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Showing 1 to 1 of 1 for “"Tubulin-binding molecules."”.
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Design and synthesis of indole-based analogues of OXi8006 as inhibitors of tubulin polymerization and their incorporation as payloads in drug-linker constructs.
… University, exhibited potent inhibition of tubulin polymerization and strong cytotoxicity against human various cancer cell lines. In previous studies, OXi8007, the phosphate prodrug of OXi8006, demonstrated vascular disrupting activity within 2 hours of administration by targeting tumor …