the ringed chaperones, or chaperonins. Chaperonins of the eukaryotic cytoplasm interact with a limited number of …
-
Phospho-regulation and metastatic potential of Murine Double Minute 2
… (Mdm2) is a highly modified and multi-faceted protein that is overexpressed in numerous human malignancies. It engages in many cellular activities and is essential for development since deletion of mdm2 is lethal in early stages of embryonic development. The most studied function of Mdm2 is as …
-
Investigation of physical principles of protein phase transitions
Protein phase transitions, including liquid-to-solid aggregation and liquid-liquid phase separation, are fundamental processes underlying neurodegenerative disorders such as Alzheimer’s (the Aβ peptide and the tau protein), Parkinson’s (the α-synuclein protein), and Huntington’s diseases (the Htt …
-
Neurological Consequences of Viral Encephalitis: Behavioral Deficits, Neuronal Restructuring, and Therapeutic Interventions
… A key therapeutic focus of this study is the tumor suppressor protein p53, a pivotal regulator of apoptosis and cellular stress responses. Activating p53 using the small molecule inhibitor NVP-CGM097 resulted in significant inhibition of VEEV infectious titers. Secondly, we investigated the …
-
In Vivo Significance of The Mdm4 and P73 Interaction During Development and Tumorigenesis
<p>The tumor suppressor protein p53 is negatively regulated by Mdm4 protein. The significance of such regulation was determined from mouse models. Mdm4-deficient mice are embryonic lethal at E7.5 in a <em>p53</em>-dependent manner. p73, a member of the p53-family, is a transcription factor with …
-
P53 Genes Act to Restrain Mobile Elements
Oncogenic stress provokes tumor suppression by p53 but the extent to which this regulatory axis is conserved remains unknown. Using a biosensor to visualize p53 action, we find that Drosophila p53 is selectively active in gonadal stem cells after exposure to stressors that destabilize the genome. …
-
Interlocking mechanisms regulating the circadian clock response to DNA damage
… core clock component PERIOD2 (PER2) binds to the tumor suppressor protein p53, a key regulatory checkpoint component that modulates cell cycle progression and the cellular response to genotoxic stress. PER2 binding to p53 modulates p53's stability, cellular localization, and transcriptional …
-
Therapeutic targeting of the ATP7A copper transporter in cancer
… kinase activity of MEK1/2 and ULK1/2, promoting tumor growth in BRAF- and KRAS-driven cancers. Cu has also been reported to induce unfolding of the tumor suppressor protein p53 and to drive invasion and chemoresistance in various cancer types. The heightened metabolic demand for Cu in cancer …
-
A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Cellular Senescence
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Transcriptional and Post-Transcriptional Regulation of Retroelements
… DNA methylation. Our lab has demonstrated that p53 can also transcriptionally repress retroelements, however, the mechanism by which p53 mediates repression was unknown. Due to the repetitive nature and large copy numbers of endogenous retroelements, it is challenging to study how individual …
-
In Vivo Genome-Wide Analyses of the Drosophila p53 Transcriptional Network
p53 is the most commonly mutated gene in human cancers. Despite decades of p53 studies we do not fully understand how p53 suppresses tumors. Similar to human p53, the Drosophila counterpart is a transcription factor that can respond to genotoxic stress and promote adaptive responses at the cellular …
Page 1 of 2