Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Tumor Regression"”.
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
… to be a clinically effective strategy to enhance tumor specific immune responses. Recently discovered novel immunoglobulin superfamily ligand V-domain Ig suppressor of T-cell Activation (VISTA) is a new target for immunotherapy. VISTA expression is specifically upregulated on tumor infiltrating …
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Investigating The Roles of P63 and P73 Isoforms to Therapeutically Treat P53-Altered Cancers
… Flores, Ph.D</strong>.</p> <p>The <em>TP53</em> tumor suppressor is mutated in approximately 50% of human cancers rendering cancer therapies ineffective. p53 reactivation suppresses tumor formation in mice. However, this strategy has proven difficult to implement therapeutically. An alternate …
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Walleye dermal sarcoma virus Orf C: a potential oncolytic therapy
… that causes the growth of multifocal, cutaneous tumors in walleye fish (Sander vitreus vitreus). These virus-induced tumors spontaneously regress on a seasonal basis. The WDSV genome encodes three accessory proteins (rv-cyclin, Orf B, and Orf C) that are necessary for regulation of virus …
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CROSS-REACTIVITY BETWEEN MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN AND ROUS SARCOMA VIRUS-INDUCED TUMOR ANTIGEN IN CHICKENS
… antigen and Rous sarcoma virus (RSV)-induced tumor associated antigen (TAA) in chickens was investigated. The B erythrocyte allcantigen locus was the genetic marker for the MHC. B2B2 and B5B5 chickens from crosses of highly inbred lines 6-1 and 15-1 and B24B24 chickens from noninbred line UNH …
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The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip
… Fas in established OS lung metastases results in tumor regression. Therefore, agents that upregulate Fas expression or activate the Fas signaling pathway may have therapeutic potential.</p> <p>Treatment of Fas<sup>-</sup> metastatic OS cell lines with 2 μM MS-275 sensitized cells to FasL-induced …
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THERMOSTABLE EXOSHELLS AS TOOLS FOR RECOMBINANT PROTEIN EXPRESSION AND IN VIVO DELIVERY
… administered tES(+)/tES-HRP results in complete tumor regression. Our findings support the potential use of thermostable shells in the therapeutic delivery of macroglobular proteins.
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Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
… CD8⁺ T cell responses, leading to significant tumor regression and prevention in a mouse tumor model. These results support αCD40-mSAs as an 'all-in-one' vaccine delivery platform with multifunctional immunopharmacological advantages and strong translational potential for personalized cancer …
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A novel nanodelivery system for combination tumor therapy
… alone have not proven effective in inducing tumor regression in the clinic due to both the cytostatic nature of anti-angiogenic therapy and the potential formation of new regions of hypoxia within the tumor after therapy. The new therapeutic paradigm is for combining both anti-angiogenics and …
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Engineering immunity : enhancing T Cell vaccines and combination immunotherapies for the treatment of cancer
… response can be stimulated to elicit durable tumor regressions in metastatic cancer, but these dramatic responses are confined to a minority of patients¹-³. This outcome is likely due in part to the complex network of immunosuppressive pathways present in advanced tumors, which necessitates …
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ELUCIDATION OF THE ROLE OF FAT10 IN TUMORIGENESIS
… Since Ubiquitin is known to be involved in tumorigensis, we hypothesized that FAT10 as an ubiquitin-like protein also played a role in tumorigensis, since FAT10 has been reported to be overexpressed in several cancers, including colorectal cancer. However, it remains unclear whether FAT10 …
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Small molecule activators of procaspase-3 as an anticancer strategy
… in the PAC-1 class are capable of inducing tumor regression in dogs with lymphoma. These results highlight the importance that zinc plays in the regulation of caspase activity and the induction of apoptosis. Studies that characterize the interaction between procaspase-3 and zinc are …
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PARP inhibition in combination with radiation therapy for the treatment of feline oral squamous cell carcinoma
… squamous cell carcinoma (FOSCC) is a devastating tumor frequently palliated with radiation therapy (RT). Disappointingly, RT typically exerts marginal and transient tumor regression and new strategies to enhance RT efficacy are needed. Poly (ADP-ribose) polymerase (PARP) is a key molecule involved …
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Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma
… antagonist, resulted T cell infiltration and tumor regression with anti-PD-L1 therapy in the KPC model. The CAMPLEX clinical trial was initiated to assess the safety of a 7-day AMD3100 infusion and provide proof-of-concept that AMD3100 reverses CXCL12 mediated immune-suppression in the TME. …
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Mechanism of acquired temozolomide resistance in glioblastoma
… After aggressive treatment, therapy resistant tumors inevitably recur. However, the molecular mechanisms underlying such resistance remain unclear. We isolated GBM cells resistant to temozolomide (TMZ), the frontline chemotherapy agent for GBM, and observed modest decreases in the mismatch …
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Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth
… promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery system consisting of an assembly of nanoparticles that can change its size to facilitate transport into solid tumors. …
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Cell-mediated immunity in Marek's disease virus-infected chickens genetically selected for high and low levels of plasma corticosterone
… non-infected HPC control chickens. Although all tumor-bearing chickens demonstrated a markedly suppressed LT response, LPC chickens demonstrated a greater LT response than did HPC chickens. Relative to steroid level chickens infected with MDV, but without tumors, demonstrated a suppressed LT …
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TARGETING CANCER METABOLISM WITH FASTING-MIMICKING DIET¿BASED LOW-TOXIC COMBINATION THERAPIES: OVERCOMING RESISTANCE THROUGH METABOLIC SYNERGY
… in up to 25–30% of lung adenocarcinomas. Tumors harbouring this mutated oncogene are particularly resistant to targeted therapies, highlighting the need for novel targeted low-toxicity strategies. Nutrient restriction interventions, such as fasting and fasting-mimicking diets (FMD), …
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Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy
<p>Unprecedented durable tumor regression can be achieved in patients with checkpoint blockade immunotherapy, yet these responses are rare and are not observed in all tumor types. Castration resistant prostate cancer (CRPC) and pancreatic adenocarcinoma (PDAC) are two common lethal cancers that …
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MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) VS NON-MHC INFLUENCES ON RESPONSE TO RSV-INDUCED TUMORS IN CHICKENS
… on the fate of Rous sarcoma virus (RSV)-induced tumors. However, noninbred chickens with identical B genotypes and inbred lines indistinguishable at the MHC have demonstrated considerable variation in response to RSV challenge. The major objective of this research was to determine the cause of …
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Experimental brain tumors, dendritic cells and immunotherapy
… astrocytomas are the most common primary tumors of the adult central nervous system. Surgical resection of tumor mass in combination with radiotherapy and chemotherapy is only palliative and there is a clear need for new and more effective therapeutic strategies. The aim of this study was …
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