Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Tuberculosis, HIV"”.
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Tuberculosis, HIV, food insecurity, and poverty in rural Zambia : an ethnographic account of the Southern province
… terms of food security and accessing both TB and HIV treatment.
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Factors influencing non-adeherence to tuberculosis treatment in TB/HIV co-infected adults at the University Teaching Hospital,Lusaka,Zambia
Zambia is a high TB/HIV prevalence country. The aim of this study was to explore barriers to TB treatment adherence and determine the prevalence of non-adherence in the Zambian capital of Lusaka. The factors under study were socio-economic and demographic, service-related and disease and treatment …
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Challenges that offenders face upon release that contribute to recidivism in the Department of Correctional Services: a case study of the West Coast Medium ' A' Correctional Centre in the Western Cape
… leads to numerous communicable diseases such as tuberculosis, HIV/AIDS and other sexuality transmitted infections. Offenders participate in various rehabilitation programmes during their incarceration. However, the challenge is to sustain these rehabilitation efforts after their discharge from …
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Design of bicycle ambulances for Zambia
… from various ailments including cholera, tuberculosis, HIV/AIDS, blindness, broken bones, anemia, and pneumonia.
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Diagnosis, treatment and determinants of mortality in patients hospitalized with HIV-associated tuberculosis
Background: HIV-associated tuberculosis (HIV-TB) comprises 9% of global tuberculosis cases but contributes a disproportionate 17% of tuberculosis deaths. Tuberculosis is the leading cause of death, hospitalization and in-hospital death in HIV-positive patients world-wide with case fatality rates in …
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The transciptomic landscape of HIV-TB
… 1 of this thesis I provide a broad overview of HIVTB with an emphasis on systems approaches followed by an overview of a systems-level study aiming at addressing hypotheses relating to transcriptional differences in active tuberculosis and HIV-1 infection, measured in blood and the site of …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis (TB), is the leading cause of death in people living with Human Immunodeficiency Virus (HIV). Treatment of co-infected persons is challenging due to the aggressive course of both individual diseases, and often is further …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis (TB), is the leading cause of death in people living with Human Immunodeficiency Virus (HIV). Treatment of co-infected persons is challenging due to the aggressive course of both individual diseases, and often is further …
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Effect of diabetes and HIV on radiographic manifestations of pulmonary tuberculosis
… prevalence in South Africa is increasing, while HIV prevalence remains high. Diabetes, along with HIV, has been found to be a significant risk factor for the development of tuberculosis. Early detection and treatment of tuberculosis is essential to prevent unwarranted morbidity and mortality. …
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Exploring new methodologies to identify disease-associated variants in African populations through the integration of patient genotype data and clinical phenotypes derived from routine health data: A case study for Type 2 Diabetes Mellitus in patients in the Western Cape Province, South Africa
… diseases (diabetes) and infectious diseases (Tuberculosis, HIV and COVID-19). 459 participants consented to providing a DNA sample and access to their routine health data and were included in the feasibility study. A total of 343 DNA samples and 1782023 genotyped variants passed quality …
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Pathology and mechanisms of increased M.tb growth and dissemination during co-infection with HIV-1
… is latently infected with Mycobacterium tuberculosis (M.tb). M.tb and HIV have a deadly synergy that occurs during co-infection. Individuals with HIV infection are at significantly increased risk for acquiring or reactivating latent TB infections. Further, there is increased TB pathology …
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PATIENT PREFERENCES, STRUCTURE, AND HIV ARE ASSOCIATED WITH ADHERENCE TO TUBERCULOSIS TREATMENT IN URBAN UGANDA
Background: Tuberculosis programs have focused only on microbiologic and clinical outcomes of cure and mortality, yet HIV and patient preferences including patient satisfaction and health-related quality of life (HRQoL) may be important determinants of low adherence to prescribed tuberculosis …
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Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
Mycobacterium tuberculosis (M.tb) is the most common co-infection and leading cause of death among HIV+ individuals. Several animal models are available to study TB infection although many do not reproduce disease pathology similar to humans. The human host tropism of HIV limits its study in animal …
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Characterising the immunometabolic profile of HIV/TB co-infection
… between the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) during co-infection of a host is well established. While this synergy is driven by immunological deterioration, the metabolic mechanisms that contribute to the …
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Patients’ perspectives on the provision of tuberculosis and HIV integrated services in Sisonke district, KwaZulu Natal
Viewing the provision of TB-HIV integrated services from the perspectives of TB/HIV clients can help to identify ways to enhance the provision of these services. The aim of this study was to assess the provision of TB/HIV services including PMTCT from clients perspectives in order to make …
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The immunological role of cell wall components from diverse Mycobacterium tuberculosis clinical isolates in regulating HIV-1 replication in human macrophages
Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium tuberculosis (Mtb) coinfection remains a major global health threat. Both pathogens synergistically drive pathogenesis of the other. The risk of developing active tuberculosis (TB) is increased in people living with HIV-1, even in those …
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Newer and novel sputum versus non-sputum-based tools for the diagnosis of active tuberculosis in different patient sub-populations
Background Pulmonary tuberculosis (PTB) has a spectrum of presentation ranging from sub clinical/minimally symptomatic disease on one end, usually in community-based patients, to overt symptomatic TB with hospitalisation on the severe end of the spectrum. This spectrum of sub-clinical and clinical …