Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Tumor Spheroids"”.
-
Advancing Dynamic Imaging for Microfluidic Stimulated Tissues: Biology, Techniques, and Applications
… pancreatic islets and three-dimensional in vitro tumor spheroids on a custom microfluidic platform provides real-time physiological and biological information with subcellular resolution. Using this microfluidic stimulated tissue platform, we developed a novel imaging method relating the …
-
Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer
… binding kinetics, diffusion and catabolism in tumor spheroids, and radiation dosimetry models for alpha- and beta-emitting radionuclides. This model demonstrated that it is theoretically possible to kill every cell in 100 tm radius micrometastases using 9Y- or 213Bi-based PRIT with acceptable …
-
Distribution and metabolism of antibodies and macromolecules in tumor tissue
Tumor targeting drugs that selectively treat cancerous tissue are promising agents for lowering the morbidity and mortality of cancer. Within this field, antibody treatments for cancer are currently being developed for both imaging and therapeutic applications. A major limitation with this class of …
-
Biomanufacturing of Bacteria-Mediated Drug Delivery Systems and Investigation of Their Interaction with the Tumor Microenvironment
… of conventional chemotherapy within the tumor microenvironment (TME) is due to irregular vascularization, increased tumor interstitial pressure, and a dense extracellular matrix (ECM). The lack of selectivity of anticancer drugs often leads to systemic toxicity and damage to healthy …
-
Fluid Shear Stress Effects on Cancer Metastasis
… metastatic events but its effects on circulating tumor cells (CTCs) remains a mystery. It is known that shear stress can act either directly, causing membrane rupture and cell death, or by altering cell phenotype via mechanotransduction pathways, but to what extent these and other unknown effects …
-
Rational Engineering of Bacteria and Biohybrids for Enhanced Transport and Colonization in the Tumor Microenvironment
… is poor delivery to and transport within the tumor microenvironment (TME), caused by irregular and leaky vasculature, the lack of functional lymphatics, and underscored by the overproduction of extracellular matrix (ECM) proteins such as collagen. Coupled with limited specificity, the high …
-
Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors
… tissues and concentration of the drug within the tumor. As such, encapsulation of chemotherapeutic agents inside nanoparticles capable of enhancing tumor-targeted drug delivery is a particularly promising innovation. Yet, initial investigations into the intratumoral fate of nanomedicines have …
-
Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… by culturing mammary epithelial cells as 3D spheroids embedded in a reconstituted basement membrane. I first used this assay to characterize the role of cell-cell and cell-ECM adhesion in the formation and polarization of the apical junction complexes in normal mammary epithelial cells. …
-
Overcoming radioresistance by targeting p21 in cancer
… challenge in the eradication of human malignant tumors. Hence, understanding the molecular mechanisms at the base of radioresistance is crucial to improve effectiveness of therapy. Radiation induced tumor regression is driven by DNA damages production and activation of downstream cellular …
-
Engineering antibodies for improved targeting of solid tumors
… due to their ability to specifically bind tumor-expressed antigens. Unfortunately, attempts to treat solid tumors with these drugs are often limited by an inability of the antibodies to fully penetrate the tumor tissue, leaving large regions of untargeted and viable cells. The goal of this …
-
The cholesterol efflux protein ABCA1 skews macrophages towards an anti-tumor phenotype and consequently impacts cancer progression
… the impact of cholesterol homeostasis in tumor-associated macrophages on breast cancer progression. An in-depth computational screen helped us pinpoint ABCA1—a cholesterol efflux protein whose elevated mRNA expression is linked to increased survival. In addition to efflux, ABCA1 can also …
-
The Tumor Microenvironment Regulates Retinoblastoma Cell Survival
… in children comprising 4% of all pediatric tumors. Early intervention increases survival rates up to 95% in developed countries; being survival rates associated to socio-economic status. Despite the high survival rates in developed countries, preservation of the eye and vision are continuing …