Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Tumor Microenvironment (TME)"”.
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PROGRAMMED ADDICTION OF PANCREATIC CANCER TO NUCLEOTIDE METABOLISM BY THE TUMOR MICROENVIRONMENT
… growing malignancy, yet PDAC cells face a harsh tumor microenvironment (TME) of poor nutrient availability. To adapt, they were shown to exploit stellate cells, the predominant stromal cells, for growth-promoting nutrients. However, there is inadequate understanding of tumor-stellate cells …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
The immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine …
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Single cell and spatial analysis characterize metabolic DPEP1+ fibroblasts in PDAC
… progression patterns, resists conventional treatments, and poses significant challenges to patient survival, necessitating urgent research and development of novel therapeutic approaches. Understanding cancer-associated fibroblasts (CAF) metabolism reprogramming in PDAC tumor microenvironment …
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The influence of nutrient availability on tumor metabolism
Tumor growth and progression are profoundly influenced by nutrient availability in the tumor microenvironment (TME). Nutrient accessibility not only shapes cancer metabolism but also affects therapeutic responses, genetic dependencies, and metastatic behavior. This dissertation explores how …
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Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
… revealed significant heterogeneity in the tumor microenvironment (TME) characterized by a diversity of cancer-associated fibroblasts, immune cells, and endothelial cell populations. Notably, we identified different CAF subtypes, including inflammatory (iCAFs), matrix(mCAFs), complement …
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Effects of m6A DNA methylation by bacterial methyltransferase in colorectal cancer
… clade of Fna is primarily enriched in the tumor microenvironment (TME) and within colorectal cancer (CRC) cells. This clade DNA methylation pattern is primarily catalyzed by a cell-cycle regulated methyltransferase (CcrM) ortholog, M.FnI, that targets the GANTC sequence motif through …
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Fibroblast Heterogeneity In Pancreatic Cancer Immunity
… contradictions as to the roles CAFs play in the tumor microenvironment (TME). CAFs were thought to be a barrier to treatment of pancreatic ductal adenocarcinoma (PDAC). However, general stromal targeting strategies have largely failed in the clinic likely due to the heterogeneity of CAFs in the …
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Influence of Fibroblasts on Metastatic Cancer Cell Drug Resistance in a 3D Microfluidic Cell Array
<p>Modeling an accurate depiction of the tumor microenvironment, (TME), is essential to observe the effect external factors might have on the tumor <em>in vivo.</em> In cancer therapy specifically, the outcomes of clinical treatments are heavily dependent on drug testing methods despite the …
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LINOLEIC ACID UNLEASHES THE ANTI-TUMOR POTENTIAL OF CD8 T CELLS BY PROMOTING METABOLIC REPROGRAMMING
… unprecedented clinical results in the treatment of cancer, but scarce intra-tumor infiltration, persistence and function of adoptively transferred T cells limit its efficacy, especially in solid tumors. Metabolic constraints imposed by the tumor microenvironment (TME) greatly influence the …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… of the adenomatous polyposis coli (APC) tumor suppressor is</p> <p>common genetic event across many cancers and serves a critical initiating</p> <p>event in the majority of sporadic colorectal cancers (CRC). The WNT/APC</p> <p>pathway remains an elusive target for cancer, prompting us to …
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A HIF-INDEPENDENT PROGRAM SUSTAINS TUMOR TREG FUNCTION IN OXYGEN-DEPRIVED ENVIRONMENTS
The immune-suppressive tumor microenvironment (TME) is both hypoxic and enriched with Treg. Their function in hypoxia has been poorly characterized. Definition of Treg responses to hypoxia would enable their selective targeting in cancer therapy, bypassing potential systemic adverse effects. We …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
… part due to the presence of an immunosuppressive tumor microenvironment (TME), driven by a highly desmoplastic stroma in mBC. For my dissertation, I explored strategies to re-engineer the desmoplastic TME to overcome therapeutic resistance to immune checkpoint blockade (ICB), and developed an …
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Potentiation of The Immune Checkpoint Blockade Response By Metabolic Modulation Is Predictable Using Molecular Imaging
… of cancer. The high metabolic needs of the tumor cells result in nutrient depletion and produce a hostile tumor microenvironment (TME) for antitumor immune cells, protecting the tumor from immune cell-mediated control and immunotherapy. Two of these environmental factors, acidosis and …
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Biomanufacturing of Bacteria-Mediated Drug Delivery Systems and Investigation of Their Interaction with the Tumor Microenvironment
… of conventional chemotherapy within the tumor microenvironment (TME) is due to irregular vascularization, increased tumor interstitial pressure, and a dense extracellular matrix (ECM). The lack of selectivity of anticancer drugs often leads to systemic toxicity and damage to healthy …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
<p>Oncolytic HSV-1 (oHSV) treatment induces Notch signaling and myelosuppression in the tumor microenvironment (TME) of preclinical models. In the clinic, upregulation of JAG1 gene expression was observed in recurrent high-grade glioma patients treated with CAN-3110. Since JAG1 is expressed on both …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
… precision cancer therapeutics, but current treatment options are limited and not curative. Recently, our lab reported that adoptive <em>PTEN</em> downregulation in metastatic breast tumor cells activates PI3K/NF-ƙB signaling and increases the secretion of the chemokine CCL2, which enhances the …
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… experience recurrence and subsequent treatment resistance. Immunotherapies have shown limited efficacy against HGSC, which is partly attributed to the presence of immunosuppressive cytokines in the tumor microenvironment (TME), notably transforming growth factor beta (TGF-β). TGF-β …
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LINKING HISTONE LACTYLATION TO THE EPIGENETIC REPROGRAMMING OF CD4+ T REGULATORY LYMPHOCYTES IN THE TUMOR ECOSYSTEM
Tumor infiltrating regulatory T cells (TI-Tregs) exhibit a complex interplay with various cell types, including tumor cells, immune cells, and stromal cells thereby promoting tumor growth and invasion. TI-Treg are transcriptionally and epigenetically adapted to the hostile tumor microenvironment …
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Role of Il-17/Il-17Ra Signaling In The Pancreatic Tumor Microenvironment
… of a highly immunosuppressive fibro-cellular tumor microenvironment (TME). Our research has revealed the important role of IL-17 in the development and progression of pancreatic cancer, yet the specific cellular compartment responsible for IL-17-mediated tumor promotion remains unknown. We …
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting evidence indicates that, besides current known immune …
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