Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Tuberculosis--Treatment"”.
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Development of antibiotic microneedle delivery systems for tuberculosis treatment
Current therapy of tuberculosis (TB) has several limitations, such as risk of liver injury and intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal administration could be used to improve antibiotic delivery for treatment of Mycobacterium tuberculosis infection. …
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Population pharmacokinetic and pharmacodynamic modelling to improve tuberculosis treatment
Tuberculosis continues to claim millions of lives each year despite enormous efforts to control the epidemic over the past century. It remains the leading cause of death worldwide from a curable infectious disease. Tuberculosis is a significant cause of maternal mortality and morbidity, but little …
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The role of gender in patient-provider trust for tuberculosis treatment
Background: In South Africa, tuberculosis (TB) is the leading cause of death, and Cape Town is among the three cities in the country with the highest TB burden. Despite implementation of Directly Observed Treatment Short-Course (DOTS), and improvements in the organisation and delivery of TB care, …
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Investigating mobile graphic-based reminders to support compliance of tuberculosis treatment
… supporting patients, such as those who have tuberculosis, for treatment adherence. This utilization will enable these patients to directly communicate their needs and requirements or receive health information such as reminder messages from healthcare facilities. However, the current mobile …
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Advancing tuberculosis treatment through pharmacometric modeling of drug exposure and biomarkers
Tuberculosis remains the leading cause of death from a single infectious agent globally, posing a significant threat to public health. This highlights the need for improved treatment strategies to enhance outcomes and limit the emergence of resistance. Optimizing therapy requires more reliable …
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Intervention strategies to improve tuberculosis treatment adherence in Limpopo Province, South Africa
Even though tuberculosis is curable, it remains a major cause of ill-health among millions of people. Globally tuberculosis is the second leading cause of death from an infectious disease after the Human immunodeficiency virus. The major unresolved challenge in the management of tuberculosis is …
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Population/ Nonlinear mixed-effects modelling of pharmacokinetics and pharmacodynamics of tuberculosis treatment
… doses for drug-susceptible and -resistant tuberculosis. Concentration-time data from the RAFA study were used to characterise the pharmacokinetics of the four drugs of the fixed dose combination (FDC) therapy including desacetyl-rifampicin, and acetyl-isoniazid. Binary recursive techniques …
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Gastric-resident drug delivery system for prolonged gram-level dosing of Tuberculosis treatment
… one of the biggest challenges facing effective treatment of disease around the world. In developing and developed countries, approximately 50-70% of patients fail to correctly follow the drug regimen prescribed by their health care providers. Gastric resident systems have the potential to …
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Characterization and quantification of urinary metabolic biomarkers for early response to anti-tuberculosis treatment
Development of new anti-tuberculosis (TB) therapies remains a major priority to combat this infectious disease and to prevent continued transmission of the causative agent Mycobacterium tuberculosis (Mtb). However, newly developed therapies require large, lengthy clinical trials to determine the …
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Nonlinear mixed-effects modelling of drug-drug interactions between antiretroviral therapy and tuberculosis treatment
… Among people with HIV (PWH), co-infection with tuberculosis (TB) is a leading cause of death. However, the concurrent treatment of HIV and TB often results in drug-drug interactions (DDIs), mediated especially by rifampicin, a key component of the TB regimen and potent enzyme and transporter …
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Outcome of Tuberculosis treatment in sputum positive patients after eight months of anti-tuberculosis therapy
… of the study was to find out the outcome of tuberculosis treatment in Sputum Positive Patients after eight months anti-tuberculosis treatment. Observation and literature review has shown that there has been an increase in the number of tuberculosis patients since 1980 .A large proportion of …
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Outcome of Tuberculosis treatment in sputum positive patients after eight months of anti-tuberculosis therapy
… of the study was to find out the outcome of tuberculosis treatment in Sputum Positive Patients after eight months anti-tuberculosis treatment. Observation and literature review has shown that there has been an increase in the number of tuberculosis patients since 1980 .A large proportion of …
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Factors associated with non-adherence to anti-tuberculosis treatment in the Vhembe District, South Africa
Background: Failure to adhere TB patients to tuberculosis therapy is a major challenge that challenges the efforts to eradicate tuberculosis. While ground-breaking approaches have been introduced to reduce the number of people who are unable to finish their prescribed TB drugs, there is still quite …
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PATIENT PREFERENCES, STRUCTURE, AND HIV ARE ASSOCIATED WITH ADHERENCE TO TUBERCULOSIS TREATMENT IN URBAN UGANDA
Background: Tuberculosis programs have focused only on microbiologic and clinical outcomes of cure and mortality, yet HIV and patient preferences including patient satisfaction and health-related quality of life (HRQoL) may be important determinants of low adherence to prescribed tuberculosis …
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Knowledge, attitudes and practices of patients diagnosed with Tuberculosis related to Tuberculosis treatment adherence in Keetmanshoop district, Namibia
Ensuring that patients in chronic care and treatment such as tuberculosis adhere to medications has implications for their quality of life, health care costs and society at large. The purpose of this study was to assess and describe the knowledge, attitudes and practices of patients diagnosed with …
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Factors associated with outcomes of patients placed on tuberculosis treatment in the western geographic service area of Cape Town
… In the Western Cape Province of South Africa, tuberculosis (TB) is a major health problem and in 2012 accounted for 7.40% of premature deaths. The Province has also experienced an increase in TB incidence in the past 20 years. Objectives The aims of the study were to describe the distribution …
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Factors influencing non-adeherence to tuberculosis treatment in TB/HIV co-infected adults at the University Teaching Hospital,Lusaka,Zambia
… aim of this study was to explore barriers to TB treatment adherence and determine the prevalence of non-adherence in the Zambian capital of Lusaka. The factors under study were socio-economic and demographic, service-related and disease and treatment related factors. A cross-sectional study was …
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Development of Amorphous Ternary Solid Dispersions of a Novel Anti-Tubercular Indole-2-Carboxamide Derivative with Curcumin/Clofazimine for Tuberculosis Treatment
This research presents novel amorphous ternary (drug-drug-hydrophilic polymer) solid dispersions to simultaneously enhance the aqueous solubility of incorporated poorly soluble drugs. A highly potent novel anti-tubercular drug (i.e., Indole-2-carboxamide derivative (North 2)) was combined with an …
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Tuberculosis treatment delay in adults and household transmission to children: a community-based study in a setting with high burden of tuberculosis and HIV
Background: Tuberculosis (TB) control depends on interrupting transmission through rapid diagnosis and treatment initiation of infectious TB cases. With increasing delay in the diagnosis and treatment of pulmonary TB, disease is likely to progress, leading to progressive lung cavitation and …
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An examination of the implementation of the World Health Organisation's anti-tuberculosis treatment, the Directly Observed Treatment Short Course (DOTS), in poor South African communities
… examines the implementation of the anti-tuberculosis treatment, the Directly Observed Treatment Short Course, of the World Health Organisation (WHO) in poor South African communities. Research for this dissertation was carried out over a two-year period in one poor community, a …
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