Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Tumor Initiating Cell"”.
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… disease challenging. In an effort to explain tumoral heterogeneity, the tumor initiating cell model (TIC) states that tumors are composed of cells that form the majority of the tumor and are terminally differentiated. This model however, attributes tumorigenesis, metastasis and chemoresistance …
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Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
<p>Hypoxia is a hallmark of most solid tumors. In response to hypoxic stress tumor cells adapt by regulating survival, metabolism and angiogenesis. The heterodimeric HypoxiaInducible Factor (HIF) transcription factors are the master regulators of this response. HIFs play key roles in many critical …
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Marker-Free Isolation and Enrichment of Rare Cell Types Including Tumor Initiating Cells through Contactless Dielectrophoresis
… systems (µTAS) is the separation of circulating tumor cells (CTCs) from body fluids. Cancer cells spread from the initial site of a tumor by first invading the surrounding tissue, then by entering the blood or lymph vessels, and finally by crossing the vessel wall to exit the vasculature into …
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TARGETING METABOLIC PLASTICITY OF GLIOBLASTOMA TUMOR INITIATING CELLS TO RESTORE SENSITIVITY TO LSD1-DIRECTED THERAPY
… traits are sustained by the existence of tumor-initiating cells (TICs) that are able to adapt and survive in the different GBM microenvironments. TICs plasticity is under the control of epigenetic modifications that, among others, regulate metabolic genes' expression. We have recently …
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CHARACTERIZATION OF EPCAM IN THYROID CANCER BIOLOGY BY THREE-DIMENSIONAL SPHEROIDS IN VITRO MODEL.
… for insensitivity to therapeutic treatments, tumor aggressiveness and tumor relapse described in undifferentiated thyroid cancers (UTCs) haven’t been fully elucidated yet. The insurgence of therapy resistance and disease relapse is believed to be due to a subpopulation of cancer cells within …