Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Ts65Dn"”.
-
Skeletal Muscle Function, Morphology, and Biochemistry in Ts65Dn Mice: A Model of Down Syndrome
… characterization of skeletal muscle from the Ts65Dn mouse, a model of Down syndrome. The experiments revealed that Ts65Dn muscle over-expresses SOD1 protein but this did not lead to oxidative stress. Ts65Dn soleus muscles displayed normal force generation in the unfatigued state, but exhibited …
-
Developmental Differences and Altered Gene Expression in the Ts65Dn Mouse Model of Down Syndrome
… of the conserved phenotypes between species. The Ts65Dn Down syndrome mouse model has triplicated homologues for approximately half the genes on human chromosome 21 and exhibits many phenotypes that parallel those found in individuals with DS. Specifically, newborn and adult Ts65Dn mice display …
-
DYRK1A-Related Trabecular Defects in Male Ts65Dn Mice Emerge During a Critical Developmental Window
… skeletal development in young male Ts65Dn mice to test the hypothesis that skeletal defects in male Ts65Dn mice are developmental in nature.Femurs from young mice ranging from postnatal day 12- to 42-days of age (P12-42) were measured and analyzed by microcomputed tomography (μCT). …
-
Quantifying Dyrk1a During Perinatal Development in the Hippocampus, Cerebral Cortex and Cerebellum of the Ts65Dn
… of age, sex, and brain region in trisomic Ts65Dn mice compared to euploid counterparts and 2) establish that the spatiotemporal pattern of developmental DYRK1A in the brain is not influenced solely by gene copy number, and that reduction of Dyrk1a in euploid and trisomic mice does not …
-
Effect of Epigallocatechin-3-gallate on a pattern separation task and hippocampal neurogenesis in a mouse model of Down syndrome
… of phenotypes including intellectual disability. Ts65Dn mice, the most extensively studied DS model, have three copies of ~50% of the genes on Hsa21 and display many phenotypes associated with DS, including cognitive deficits. DYRK1A is found in three copies in humans with Trisomy 21 and in Ts65Dn …
-
Identifying phenotypic change across time in mouse models of Down syndrome
… in people with Down syndrome. The Ts(1716)65Dn (Ts65Dn) mouse is one of the most commonly used models as it recapitulates many of the phenotypes seen in individuals with Down syndrome, including neuroanatomical changes and impaired learning and memory. Although Ts65Dn exhibits a number of traits …
-
Molecular Basis and Modification of a Neural Crest Deficit in a Down Syndrome Mouse Model
… that underlie many DS anomalies. The Ts65Dn mouse model, trisomic for half of the Hsa 21 orthologs replicates many DS phenotypes including craniofacial alterations such as a small, dysmorphic mandible, midface, and maxilla. Other mouse models, such as the Ts1Rhr which contains a …
-
Characterizing Femoral Structure of the Ts66Yah Mouse Model of Down Syndrome
… genome structures between humans and mice. Ts65Dn mice have been a popular model of DS as they contain ~50% of Hsa21 orthologous genes on a freely segregating minichromosome, but there is speculation that the phenotypes are exaggerated by non-Hsa21 orthologous trisomic genes also present. To …
-
The Impact of Gamma Stimulation on Neurological Phenotypes of Alzheimer's Dementia and Down Syndrome
… investigation into the use of GENUS in adult Ts65Dn mice, a mouse model of Down syndrome (DS). Chronic exposure resulted in significant genetic and immunohistochemical changes related to synapse organization and adult neurogenesis within the hippocampus, as well as an improvement in spatial …
-
Metabolomics of Mammalian and Cellular Models of Aging
… to an accelerated aging phenotype. In the Ts65Dn mouse model of DS, a premature aging phenotype is also observed along with other common comorbidities associated with human DS. Here, we report changes in the both global and targeted metabolomics (the study of small molecules) in the brains …
-
Alterations of High-Energy Brain Metabolites Across Multiple Neurodegenerative Disorders
… a trisomic mouse model for Down syndrome (Ts65Dn), and following administration of Tat to primary mouse cortical cultures as a model for HIV-1 dementia. My experiments also examined the extent to which protection is provided by creatine supplementation and the ketogenic diet in models of …
-
The functional role of the retromer complex in the pathogenesis of Alzheimer's disease in Down syndrome
… complex at 2, 5, 9 and 12 months of age in the Ts65dn mouse model of DS. While we observed accelerated aging related cognitive and pathological changes in DS mice, we did not observe any protein levels changes in the retromer complex. However, because these mice do develop endosomal dysfunction …