Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Trypanosomes"”.
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Expression and behaviour of GPI-anchored surface proteins in trypanosomes
… process present in the ancestor of African trypanosomes or has it evolved subsequent to the VSG coat? The ability of two trypanosome species, Trypanosoma theileri and Trypanosoma carassii to remove surface bound biotin-streptavidin and biotin-IgG complexes from their surfaces was tested. T. …
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Characterization of a unique sulfoxide synthase found in pathogenic trypanosomes
Includes abstract. Includes bibliographical references.
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Origins and composition of the cullin-RING E3 ligases in trypanosomes
Ubiquitylation is a post-translation modification essential for protein homeostasis that controls the fate of the targeted proteins by inducing their degradation, controlling enzymatic activity or changing cellular localisation following the covalent attachment of ubiquitin to a lysine residue of …
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VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control
African trypanosomes are major human and animal pathogens in sub-Saharan Africa that cycle between a mammal and tsetse fly vector. In the mammalian host, these parasites exist exclusively extracellularly. To evade the adaptive immune system, trypanosomes undergo antigenic variation of the variant …
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Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes
… lysates. Furthermore, the in vitro efficacy in trypanosomes could be reverted by target over-expression. Further validation of its activity “on target” was given by its ability to modulate the cell toxicity caused by TbGSK3 short over-expression. The genetic validation of TbGSK3 short by …
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The Role of S-Adenosylmethionine Synthetase in Killing Effects of DFMO in African Trypanosomes
T. brucei parasites cause a fatal disease that affects hundreds of thousands of people in sub-Saharan Africa. Since current treatment options show either poor efficacy or have safety concerns, it is necessary to identify new targets in the parasite for the development of better medication against …
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Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes
… are available for detection and strain typing in trypanosomes. These tools include nested ITS-PCR, which is based on size variation of the ITS genes and MGE-PCR, which is based on variations in position of mobile genetic elements (MGEs). Although commonly used, these tools have not been fully …
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Understanding Primate Immunity to African Trypanosomes Through the Characterization of Trypanosome Lytic Factor Formation and Function
<p>African trypanosomes cause an annual loss of over 1 billion USD due to their economic and agricultural burden in Sub-Saharan Africa. These parasites are unicellular, extracellular parasites, that infect humans, cattle, and other livestock. Humans and some non-human primates are protected against …
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An evolutionary genomics approach towards analysis of genes implicated in transmission of trypanosomes between tsetse fly and mammalian host
… for interrupting the transmission cycle of trypanosomes, specifically using any of the three players,the human host, the tsetse fly vector and/or the parasite. The human genome has been deciphered and the genomes of several trypanosome species have been sequenced. Sequencing of additional …
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Molecular characterization of trypanosomes commonly found in cattle, wild animals and tsetse flies in Kwazulu-Natal, South Africa, 2005-2007
… (PCR and RFLP) to detect and characterize trypanosomes in cattle, wild animals and tsetse flies in KwaZulu-Natal, thus contributing to improved understanding of the genetic diversity of trypanosome species infecting cattle at the game/livestock interface in the KwaZulu-Natal Province of …
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
… series have potent in vitro activity against trypanosomes that is better than or equal to the current chemotherapeutic compound diminazene, and some Series 1 compounds are on a par with pentamidine and melarsoprol. No major cross-resistance was displayed by the TbAT1 knockout strain to either …
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Concurrent Infections of TRYPANOSOMA EQUIPERDUM and TRICHINELLA SPIRALIS in Mice
… intestinal tissue invasion. Mice infected with trypanosomes after the 7th day of the <em>Trichinella</em> infection have survival time increases to a significant point and a steady leveling off to Day 21. It is suggested that the antibodies produced against the <em>Trichinella</em> worms slow …
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Folate transport and drug resistance in the African Trypanosome
… and resistance of antifolate drugs in African trypanosomes with a specific focus on transport mechanisms. A media deficient in folate and thymidine was established which enabled the assessment of their modulation on antifolate in vitro potencies and also screen a small set of antifolate …
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Effect of Temperature upon Reproduction and Cyclic Development of Culture Forms of Trypanosoma Avium
… in general, particularly those pathogenic trypanosomes which infect mammals, relatively little research has been directed toward those forms which infect birds.
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Studies on protozoan parasites of small mammals
… observationof the development of mammalian trypanosomes in mites. In these mitesan isosporan-type coccidian (with developmental stages of sporogonyand gametogony) was also found and described. The sporulation ofoocysts was completed inside the mite's body and was typicallyisosporan with 2 …
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Concurrent Infections of SCHISTOSOMA MANSONI and TRYPANOSOMA EQUIPERDUM in Mice
… <em>T. equiperdum</em>, it was found that trypanosomes removed from the donor rat should be kept at 25 C and all counts, dilutions of the organisms, and injection should be completed within 1 hour after removal from the donor host. Survival time of mice is increased as the interval between …
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Epidemiological role of indigenous dogs in the transmission of animal and human African trypanosomiasis in Zambia: a case study of dogs from Mambwe District
… in dogs. However, recent studies have detected trypanosomes in Zambian dogs. As a follow-up, the current research was designed to investigate what communities know about tsetse flies and AT and the role that dogs might play as trypanosome hosts. Data from the knowledge, attitudes, and practices …
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Histone Modifications in Trypanosoma Brucei
… subtelomeric regions of several chromosomes. How trypanosomes maintain monoallelic expression of VSG is a major question in trypanosome biology. Several theories have been proposed, including the presence of an Expression Site Body (a dedicated 'transcription factory'), regulation of RNA …
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