Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 153 for “"Tumor Development"”.
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Neural Stem Cells in Brain Tumor Development
… are highly invasive and incurable brain tumors. Mouse models that genetically resemble the human disease are valuable tools in understanding the pathogenesis of these malignancies. We previously reported mouse models based on conditional inactivation of the human astrocytoma-relevant …
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The Role of HNF4A in Germ Cell Tumor Development
Yolk sac tumor is a histological category of germ cell tumors, which represent the most frequent malignancy in young men. Little is known about the molecular mechanisms responsible for the aberrant differentiation and oncogenic potential of yolk sac tumors. Multiple recurrent chromosomal copy …
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Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power
… can contribute to cancer cell survival and tumor progression. Tripartite motif-containing protein 24 (TRIM24) is an E3 ligase for p53, a nuclear receptor co-regulator, and a histone reader. Over expression of TRIM24 correlates with poor overall survival of breast cancer patients. Previously, …
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
<p>Wilms tumor is one of the most common solid tumors in children. It is an embryonic cancer of the kidney and is thought to arise from undifferentiated renal mesenchyme. However, the differentiation status of cells in the mesenchyme that can give rise to Wilms tumors is unknown. Gene expression …
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Rmi1 Is Essential For Early Embryonic Development and Attenuation of Tumor Development
… double-heterzygous mice showed shortened tumor latency and aggressive tumor types when comparing with wild type, RMI1+/- and p53+/- control cohorts. My study suggests a dual-functional role of RMI1 in early embryonic development and tumor suppression.
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
… exposures during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life in a process known as developmental reprogramming. We have shown that neonatal exposure to the xenoestrogen diethylstilbestrol (DES) can …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… affects the immune response against primary tumors, we transplanted H31m1 sarcoma cells into wildtype and TREX1D18N/D18N mice, and compared CD8+ T cell differentiation and tumor growth. We found D18N mice had greater tumor rejection and dendritic cell maturation, and their CD8+ tumor …
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Examining the roles of the pyruvate kinase isoforms, PKMI1 and PKM2, in systemic metabolism and tumor development
… functional requirement for PKM1 or PKM2 during development and tissue homeostasis, we generated germline PKM1 (Pkm1-/-) or PKM2 null mice (Pkm2-/-). Unexpectedly, despite being the primary isoform expressed in most wild-type adult tissues, we found that Pkm2' mice are viable and fertile. Thus, …
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Efficacy of tamoxifen and thymoquinone on tumor development, lipid peroxidation, and total antioxidant capacity in DMBA induced mammary carcinoma in female Sprague-Dawley rats
… However, TAM has been reported to induce liver tumors in several animal models due to overproduction of free radicals and lipid peroxidation. Thymoquinone (TQ), from Nigella sativa seeds, is a Middle East natural medicine and it has been used to treat a number of diseases, including cancer. The …
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The Effect of Dietary Fat Level on Tumor Development and Immunity in BALB/C Mice Fed Casein of Wheat Gluten as Protein and Challenged with Herpes Type 2-transformed Cells
… diet decreases the animal’s ability to restrict tumor development and growth. In previous work done in this laboratory with BALB/c mice injected with herpes simplex Type 2-transformed mouse cells (H238), the effects of a diet which greatly enhanced tumor growth was compared with one which …
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The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer
… (EPMRT) would be protective against mammary tumor development. Previously, in a mouse model of HER2+ breast cancer, our laboratory demonstrated that EPMRT was protective against mammary cancer by increasing mammary tumor latency, decreasing tumor incidence and weight, and decreasing gross …
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Dissecting the Role of ATRX in Soft Tissue Sarcoma Development and Therapeutic Response
… with alterations occurring in 29% of these tumors. However, the role of ATRX in the development and response to cancer therapies in soft tissue sarcoma remains poorly understood. Here, we developed a primary mouse model of soft tissue sarcoma and studied the effect of Atrx deletion on tumor …
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Detection of Single Nucleotide Polymorphisms In Csmd1 Gene of Colon and Breast Cancer Patients
<p>CSMD1 is a candidate tumor suppressor gene that maps to chromosome 8p23 that codes for a novel multiple domain complement regulatory and adhesion protein. To determine whether mutations in CSMD1 affected tumor development or patient outcome, we used nucleotide sequencing to identify single …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
<p>During the process of tumorigenesis, inactivation of tumor suppressors is a critical step. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and the enzymatic core subunit of polycomb repressive complex 2 (PRC2), promotes cell growth and migration through catalyzing trimethylation …
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Détection, annotation fonctionnelle et régulation des isoformes de l'épissage alternatif associées au cancer de l'ovaire
… modify their gene expression pattern to promote tumor growth. Unfortunately, current research focuses almost exclusively on global gene expression changes, without taking into account the fact that the majority of genes produce multiple alternative splicing variants, which potentially code for …
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Contrasting Effects of An Mdm2 Functional Polymorphism On Tumor Phenotypes
… levels of MDM2 concomitant with decreased p53 tumor-suppressor activity. <em>Mdm2<sup>SNP309G/G</sup></em> mice are more prone to spontaneous tumor formation than <em>Mdm2<sup>SNP309T/T</sup></em> mice, providing direct evidence for the impact of this SNP on tumor development. We examined the …
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Investigating The Roles of Δnp63 As A Suppressor of Migration, Invasion, and Metastasis
… Nonetheless, understanding the basics of tumor development and progression are the key to focused on studying the role of ΔNp63 in cancer, a p53 family member known to be involved in epithelial development, microRNA biogenesis, and stem cell maintenance. Using the strength of <em>in vivo …
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Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development
… and proliferation, especially during cancer development, are balanced by the surrounding environment. Complex polysaccharides called glycosaminoglycans (GAGs) are part of this environment and they are known to modulate tumor development. One of these GAGs, dermatan/chondroitin sulfate …
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Elucidating the Role of BMI1 in Lung and Colon Tumor Maintenance and Progression
… It is postulated that within heterogeneous tumor tissues, there exists a subpopulation of cells, termed cancer stem cells (CSCs), with the ability to initiate and support tumor growth, promote metastatic spreading, and drive relapse following chemoradiotherapy. Given the high tumorigenic …
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Atp-Citrate Lyase Links Cyclin E to Cellular Metabolism In Breast Cancer
… or overexpressed in approximately one-third of tumors from patients with invasive breast cancer and is a powerful independent predictor for survival in women with stage I-III breast cancer. Full-length cyclin E (EL) is post-translationally cleaved into two low-molecular-weight isoforms, LMW-E …
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