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Showing 1 to 20 of 33 for “"Tularensis"”.
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Site-Directed Mutagenesis in Francisella Tularensis by Allelic
Francisella tularensis is a Gram-negative, facultative intracellular coccobacillus and the etiologic agent of tularemia for a wide variety of vertebrate and invertebrate animal species. Several species and subspecies of Francisella are currently recognized. However, the majority of infections are …
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The Potential Role for CapB in Pathogenesis of Francisella tularensis
Francisella tularensis was a facultative intracellular pathogen and a gram-negative coccobacillus which has been categorized by the CDC as a potential class A select agent due to its highly infectious properties and high mortality rates. Francisella tularensis was also responsible for the zoonotic …
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Interactions of Francisella Tularensis With Components of the Host Fibrinolytic System
<p><em>Francisella tularensis</em> (FT) is a Gram-negative coccobacillus and causative agent of a life-threatening disease commonly referred to as tularemia. Due to the highly infectious nature of the organism, its previous development as a biowarfare agent and its potential use in acts of …
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Identification and characterization of a novel capsule-like complex surface antigen of Francisella tularensis
Francisella tularensis is a highly virulent zoonotic pathogen that is the causative agent of tularemia in humans. Two subspecies of F. tularensis are the most virulent in humans: tularensis (type A) and holarctica (type B), with less than 10 organisms via aerosol of a type A strain having the …
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Genomic Instability and Gene Dosage Obscures Clues to Virulence Mechanisms of F. tularensis species
The pathogen Francisella tularensis subsp. tularensis has been classified as a Center for Disease Control (CDC) select agent. However, little is still known of what makes the bacteria cause dis-ease, especially the highly virulent type A1 strains. The work in this dissertation focused on type A1 …
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Identification and characterization of the acid phosphatase from Francisella tularensis and its potential role in pathogenesis
… study show that the intracellular pathogen, F. tularensis (Ft) produces a respiratory burst-inhibiting acid phosphatase. The acid phosphatase appears to be identical in three strains tested. Like many microbial acid phosphatases, FtACP has been localized to the periplasmic space of the organism. …
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Surface Polysaccharides of Francisella tularensis: Further Characterization, Role in Virulence, and Application to Novel Vaccine Strategies
Francisella tularensis is a Gram-negative, zoonotic bacterium that causes tularemia in animals and humans. The two subspecies tularensis (Type A) and holarctica (Type B) are considered Tier I Select Agents due to the bioweapon potential of these subspecies. Type A strains, considered the more …
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Mechanisms Involved in Enhanced Protection Against Gram Negative Bacterium Francisella tularensis Utilizing an FcR Targeted Vaccine Platform
<p>Francisella tularensis is a gram-negative intracellular bacterium and the etiologic factor of a potentially fatal disease tularemia. Due to its high infectivity the Centers for Disease Control and Prevention has designated F. tularensis as a Category A biological agent. Nevertheless, the …
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Infection Rates of Amblyomma Americanum and Dermacentor Variablis by Francisella Tularensis and Borrelia Lonestari in Southwest Missouri
<p>Francisella tularensis and Borrelia lonestari are the bacteria that cause tularemia and erythema migrans-like rash, respectively. F. tularensis is capable of being transmitted to humans through the bite of an infected Amblyomma americanum tick or Dermacentor variabilis tick, while the primary …
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Characterisation and therapeutic modulation of toll-like receptor signalling in response to the intracellular pathogen F. tularensis
… obligate intracellular bacterial pathogen, F. tularensis, successfully invades and replicates within immune and epithelial cells. However, despite significant research the exact mechanisms used by this pathogen to successfully evade the host immune response remain elusive. To establish the …
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Use of Cholera Toxin B as a Vaccine Adjuvant Activates Antigen Presenting Cells and Stimulates Production of Pro-Inflammatory Cytokines
<p><em>Francisella tularensis</em> is an intracellular pathogen that has been classified as a category “A” bioterrorism agent by the Centers For Disease Control. To date, there is no approved vaccine to provide protection against this pathogen. Previous <em>in vivo </em>studies with mice<em> …
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Prevalence and environmental risk factors for ten zoonoses in two cree communities of James Bay (Canada
… sp. (23%), Coxiella burnetii, Francisella tularensis (17%, titer > 1/20), Toxoplasma gondii (5%), the Sin Nombre virus (0%), two of the virus of the California serogroup (10%) (Snowshoe hare and Jamestown Canyon viruses) and of than less 5% for Echinococcus granulosus, Toxocara canis and …
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Development of diagnostic immunoassays for tularemia and leptospirosis
The zoonotic bacteria Francisella tularensis and Leptospira species are the causative agents for tularemia and leptospirosis respectively. Both of these diseases have significant deficits in the diagnostic tools available for efficient early diagnosis, which can result in delayed treatment of these …
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Zoonosis bacterianas transmitidas por animales de compañía diagnosticadas en el Hospital Universitario Central de Asturias y papel de los perros como reservorio de genes de resistencia a los antimicrobianos
… multocida, Afipia felis y Francisella tularensis, todas ellas asociadas a la convivencia con estos animales. Asimismo, se analizó el rol de los perros sanos como posibles portadores de enterobacterias resistentes a los antimicrobianos.
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Mapping pathogen distributions and population connectivity of a sentinel Arctic species, the polar bear (Ursus maritimus) across a changing North American Arctic
… Erysipelothrix rhusiopathiae, Francisella tularensis, and Mycobacterium tuberculosis complex (MTBC), and two parasites T. gondii and Trichinella spp.) relevant to wildlife and human health; and (iii) Quantify the spatial distributions of focal pathogens in polar bear tissues and observe …
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High Resolution Mass Spectrometry (HRMS) Based Investigation of Small Molecule, Bioactive Secondary Metabolites as Probes in the Examination of Bacterial Resistance and Virulence
… techniques. Chapter 2 introduces the bacterium F tularensis and M ulcerans and details the MS based investigation of their secreted virulence factors. Chapter 3 introduces a human pathogen of particular concern, M tuberculosis, and contains a detailed reporting on the MS based investigation of …
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Identification and Characterization of the Hfq protein and small RNAs in Francisella novicida
<italic>Francisella tularensis</italic> is the causative agent of the disease tularemia and a potential bioterrorism agent. Few regulators have been identified in this organism and little is known about its genetic regulatory networks. In this dissertation project, culture-based and molecular …
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Development of an Optical Fiber Biosensor with Nanoscale Self-Assembled Affinity Layer
… strains, such as Brucella and Francisella tularensis have also been studied using a similar biosensor platform with DNA probes and antibodies, respectively, and the outcomes are also promising. The Brucella DNA biosensor is able to reflect the existence of 3 Brucella strains at 100 cfu/ml …
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Ecology of the Coyote (Canis latrans) at Wind Cave National Park
… to canine distemper virus (CDV), Fransicella tularensis, and Yersinia pestis, (2) to determine home range and core area size, (3) to index population abundance and determine coyote density, (4) to determine resource selection, (5) to determine food habits, and (6) to document den sites of …
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