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Showing 1 to 1 of 1 for “"Tubulin Modulators"”.
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The Use of C. Elegans to Identify Mutations That Confer Drug Resistance, Using Hemiasterlin as an Example
Hemiasterlin is a natural product isolated from the several species of marine sponges. Hemiasterlin inhibits microtubule polymerization resulting in cell cycle arrest and apoptosis. Cells over-expressing efflux pumps associated with multidrug resistance are not resistant to the toxic effects of …