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Showing 1 to 20 of 68 for “"Trypanosoma cruzi"”.
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Genómica y transcriptómica comparativa de Trypanosoma Cruzi
El parásito Trypanosoma cruzi es conocido como el agente etiológico de la enfermedad de Chagas, según reportes de la Organización Mundial de la Salud (OMS) se encuentra dentro de las 17 enfermedades tropicales desatendidas y es la tercera infección parasitaria más común en todo el mundo después de …
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Biological studies of GPI-anchoring in Trypanosoma cruzi
Trypanosoma cruzi, a protozoan parasite transmitted to humans via triatomine\r\ninsects, causes chronic chagasic cardiomyopathy (CCM) in ~30% of infected individuals.\r\nThis dissertation sought to characterize T. cruzi’s pathogenic mechanisms by cellular,\r\nbiochemical, and molecular genetics …
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Osmoregulation in Trypanosoma Cruzi: The Role of the Acidocalcisome
Electron microscopic observations revealed a contractile vacuole coupled to acidocalcisomes in all three life cycle stages of the parasite. An aquaporin homologue localized to the acidocalcisomes and contractile vacuole. In epimastigotes expressing a GFP-aquaporin fusion protein, acidocalcisomes …
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The Effects of Lead Acetate on Host Susceptibility to Trypanosoma Cruzi
Trypanosoma cruzi. a protozoan parasite, causes American trypanosomiasis or Chagas' disease. The infective stage of this parasite resides in the hindgut of the reduviid bug (family Reduviidae), which is both host and vector, and is transmitted to the mammalian host through fecal material released …
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<em>Trypanosoma Cruzi</em> in Wild Raccoons and Opossums from Kentucky
… may be infected with the etiologic agent, <i>Trypanosoma cruzi</i>. The parasite has been isolated from a variety of wild mammals, particularly in the southeastern region of the U.S.A. The goal of our study was to determine if the sylvatic cycle of <i>T. cruzi</i> infection occurs in Kentucky, …
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T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection
The human pathogen Trypanosoma cruzi is an intracellular parasite and the etiological agent of Chagas disease. Protective immune responses to T. cruzi are highly dependent on T helper 1 and CD8+ T cells which produce interferon-gamma. A deficiency in these responses has severe consequences on the …
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Estudo citoquímico de enzimas mitocondriais de Trypanosoma cruzi em culturas de tecido
… locate the activity of rnitochondrial enzymes in Trypanosoma cruzi in tissue cultures a cytochemical study at light and electron rnicroscopic levels was performed using chick embryo heart rnuscle cultures infected by the Y strain of the parasite. Tetrazolium salts were used as hidrogen aceptors of …
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Understanding and modulating macrophage metabolism for improving inflammatory functions against Trypanosoma cruzi infection
… in macrophages for improving the clearance of Trypanosoma cruzi infection. T. cruzi is the etiologic agent of Chagas disease, which affects over 8 million people and current therapy has limited efficacy. Macrophages are one of the first sentinels to T. cruzi infection yet are susceptible to …
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Endogenous Gene Tagging of pfr2 and pfr5 in Trypanosoma cruzi Using CRISPR/Cas9
The flagellum of <em>Trypanosoma cruzi </em>contains the paraflagellar rod (PFR) an extra-axonemal scaffolding. The PFR consists of a lattice of cytoskeletal filaments that lies alongside the (9 + 2) microtubular axoneme, beginning at the flagellar pocket and extending to the flagellar tip. The PFR …
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Perfil epidemiológico da infecção por Trypanosoma cruzi em regiões de vulnerabilidade do Brasil
Introduction: The spread of T. cruzi infection is directly related to its mode of transmission, and the primary control actions are those that prevent or hinder the contact of the parasite with humans and domestic animals. Therefore, it is essential to understand the socio-epidemiological …
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Síntese de Derivados Aril-Semicarbazônicos como Protótipos Moleculares Contra o Trypanosoma cruzi (Antichagas)
… anticonvulsivante e principalmente anti T. cruzi. Neste trabalho, derivados aril-semicarbazônicos foram sintetizados por meio da reação de condensação entre diversos aril-aldeídos substituídos e a semicarbazida hidroclorada, os quais tiveram suas estruturas confirmadas por meio de …
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Trypanosoma Cruzi Phosphoinositide -Specific Phospholipase C (tcpi-Plc) and Its Role in Differentiation
A newly discovered Trypanosoma cruzi phosphoinositide phospholipase C (TcPI-PLC) is lipid modified in its N-terminus, and located in the plasma membrane of amastigotes. The N-terminal 20 amino acids of TcPI-PLC contain primary structural information sufficient to target the heterologous Aequorea …
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Evaluation of the Success of Adoptive Versus Passive Transfer of Immunity Against Trypanosoma Cruzi
… increased resistance to the protozoal parasite Trypanosoma cruzi (the causative agent of Chagas' disease) in highly susceptible C3H mice when maintained at an environmental temperature of 36°C. This increased resistance is manifested as delay in onset of parasitemia, decreased parasitemia, …
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Congenital Chagas Murine Model Development and Nanovaccine Efficacy Against Maternal-fetal Trypanosoma cruzi Pathogenesis
Maternal infection with Trypanosoma cruzi (Tc) parasite can lead to the vertical transmission from mother to fetus known as congenital Chagas’ disease (cCD). The objective was to develop a murine model of cCD to test the efficacy of a DNA nanovaccine developed by our laboratory. In this …
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High Diversity of Trypanosoma Cruzi Discrete Typing Units Circulating in Triatoma in Western Mexico
… disease is caused by the protozoan parasite <em>Trypanosoma cruzi</em>, which is transmitted to domestic and sylvatic mammals via the feces of hematophagous hemiptera of the subfamily Triatominae (Reduviidae). <em>Trypanosoma cruzi</em> is found only in the Americas and displays remarkable …
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Regulation of Intracellular pH and Plasma Membrane Potential in Trypanosoma Cruzi and Trypanosoma Brucei
… in all stages of the pathogenic protozoans, T. cruzi and T. brucei utilizing the pH sensitive fluorescent dye BCECF and the potentiometric fluorescent dye bisoxonol. pH i in T. cruzi was found to be regulated primarily by a H+-ATPase with support from a Cl- conductive channel in all stages and …
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Expresión y purificación del factor acelerador del decaimiento de la convertasa recombinante de Trypanosoma cruzi
Trypanosoma cruzi, protozoo perteneciente a la familia Trypanosomatidae, es el agente causal de la enfermedad de Chagas. El principal mecanismo de transmisión de esta enfermedad es vectorial, por medio de insectos hemípteros hematófagos de la familia Reduviidae. Los tripomastigotes, formas …
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A Phosphoinositide-Specific Phospholipase C of Trypanosoma Cruzi: Unique Characteristics of a Delta-Type Homologue
… (TcPI-PLC  ) of the protozoan parasite Trypanosoma cruzi was cloned, sequenced, expressed in E. coli, and the protein product (TcPI-PLC) was shown to have enzymatic characteristics similar to those of mammalian delta-type PI-PLCs. The TcPI-PLC gene is expressed at high levels in the …
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Soropositividade de anticorpos anti-Toxoplasma gondii e anti-Trypanosoma cruzi em populações ribeirinhas do recôncavo baiano
… to Toxoplasma gondii and total antibodies to Trypanosoma cruzi. For toxoplasmosis, in Cabaceiras do Paraguaçu, 74 individuals were screened, with a mean age of 33.84 (± 20.92). The majority were female, over 31 years of age, with a family income below one minimum wage, self-identified as …
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Síntese e avaliação de tiossemicarbazonas e tiazolinonas como inibidores da protease cruzaína do Trypanosoma cruzi (TCC)
… a uma possível inibição da enzima cruzaína do Trypanosoma cruzi (TCC). A cruzaína é uma enzima responsável pela replicação intracelular do T. cruzi e, devido a esta função, é um alvo explorado para o desenvolvimento de novas drogas potencialmente antichagásicas. Neste trabalho, objetivou-se a …
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