"Tubulin Inhibitors" · 7 results

Discovery of Novel Tubulin Inhibitors and Selective Survivin Inhibitors for Advanced Melanoma and Total Synthesis of Bioactive 20S-hydroxyvitamin D3

Wang, Qinghui2018

… to develop new generations of bioavailable tubulin inhibitors targeting the colchicine binding site and selective small-molecule survivin inhibitors for treating advanced melanoma. Extensive structure-activity relationship (SAR) studies of lead molecules ABI-231 and UC-112 have been …

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VERU-111 as an Oral Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer and Evaluation of Novel Tubulin Inhibitors for Cancer Therapy

Deng, Shanshan2022

Triple negative breast cancer (TNBC) has aggressive clinical features strongly associated with poorer overall prognosis and higher mortality rates relative to other molecular subtypes. FDA-approved drugs, such as paclitaxel, are effective in treating TNBC. Yet, treatment failure is commonly …

tenn-hsc Repository record for VERU-111 as an Oral Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer and Evaluation of Novel Tubulin Inhibitors for Cancer Therapy (opens in a new tab)

Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase

Devambatla, Ravi Kumar Vyas2018

… in the areas of multitargeted single agents and tubulin inhibitors in cancer chemotherapy and selective Toxoplasma gondii TS inhibitors for the treatment of toxoplasmosis. Tubulin inhibitors are important antitumor agents that disrupt microtubule dynamics. Thymidylate synthase (TS) …

duquesne Repository record for Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase (opens in a new tab)

The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions

Namjoshi, Ojas2019

Abstract withheld

duquesne Repository record for The Synthesis of pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as receptor tyrosine kinase inhibitors or tubulin inhibitors or inhibitors of dihydrofolate reductases and the development of inhibitors or inhibitors of dihydrofolate reductases and the development of metal-catalyzed cross-coupling reactions (opens in a new tab)

Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors

Arnst, Kinsle E.2019

Tubulin inhibitors are widely used as chemotherapeutic agents, and their successis attributed to their ability to target microtubule dynamics and disrupt critical cellular functions including cell signaling, motility, intracellular trafficking, and mitosis. Interference with microtubule dynamics …

tenn-hsc Repository record for Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors (opens in a new tab)

The Development of Assays for Detecting Proximal Phosphorylation and Covalent Modification of Proteins

Cabral, Aaron David2021

… warhead platform for novel covalent inhibitors. Through nucleophilic aromatic substitution methodology, selectively derivatized polyfluorinated benzene rings were synthesized to construct an electrophilic warhead library that could be electronically and sterically tuned for specific …

toronto-retro Repository record for The Development of Assays for Detecting Proximal Phosphorylation and Covalent Modification of Proteins (opens in a new tab)

Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents

Albadari, Najah Ghazi2025

… important cancer targets: survivin, MDM2, and tubulin. Survivin, a member of the inhibitor of apoptosis proteins (IAPs) family, serves as both an apoptosis suppressor and a pivotal player in cell division. Its significance as a cancer drug target arises from its heightened expression in various …

tenn-hsc Repository record for Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents (opens in a new tab)

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