Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Tumor Initiating Cells"”.
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TARGETING METABOLIC PLASTICITY OF GLIOBLASTOMA TUMOR INITIATING CELLS TO RESTORE SENSITIVITY TO LSD1-DIRECTED THERAPY
… traits are sustained by the existence of tumor-initiating cells (TICs) that are able to adapt and survive in the different GBM microenvironments. TICs plasticity is under the control of epigenetic modifications that, among others, regulate metabolic genes' expression. We have recently …
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Marker-Free Isolation and Enrichment of Rare Cell Types Including Tumor Initiating Cells through Contactless Dielectrophoresis
… systems (µTAS) is the separation of circulating tumor cells (CTCs) from body fluids. Cancer cells spread from the initial site of a tumor by first invading the surrounding tissue, then by entering the blood or lymph vessels, and finally by crossing the vessel wall to exit the vasculature into …
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Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
… Multiforme (GBM) is an aggressive brain tumor, characterized by high cellular heterogeneity, is refractory to treatment and has dismal prognosis. These characteristics of GBM have suggested the presence of stem-like cells that have the ability to initiate and maintain tumors of a …
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Targeted Oncolytic Virotherapy Using Newcastle Disease Virus Against Prostate Cancer
… and radiation. Hormone independent cancer stem cells escaping conventional therapy present a major therapeutic challenge. The available treatment regimens for hormone resistant CaP are only palliative and marginally increase survival. Therefore, novel strategies to eradicate CaP including stem …
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Aminoflavone Inhibits α6-integrin and Growth of Tamoxifen Resistant Breast Cancer
… often promotes metastasis, recurrence and death. Tumor-initiating cells (TICs) represent key contributors to resistance and adhesion protein α6-integrin is a putative TIC biomarker. Investigational agent Aminoflavone (AF) demonstrates efficacy against breast cancer cells irrespective of ER status. …
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New therapeutic and diagnostic strategies in glioblastoma: Cancer Stem Cells targeted by monoclonal antibody
… oncology is the identification of new specific tumor target to design effective therapies. At present it is widely accepted that the tumors are originated from a undifferentiated cell population able to trigger the cancer establishment and responsible for its maintenance. These undifferentiated …
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Novel Regulation of the Cell Cycle During Cell Fate Decisions in the Central Nervous System
Mitotically active cells at the sites of neurogenesis and primitive cells of the sympathetic nervous system are speculated to act as a source of stem-like tumor initiating cells (TICs) in neural cancers like glioma and neuroblastoma. Understanding how normal neural stem and progenitor cells …
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Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
… Many types of cancer stem and progenitor cells, including breast, have demonstrated EZH2 to be fundamental in the biology and promoting the expansion of their cellular populations. How EZH2 regulates each of these respective tumor initiating cells (TICs) populations has been studied, but …
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MULTI-OMIC LINEAGE TRACING PREDICTS THE MOLECULAR DRIVERS OF CANCER STEM CELLS IN TRIPLENEGATIVE BREAST CANCER EVOLUTION.
… to the intrinsically heterogeneous and highly tumorigenic TNBC cell line SUM159PT, we identified two distinct subpopulations: drug-tolerant cells (DTCs) and tumor-initiating cells (TICs). DTCs are marked by a genomic alteration on chromosome 11 that confers reduced sensitivity to cytotoxic …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… generation therapies. We demonstrate that cancer cells co-opt anti-viral signaling to sustain genetic programs that drive resistance to multiple anti-cancer modalities. In the context of radiation resistance, upon heterotypic interaction, exosomes are transferred from stromal to breast cancer …
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Microfluidic technology for cellular analysis and molecular biotechnology
… for biological analysis of a low number of cells. The technological advances in microfluidics have allowed both forming of valves, mixers and pumps and integrating of optic and electronic components into microfluidic devices to construct complete and functional systems. In this dissertation, …
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Lab on a chip rare cell isolation platform with dielectrophoretic smart sample focusing, automated whole cell tracking analysis script, and a bioinspired on-chip electroactive polymer micropump
… across the channel. The cDEP platform sorts cells based on intrinsic biophysical properties, is inexpensive, maintains a sterile environment by using disposable chips, is a rapid process with minimal sample preparation, and allows for immediate downstream recovery. This platform is highly …
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Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis
… BBB and this process is considered to involve tumor-secreted proteinases. We analyzed clinical significance of 21 matrix metalloproteinases on brain metastasis-free survival followed by verification in brain metastatic cell lines and found that only MMP1 is significantly correlated with brain …
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Targeting survival pathways in cancer stem cells
The discovery of tumor-initiating cells endowed with stem-like features, and therefore referred to as cancer stem cells (CSCs), has added a further level of complexity to the pathobiology of neoplastic diseases. This uncommon cellular subpopulation has been connected with tumor initiation, …
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Characterization of Metabolic Differences in Benign, Slow Developing and Tumor Initiating Ovarian Cancers
… an altered metabolic state within cancer cells known as the Warburg effect. In the Warburg effect, cancer cells participate in an increased rate of aerobic glycolysis with an excess secretion of lactate, allowing for carbon flux into biosynthetic pathways. Exactly which metabolic pathways …
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The hybrid epithelial/mesenchymal phenotype and its implications in cancer metastasis
… of cancer-related deaths occur because cancer cells metastasize, i.e. invade the surrounding tissue, travel throughout the body, and form tumors at distant organs. Metastasis is often fueled by Epithelial-to-Mesenchymal Transition (EMT) that enables cells to migrate and invade, and its reverse …
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Vulnerability to G - Quadruplexes in BRCA2 - Null Medulloblastoma: A Protective Role for the PIF1 Helicase
… characterized by chromothripsis in p53-deficient tumors and a high level of somatic mutation in many other cases.We utilized a mouse model of spontaneous medulloblastoma development driven by BRCA2 loss in the central nervous system coupled with global inactivation of p53 to study the roles of …
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Single Cell Biomechanical Phenotyping using Microfluidics and Nanotechnology
… in an increased deformability of transformed cells and reduced resistance to mechanical stimuli, enabling motility and invasion. Therefore, single cell biomechanical properties could be served as a powerful label-free biomarker for effective characterization and early detection of single …
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Theoretical Considerations of Biological Systems in the Presence of High Frequency Electric Fields: Microfluidic and Tissue Level Implications
… manipulate, isolate, and enrich rare mammalian cells dispersed within heterogeneous populations. Relevant examples of these target cells are stem cells within a differentiated population, circulating tumor cells (CTCs) in the blood stream, and tumor initiating cells (TICs) in a population of …
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Molecular Characterization of Glioblastoma Cancer Stem Cells
… gliomas are locally aggressive, highly vascular tumors that have an overall survival time less than 14 months, and current therapies provide little improvement in the disease course and outcome. While glioblastoma multiforme (GBM) patients present uniform histological phenotypes, the molecular …
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