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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Tumor Immunology"”.
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The Effect of Tim-3-Ig on Tumor Growth
… but it's function has not been clarified in tumor immunity. To explore the effect of Tim pathway blockade on tumor growth using Tim-3-Ig fusion protein, two approaches were adopted. First, it was investigated whether Tim-3-Ig expression in lung carcinoma cells (3LL) affects tumor growth in …
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A study of functionalized iron oxide nanoparticles for selective recognition of kappa-casein: a breast cancer biomarker.
Kappa casein is extremely important in tumor immunology and plays a crucial role in the early detection of breast cancer. In this research, functionalized iron oxide (Fe3O4) nanoparticles were used for selective recognition of kappa casein (kcn) a breast cancer biomarker. The Fe3O4 was synthesized …
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Tumor Antigens Revealed by Exome Seqeuncing Drive Editing of Tumor Immunogenicity
… immunity cannot only function as an extrinsic tumor suppressor, but also shape tumor immunogenicity. These observations led to the development of the cancer immunoediting hypothesis that stresses the dual host-protective and tumor-sculpting actions of immunity on developing cancers. We …
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Investigating The Distinct Role of Pd-L2 In Modulating Human T Cells Responses
… treatment of multiple cancers and made durable tumor regression a possibility in the clinic. PD-1 blockade prolonged progression-free survival and overall survival with lesser high-grade toxicity in patients with advanced melanoma when compared to the other FDA-approved checkpoint blockade …
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Adoptive cell therapy using primary T lymphocytes with genetically engineered T cell receptors against melanoma and glioma
Over the past few decades, our knowledge of tumor immunology and the role antitumor immune responses play in tumor recognition and eradication has greatly increased and led to immunotherapies being investigated as a promising strategy for cancer treatment. Current clinical studies with various …
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Characterizing Changes in T Cell Composition and Function Within Prostate Tumors Following Androgen Ablation and Non-invasive Imaging of Anti-Tumor Immune Responses
… use the cells of the immune system to eradicate tumors. This is an especially attractive option for the treatment of androgen independent prostate cancer because as an immunogenic, non-vital organ, collateral prostate tissue damage is not life threatening. We set out to characterize the prostate …
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Immunotherapy against malignant brain tumors - of mice and men
… most abundant and most aggressive primary brain tumor in adults. Due to the infiltrative growth of the tumor, surgery will never be radical. Radiation and chemotherapy only marginally improve the poor prognosis due to the ability of the GBM to develop resistance towards these treatments. …
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The Tumor-Suppressive Properties of Neural Stem Cells
… of neural stem cells (NSCs) towards the tumor. This migration reflects the NSC wound repair response following CNS injury. Studies using NSCs surgically implanted into GBM tumors showed decreased tumor growth and increased animal survival in mice; however, the mechanisms underlying these …
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Das Protein La/SS-B: Vom Autoantigen zur Zielstruktur für die Immuntherapie
… Infektion simulierten. Die Immuntherapie von Tumoren ist auf bestimmte Zielstrukturen auf den Tumorzellen angewiesen, über welche die Wirkstoffe spezifisch zu den maligne transformierten Zellen gebracht werden. Die Therapeutika, die sich oft von mAks gegen diese Zielstrukturen ableiten, müssen …
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
… to be a clinically effective strategy to enhance tumor specific immune responses. Recently discovered novel immunoglobulin superfamily ligand V-domain Ig suppressor of T-cell Activation (VISTA) is a new target for immunotherapy. VISTA expression is specifically upregulated on tumor infiltrating …
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Die Rolle von Interferon-g bei der Tumorabwehr von B16GP33-Lungenmetastasen durch CD8 T-Lymphozyten
… wichtige Rolle spielen. Die Identifizierung von tumorassoziierten Anti-genen (TAA) bei Krebspatienten, die von CD8 T-Zellen erkannt werden, unterstreicht diese Beobachtung. CD8 T-Zellen alleine reichen jedoch meist nicht aus, um das unkontrollierte Wachstum der Tumorzellen zu stoppen. Es ist …
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Charakterisierung von Tumorantigenen des kutanen T-Zell Lymphoms: Serologische Immunantwort und Expressionsanalyse
… auf der Basis gut charakterisierter, tumorspezifischer Antigene stellen ein vielversprechendes Konzept der Tumortherapie dar. Ein potentielles Antigen für immuntherapeutische Strategien sollte möglichst tumorspezifisch exprimiert sein und es sollte einen Hinweis auf bereits erfolgte …
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OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
… analysis of murine intracranial melanoma tumors that pharmacologic inhibition of oxidative phosphorylation (OXPHOS) results in increased expression of genes consistent with activated anti-tumor immune responses. <strong>The central hypothesis of this dissertation is that OXPHOS plays a …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… T cell-mediated immunity against pathogens and tumors. Although the importance of cDC1s is now well established, the mechanisms that regulate cDC1 function remain largely unknown. Signal Transducer and Activator of Transcription 3 (STAT3) mediates the intracellular signaling of interleukin 10 …
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Charakterisierung monoklonaler Antikörper gegen die murine Fibrosarkomzellinie MCA102 und Rolle der B-Zellen in diesem Tumormodell
Es ist bekannt, dass B-Zellen in einigen Tumormodellen einen inhibierenden Einfluß auf <br>die Tumorimmunität besitzen. Dieser hängt sowohl mit T-Zell-B-Zell-Interaktionen als <br>auch mit den von B-Zellen produzierten Antikörpern (Ak) zusammen. Ziel der <br>vorliegenden Arbeit war es, die Rolle …
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Memory Potential, Molecular Characterization, and Translational Applications of The Novel Theo/Tceo T Cell Phenotype
… are exquisitely adapted to combat pathogens and tumors. The inflammatory environment largely dictates the nature of T cell response. A hallmark of T cell-mediated immunity is formation of immunological memory; the ability to respond more potently to re-encounter with pathogens. The immune system …
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Exploring the immunologic consequences of ATRX deficiency in glioma
… types. One of the most common ATRX-mutated tumor types is the adult-type glioma, IDH-mutant, Astrocytoma. It is known that ATRX mutation leads to increases in DNA damage, replication stress, and global epigenetic regulation at a cell level; however, less is known about the impact of ATRX …
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Unraveling The Effects of Aerobic Exercise and Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models
<p>Solid tumors are comprised of multiple cell types which communicate and work together to promote tumor progression. Advances in the treatment of solid tumors have armed clinicians with more efficacious pharmacologic agents and combinations. However, a focus on drug adjuvants in the treatment of …
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Impact Of Cryoablation On Tumor Immunity
… is a minimally invasive procedure for tumor debulking, which has the potential to initiate or amplify tumor immunity through the release of tumor-associated antigens and endogenous danger signals. However, enhanced immunity is rarely observed in treated patients, suggesting the need for …