Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Trypanosomiasis, African"”.
-
The Role of S-Adenosylmethionine Decarboxylase on Regulation of Polyamine and Trypanothione Metabolism in Trypanosoma Brucei
… brucei is the causative agent of Human African Trypanosomiasis (HAT), a fatal and neglected disease affecting Sub-Saharan Africa. Current therapeutics are limited for several reasons, underscoring the need for new and improved drugs. The polyamine/trypanothione pathway is essential for …
-
Uncovering the Role of 5'-Nucleotidases in Pyrimidine Metabolism in Trypanosoma brucei
… parasite Trypanosoma brucei causes the disease African trypanosomiasis in humans and nagana in cattle. Fifty-five million people in subtropical countries are at risk for contracting T. brucei through the tsetse fly vector, and infection is typically fatal if untreated. While recent interventions …
-
Identification and Characterization of Drug Targets in the Pyrimidine and Purine Pathways of Trypanosoma brucei
… parasite Trypanosoma brucei causes Human African Trypanosomiasis (HAT), which is fatal if untreated. Current therapies result in severe side effects and require complex treatment regimens. In an effort to spur the development of effective, safe, and simple to administer drugs, my work …
-
Prevalence of human African trypanosomiasis and its associated risk factors in Itezhi-tezhi district of Zambia.
Human African Trypanosomiasis (HAT) is a debilitating zoonotic disease caused by trypanosomes which are transmitted by tsetse flies of the genus Glossina. This study aimed to determine the prevalence and risk factors of HAT in Itezhi-Tezhi (ITT) District of Zambia through active surveillance. Human …
-
The role of erythropoietin in the pathophysiology of anemia associated with trypanosomiasis
African trypanosomiasis is one of the most important hemoprotozoan diseases affecting both humans and livestock in sub-Saharan Africa. A blunted erythropoietin (Epo) response has been proposed as one possible mechanism that contributes to the nonresponsive anemia in trypanosome-infected cattle. The …
-
Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
African trypanosomiasis is a disease caused by the Kinetoplastida parasites Trypanosoma brucei rhodesiense and T. b. gambiense. The distribution of the disease is split geographically with T. b. rhodesiense found in eastern sub-Saharan Africa and T. b. gambiense in the west of the continent. …