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Showing 1 to 4 of 4 for “"Tsa1"”.
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The Thiol Specific Antioxidant (TSA1) Gene is Required for Survival in Macrophages and Oxidative Stress Resistance in Histoplasma Capsulatum
… <p>The thiol specific antioxidant gene, <em>Tsa1,</em>is strongly upregulated in the yeast (pathogenic) morphotype. This data led to the hypothesis that this gene plays a role in protecting <em>Hc</em>from host mediated oxidative attack. To characterize <em>Tsa1 </em>function, a knockdown …
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On chaperone co-operation in temporal and spatial protein quality control
… additional activity from the peroxiredoxin Tsa1. Tsa1 is needed to recruit chaperones to misfolded proteins during oxidative stress. Interestingly, this is also true for stress caused by ageing, and increasing the level of Tsa1 can prolong the lifespan of yeast. The Stress Seventy subfamily …
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Thiol-Based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
… and recruits chaperones such as Hsp104 and Tsa1. These chaperones assist in clearing existing aggregates and preventing further damage. Above all, protein aggregation as a result of exposure to thiol-specific stress extends to human cells, thus establishing a conserved mechanism and model …
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The effects of elevated mitochondrial hydrogen peroxide in S. cerevisiae : a physiological role for cytochrome c peroxidase
… strain deficient in thioredoxin peroxidase (x tsa1 ), and its possible involvement in redox signaling, is also discussed.