Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Tudor domain"”.
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A Study of The Snd1/Prmt5 Axis In Liver Cancer By Genetic Mouse Models
… to facilitate signaling. Staphylococcal nuclease Tudor domain containing 1 (SND1) is an effector that specifically binds SDMA via its single C-terminal Tudor domain. Both SND1 and PRMT5 have been implicated in hepatocellular carcinoma (HCC). SND1 has been confirmed as a driver of HCC using …
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Essential Protein Factors in pre-mRNA splicing : A Structural Study by Nuclear Magnetic Resonance Spectroscopy
… Chapter 1 presents the solution structure of the Tudor domain of the human Survival of Motor Neuron (SMN) protein and its molecular interaction with the spliceosomal Sm proteins. Sm proteins are common components of small nuclear ribonucleoprotein particles (snRNPs), which are assembled by a …
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HISTONE-DEPENDENT AND HISTONE-INDEPENDENT PATHWAYS FOR RAD9 CHROMATIN RECRUITMENT AND CHECKPOINT ACTIVATION
… interacts with methylated H3-K79 thanks to its Tudor domain. Impairment of this recruitment-pathway prevents Rad9 and Rad53 phosphorylation in G1-arrested cells and abolishes the G1-S arrest following DNA damage. Surprisingly in M-arrested cells, deletion of Dot1 or mutation of the Rad9 Tudor …
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Discovery of Novel Ubiquitin- and Methylation-Dependent Interactions Using Protein Domain Microarrays
… by interacting with "reader" proteins. Protein domain microarray is a high throughput platform to identify novel readers for PTMs. In this dissertation, I applied two protein domain microarrays identifying novel readers for histone H2Aub1 and H2Bub1, and H3TM K4me3. Ubiquitinations of histone …
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Transposable Elements and the Evolution of Virus Resistance in Drosophila melanogaster
… rely on the functioning of the key protein domains Ven_tra encodes: an MYND Zinc finger and a Tudor domain. We work on further characterizing this allele by narrowing down the pathways it interacts and find it does not require a functional siRNA pathway to cause resistance, and fail to show …
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… we show that MED12 interacts with the Tudor domain-containing effector molecule, TDRD3, in a CARM1-dependent fashion. These findings reveal an arginine methylation regulatory node on the Mediator complex that may facilitate the communication between DNA-bound transcription factors and …
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Context Dependent Regulation of Dicer Function During Oocyte-to-Embryo Transition
… including the revelation that the Dicer helicase domain has an exclusive regulatory effect on developmental endo-siRNAs. Despite this revelation, the mechanisms regulating Dicer helicase domain activity and subsequent endo-siRNA biogenesis are enigmatic due to the responsibility of Dicer’s …