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Showing 1 to 11 of 11 for “"Tubulins."”.
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Prosthecobacter BtubAB form bacterial mini microtubules
… that spans through all kingdoms of life, with αβ-tubulins being the eukaryotic representatives and FtsZ being the best studied prokaryotic homologue. It is believed that all tubulin/FtsZ-related proteins have evolved from a common ancestor, however, members from this superfamily have diverged in …
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The Substrate and Regulator of Acetyltransferase San
… demonstrated that tubulin is a San substrate. Tubulins are the building blocks of microtubules, which display dynamic instability. By regulating the rate of microtubule assembly and disassembly, cells organize the microtubule cytoskeleton to accommodate their specific functions. …
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Biochemical and immunocytochemical analysis of three novel microtubule-associated proteins in Drosophila melanogaster and the rat brain
… conserved proteins, the $\alpha$- and $\beta$-tubulins. Many of the functions associated with microtubules are thought to be due to the proteins that associate with them and are collectively termed microtubule-associated proteins or MAPs. Microtubule proteins (MTP), isolated from Drosophila …
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Investigating a novel Asgard archaeon and its tubulin-like proteins
… unexplored in the Asgard Archaea. Eukaryotic tubulins are members of the Tubulin Superfamily (TSF), alongside their prokaryotic counterparts, such as FtsZ, and are critical components of the cytoskeleton. In vitro characterisation of the eukaryotic tubulin homologue from Odinarchaeota (called …
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INSIGHTS INTO POLYMERISATION OF FTSZ AND OTHER CYTOMOTIVE FILAMENTS
… The protein FtsZ, a homologue of eukaryotic tubulins, forms cytomotive filaments that are used in almost all bacteria and many archaea to organise cell division. Here I show using X-ray crystallography and electron cryomicroscopy (cryoEM) that FtsZ switches conformation when it polymerises …
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Structure-Based Mechano-Chemical Modeling of Microtubule Nucleation
… are analogous to the structural transitions of tubulins within the MT. These changes maintain a sheetlike structure during the nascent MT formation, which resists catastrophes and thereby promotes successful nucleation. This unified framework resolves many longstanding experimental puzzles and …
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Quantitative analysis of signaling networks in proneural glioblastoma
… as increased phosphorylation of Eno₁, ELMO₂, and tubulins. Invasion was further characterized in a lung cancer model where we identified signaling specific to different ligands that result in similar levels of invasion. We have demonstrated that unbiased, quantitative phosphotyrosine proteomics …
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Mechanics and Kinetics of Microtubules in Their Environment
… structural change induced by hydrolysis of GTP-tubulins on the average MT growth time before shrinkage, as a function of tubulin concentration, using a mean-first-passage-time (MFPT) method. The results are comparable with experiment in the low-medium concentration regime, making it a potential …
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Untersuchungen zur Rolle des Phosphoproteins Stathmin in Listeria monocytogenes-infizierten Säugerzellen und Molekulare Charakterisierung der listeriellen Zweikomponetensysteme
… Dieses Protein bindet an Untereinheiten des Tubulins und destabilisiert dadurch Mikrotubuli (MT). Es wird durch Phosphorylierung von vier spezifischen Serinresten in seiner MT-destabilisierenden Aktivität reguliert. Da Stathmin als Antwort auf externe Signale zelluläre Funktionen, z. B. …
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Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.
Cancer remains a deadly affliction for millions across the United States, and the number of new cases is only expected to rise in the years to come. In the field of anticancer research, vascular disrupting agents (VDAs) that preferentially target the tumor vasculature show great promise. The …
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Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
Vascular disruption is an innovative method for treating cancer. By selectively altering the endothelial cells of tumor vasculature, the tumor can be destroyed by oxygen deprivation and starvation. The combretastatin (CA) family of small molecules has shown great effectiveness as vascular …